Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lais P. Ghiraldeli"'
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, David D. Hurd, Dianna S. Howard, Dmitriy Berenzon, Leslie R. Ellis, Wei Zhang, Guangxu Jin, Jeff W. Chou, Lance D. Miller, Lais P. Ghiraldeli, Scott Isom, Kristin M. Pladna, Rebecca G. Anderson, Timothy S. Pardee
Figure S1. Dose escalation schema. Figure S2. Acetyl-CoA synthetase is expressed in OCI-AML3 and MFL2 cells. Figure S3 Acetate and methyl-succinate rescue of CPI-613 cytotoxicity. Figure S4. Treatment schema. Figure S5. Efficacy of HiDAC, mitoxantron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa013db81e0b8aa200a02dd48f34207
https://doi.org/10.1158/1078-0432.22463990.v1
https://doi.org/10.1158/1078-0432.22463990.v1
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, David D. Hurd, Dianna S. Howard, Dmitriy Berenzon, Leslie R. Ellis, Wei Zhang, Guangxu Jin, Jeff W. Chou, Lance D. Miller, Lais P. Ghiraldeli, Scott Isom, Kristin M. Pladna, Rebecca G. Anderson, Timothy S. Pardee
Supplemental methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b667b6990793075a03413465a31aff
https://doi.org/10.1158/1078-0432.22463987
https://doi.org/10.1158/1078-0432.22463987
Autor:
Bayard L. Powell, Susan Lyerly, Sarah Dralle, Megan Manuel, David D. Hurd, Dianna S. Howard, Dmitriy Berenzon, Leslie R. Ellis, Wei Zhang, Guangxu Jin, Jeff W. Chou, Lance D. Miller, Lais P. Ghiraldeli, Scott Isom, Kristin M. Pladna, Rebecca G. Anderson, Timothy S. Pardee
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate dehydrogenase (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism in chemotherapy re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa6abca3e8f8542b007234c73ae901b
https://doi.org/10.1158/1078-0432.c.6525593.v1
https://doi.org/10.1158/1078-0432.c.6525593.v1
Autor:
Komaraiah Palle, Ralph B. D'Agostino, Jonathan R. Brody, Lais P. Ghiraldeli, David L. Caudell, Thomas L. Smith, Sezgin Kiren, Alex Haber, William H. Gmeiner, Anthony Dominijanni, Chinnadurai Mani, Boris Pasche, Zhiyong Deng
Publikováno v:
Mol Cancer Ther
Chemotherapy regimens that include 5-fluorouracil (5-FU) are central to colorectal cancer treatment; however, risk/benefit concerns limit 5-FU’s use, necessitating development of improved fluoropyrimidine (FP) drugs. In our study, we evaluated a se
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1870:96-102
Mitochondria have long been controversial organelles in cancer. Early discoveries in cancer metabolism placed much emphasis on cytosolic contributions. Initial debate focused on if mitochondria had a role in cancer formation and progression at all. M
Autor:
Leslie R. Ellis, Susan Lyerly, Dmitriy Berenzon, Megan Manuel, Wei Zhang, Dianna S. Howard, Timothy S. Pardee, Sarah Dralle, Bayard L. Powell, Rebecca G. Anderson, Jeff W. Chou, Scott Isom, Lance D. Miller, Kristin M. Pladna, Lais P. Ghiraldeli, Guangxu Jin, David D. Hurd
Publikováno v:
Clinical Cancer Research. 24:2060-2073
Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and α-ketogluterate dehydrogenase (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism in chemotherapy re
Publikováno v:
Blood. 132:2633-2633
Introduction: Acute myeloid leukemia is an aggressive malignancy characterized by relapse and resistance to therapy. When treated with standard chemotherapy 60-80% of patients will achieve a remission however most will suffer a relapsed and once rela