Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Laird Bloom"'
Autor:
Adam R. Root, Gurkan Guntas, Madan Katragadda, James R. Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C. King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fang Jin, Nicole Piche-Nicholas, Sinead E. Keating, Fernando Narciandi, Rosemary Lawrence-Henderson, Maya Arai, Wayne R. Stochaj, Kristine Svenson, Lidia Mosyak, Khetemcnee Lam, Christopher Francis, Kimberly Marquette, Liliana Wroblewska, H. Lily Zhu, Alfredo Darmanin Sheehan, Edward R. LaVallie, Aaron M. D’Antona, Alison Betts, Lindsay King, Edward Rosfjord, Orla Cunningham, Laura Lin, Puja Sapra, Lioudmila Tchistiakova, Divya Mathur, Laird Bloom
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Externí odkaz:
https://doaj.org/article/25a52ae4f12b462d933f760c7786789d
Autor:
Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Gareth Young, Kim Marquette, Sadhana Jain, Kerry Kelleher, Ting Chen, Qingcong Lin, Laird Bloom, Laura Lin, William Finlay, Rie Suzuki, Orla Cunningham
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The role of brain-derived neurotrophic factor (BDNF) signaling in chronic pain has been well documented. Given the important central role of BDNF in long term plasticity and memory, we sought to engineer a high affinity, peripherally-restricted monoc
Externí odkaz:
https://doaj.org/article/ae8632cb22914515949ff21d2cb4fad8
Autor:
Adam R. Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Jocelyn Sanford, Macy Jin, Cliona O’Sullivan, Emma Cummins, Matthew Lambert, Alfredo D. Sheehan, Weijun Ma, Scott Gatto, Kelvin Kerns, Khetemenee Lam, Aaron M. D’Antona, Lily Zhu, William A. Brady, Susan Benard, Amy King, Tao He, Lisa Racie, Maya Arai, Dianah Barrett, Wayne Stochaj, Edward R. LaVallie, James R. Apgar, Kristine Svenson, Lidia Mosyak, Yinhua Yang, Gurunadh R. Chichili, Liqin Liu, Hua Li, Steve Burke, Syd Johnson, Ralph Alderson, William J. J. Finlay, Laura Lin, Stéphane Olland, William Somers, Ezio Bonvini, Hans-Peter Gerber, Chad May, Paul A. Moore, Lioudmila Tchistiakova, Laird Bloom
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec
Externí odkaz:
https://doaj.org/article/8c0c6589f19a4745bedbcd5e1b1c60a5
Autor:
Michael E Hurwitz, Pamela J Vanderzalm, Laird Bloom, Julia Goldman, Gian Garriga, H. Robert Horvitz
Publikováno v:
PLoS Biology, Vol 7, Iss 6 (2009)
Externí odkaz:
https://doaj.org/article/e3c8f80c93e647889485a137a2d96ae4
Autor:
Michael E Hurwitz, Pamela J Vanderzalm, Laird Bloom, Julia Goldman, Gian Garriga, H Robert Horvitz
Publikováno v:
PLoS Biology, Vol 7, Iss 4, p e99 (2009)
The engulfment of apoptotic cells is required for normal metazoan development and tissue remodeling. In Caenorhabditis elegans, two parallel and partially redundant conserved pathways act in cell-corpse engulfment. One pathway includes the adaptor pr
Externí odkaz:
https://doaj.org/article/7255e61658d94f66951fa3aa6d4c08df
Autor:
Puja Sapra, Anhco Nguyen, Lioudmila Tchistiakova, Lindsay E. King, Laird Bloom, Edward Rosfjord, Bernard S. Buetow, Diane R. Fernandez, Edward R. LaVallie, Jatin Narula, Johnny Yao, Erik Upeslacis, Rosemary F. Lawrence-Henderson, Kerry Kelleher, Cris Kamperschroer, Chad Stevens, Cynthia M. Rohde, Jonathan Golas, Magali Guffroy, Justin Lucas, Jessica C. Kearney, Wei Fang, Xingzhi Tan, Stephanie Bisulco, Bozena Bugaj-Gaweda, Adam R. Root, Divya Mathur
Mouse body weights of LS1034 tumor bearing mice treated with GUCY2C(M)-CD3 using adoptive T cell transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015f56dd0dc4694194f85b374d685a02
https://doi.org/10.1158/1078-0432.22478477.v1
https://doi.org/10.1158/1078-0432.22478477.v1
Autor:
Puja Sapra, Anhco Nguyen, Lioudmila Tchistiakova, Lindsay E. King, Laird Bloom, Edward Rosfjord, Bernard S. Buetow, Diane R. Fernandez, Edward R. LaVallie, Jatin Narula, Johnny Yao, Erik Upeslacis, Rosemary F. Lawrence-Henderson, Kerry Kelleher, Cris Kamperschroer, Chad Stevens, Cynthia M. Rohde, Jonathan Golas, Magali Guffroy, Justin Lucas, Jessica C. Kearney, Wei Fang, Xingzhi Tan, Stephanie Bisulco, Bozena Bugaj-Gaweda, Adam R. Root, Divya Mathur
Table S2. Surface Plasmon Resonance binding affinities of anti-GUCY2C/anti-CD3ε bispecifics to human, mouse and cynomolgus GUCY2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5922498d4ccfe501fb5b6d828164e255
https://doi.org/10.1158/1078-0432.22478444.v1
https://doi.org/10.1158/1078-0432.22478444.v1
Autor:
Puja Sapra, Anhco Nguyen, Lioudmila Tchistiakova, Lindsay E. King, Laird Bloom, Edward Rosfjord, Bernard S. Buetow, Diane R. Fernandez, Edward R. LaVallie, Jatin Narula, Johnny Yao, Erik Upeslacis, Rosemary F. Lawrence-Henderson, Kerry Kelleher, Cris Kamperschroer, Chad Stevens, Cynthia M. Rohde, Jonathan Golas, Magali Guffroy, Justin Lucas, Jessica C. Kearney, Wei Fang, Xingzhi Tan, Stephanie Bisulco, Bozena Bugaj-Gaweda, Adam R. Root, Divya Mathur
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405a946b7b8e1765ac457b018cb76fed
https://doi.org/10.1158/1078-0432.22478450
https://doi.org/10.1158/1078-0432.22478450
Autor:
Orla Cunningham, Eric Sousa, Susan Benard, Yongjing Guo, C.M. Francis, Puja Sapra, Laura Lin, Lindsay King, Fang Jin, Weijun Ma, Aaron M. D’Antona, Nicole Piche-Nicholas, Sinead E. Keating, Sara Hanscom, Gurkan Guntas, Wayne Stochaj, Khetemcnee Lam, Claire Hendershot, Liliana Wroblewska, H. Lily Zhu, Kimberly Ann Marquette, Kristine Svenson, Divya Mathur, Fernando Narciandi, Yan Liu, Weili Duan, Edward R. Lavallie, Alison Betts, Rosemary Lawrence-Henderson, Chang Chew Shun, Adam Root, Maya Arai, Madan Katragadda, Amy King, Amy Tam, Jatin Narula, Jason Wade, Kerry Kelleher, Lioudmila Tchistiakova, Lidia Mosyak, Alfredo Darmanin Sheehan, Han Yang, Yan Zhang, James R. Apgar, Edward Rosfjord, Laird Bloom, Caryl L. Meade, Matthew McKenna
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c6dd5658cfd24d66b5b31b6d32bf8c
https://pubmed.ncbi.nlm.nih.gov/33459147
https://pubmed.ncbi.nlm.nih.gov/33459147
Autor:
Laura Lin, Orla Cunningham, Laird Bloom, Jason Wade, Sheridan McMurray, Edwina Stack, Sadhana Jain, Gordon McMurray, Kerry Kelleher, Gareth T. Young, Melissa Clark, William J.J. Finlay, Rie Suzuki, Qingcong Lin, Kim Marquette, Ting Chen
Publikováno v:
mAbs
The role of brain-derived neurotrophic factor (BDNF) signaling in chronic pain has been well documented. Given the important central role of BDNF in long term plasticity and memory, we sought to engineer a high affinity, peripherally-restricted monoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590f492dddee75b70b25f41a67102d4b
https://doi.org/10.1080/19420862.2020.1755000
https://doi.org/10.1080/19420862.2020.1755000