Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Laising Yen"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 12, p e1009985 (2021)
Oncogenic fusion genes as the result of chromosomal rearrangements are important for understanding genome instability in cancer cells and developing useful cancer therapies. To date, the mechanisms that create such oncogenic fusion genes are poorly u
Externí odkaz:
https://doaj.org/article/249bcf7c94464c3194365dec4d0a16ed
Autor:
Sachin Kumar Gupta, Laising Yen
Publikováno v:
Cells, Vol 11, Iss 6, p 1002 (2022)
One common genetic alteration in cancer is gene fusion resulting from chromosomal translocations. The mechanisms that create such oncogenic fusion genes are not well understood. Previously, we provided the direct evidence that expression of a designe
Externí odkaz:
https://doaj.org/article/0f0bc41832ae4d31bb13bd02aaf16d64
Autor:
Nithila A. Joseph, Shiow-Her Chiou, Zoe Lung, Cheng-Lin Yang, Tze-Yi Lin, Hui-Wen Chang, H. Sunny Sun, Sachin Kumar Gupta, Laising Yen, Shulhn-Der Wang, Kuan-Chih Chow
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-14 (2018)
Abstract Background Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation and hepatocyte growth f
Externí odkaz:
https://doaj.org/article/ce307a8360e44cf2a922aea74b6d012c
Autor:
Kalpana Kannan, Cristian Coarfa, Kimal Rajapakshe, Shannon M Hawkins, Martin M Matzuk, Aleksandar Milosavljevic, Laising Yen
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004216 (2014)
Ovarian cancer is the fifth leading cause of cancer death in women. Almost 70% of ovarian cancer deaths are due to the high-grade serous subtype, which is typically detected only after it has metastasized. Characterization of high-grade serous cancer
Externí odkaz:
https://doaj.org/article/957ab4ae8d464651a58cacfe92212c4d
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8529 (2010)
Deep sequencing of transcriptome (RNA-seq) provides unprecedented opportunity to interrogate plausible mRNA splicing patterns by mapping RNA-seq reads to exon junctions (thereafter junction reads). In most previous studies, exon junctions were detect
Externí odkaz:
https://doaj.org/article/1022f2917e894576a4c77b829766b9e1
Autor:
Shaw-Jenq Tsai, H. Sunny Sun, Laising Yen, Ning Chang, Sachin Kumar Gupta, Ya-Chi Lin, Kuei-Yang Hsiao
Figure S1. Alignments between full-length read to exon(s). Figure S2. CircRNAs validation in CRC. Figure S3. Sanger sequencing results for the backsplice junction. Figure S4. Hypoxia tunes the levels of linear and circular CCDC66 transcripts. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2ba3fafc197561822f89c90fbf9dd7
https://doi.org/10.1158/0008-5472.22416557.v1
https://doi.org/10.1158/0008-5472.22416557.v1
Autor:
Shaw-Jenq Tsai, H. Sunny Sun, Laising Yen, Ning Chang, Sachin Kumar Gupta, Ya-Chi Lin, Kuei-Yang Hsiao
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbfbe70266d4743ae003d665e1289d8
https://doi.org/10.1158/0008-5472.22416563
https://doi.org/10.1158/0008-5472.22416563
Autor:
Shaw-Jenq Tsai, H. Sunny Sun, Laising Yen, Ning Chang, Sachin Kumar Gupta, Ya-Chi Lin, Kuei-Yang Hsiao
Circular RNA (circRNA) is a class of noncoding RNA whose functions remain mostly unknown. Recent studies indicate circRNA may be involved in disease pathogenesis, but direct evidence is scarce. Here, we characterize the functional role of a novel cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e9908f6efdc94225350235e4fa42fe
https://doi.org/10.1158/0008-5472.c.6509585.v1
https://doi.org/10.1158/0008-5472.c.6509585.v1
Autor:
Shaw-Jenq Tsai, H. Sunny Sun, Laising Yen, Ning Chang, Sachin Kumar Gupta, Ya-Chi Lin, Kuei-Yang Hsiao
The list of miRNAs targeting exons 8 to 10 of CCDC66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed59f1d032d43af6d26aeb6e7183a8f6
https://doi.org/10.1158/0008-5472.22416551
https://doi.org/10.1158/0008-5472.22416551
The ability to control the expression of a therapeutic gene or a transgene in mammalian cells is crucial for safe and efficacious gene and cell therapy, as well as for elucidating the function of a specific gene product. Yet current mammalian gene re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee81aea9d1a13d46581042974ead7649
https://doi.org/10.1101/2023.01.27.525935
https://doi.org/10.1101/2023.01.27.525935