Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laiq Chaudry"'
Autor:
John Barrett, Catherine Nye, Don O. Somers, Roberto Solari, John D. Harling, Sebastien Andre Campos, Rachel Grimley, Rebecca H. Graves, Christina M. Bessant, Angela M. Deakin, Laura Hanns, William J. Kerr, Oxana Polyakova, Nick Barton, Laiq Chaudry
Publikováno v:
Journal of Biological Chemistry. 288:28195-28206
IL-2-inducible tyrosine kinase (Itk) plays a key role in antigen receptor signaling in T cells and is considered an important target for anti-inflammatory drug discovery. In order to generate inhibitors with the necessary potency and selectivity, a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae4f29a0279ef07ef494bc4aa68fb8c
https://doi.org/10.1074/jbc.m113.474114
https://doi.org/10.1074/jbc.m113.474114
Autor:
Stefan Senger, Máire A. Convery, Robert J. Young, Stephanie Irvine, Iain M. McLay, Robert I. West, David J. Belton, Savvas Kleanthous, Carl Adams, John R. Toomey, Anne M. Exall, Anthony J. Pateman, Theresa J. Roethke, Caroline M. Whittaker, Laiq Chaudry, David E. Davies, Angela Patikis, Cynthia L. Burns-Kurtis, Nigel S. Watson, Gary J. Stelman, David W. Brown, John D. Harling, Wendy R. Irving, Chuen Chan, Ping Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1588-1592
The discovery and evaluation of potent and long-acting oral sulfonamidopyrrolidin-2-one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are described. Unexpected selectivity issues versus tissue plasminogen activator in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff85f937ce4e89e1a2bcffaac9ddca4
https://doi.org/10.1016/j.bmcl.2011.01.129
https://doi.org/10.1016/j.bmcl.2011.01.129
Autor:
Savvas Kleanthous, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Matthew Campbell, Laiq Chaudry, Chuen Chan, Marie-Olive Clarte, Máire A. Convery, John D. Harling, Eric Hortense, Wendy R. Irving, Stephanie Irvine, Anthony J. Pateman, Angela N. Patikis, Ivan L. Pinto, Derek R. Pollard, Theresa J. Roethka, Stefan Senger, Gita P. Shah, Gary J. Stelman, John R. Toomey, Nigel S. Watson, Robert I. West, Caroline Whittaker, Ping Zhou, Robert J. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:618-622
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa inhibitors, incorporating neutral and basic monoaryl P4 groups, ultimately producing potent inhibitors with effective levels of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c703cdb093d395dc4c312cc73a2b70
https://doi.org/10.1016/j.bmcl.2009.11.077
https://doi.org/10.1016/j.bmcl.2009.11.077
Autor:
Anthony J. Pateman, John R. Toomey, Paul F. Koster, Augustin Amour, Saul Needle, Laiq Chaudry, Melanie A Abboud, Champa Patel, Angela Patikis, Cynthia L. Burns-Kurtis, Robert J. Young, Richard E. Valocik, David Brown, Ping Zhou, Chuen Chan, Nigel S. Watson
Publikováno v:
Journal of Cardiovascular Pharmacology. 52:66-71
Background: Factor Xa (FXa) has been a target of considerable interest for drug development efforts aimed at suppressing thrombosis. In this report, a new orally active, small molecule, active-site directed FXa inhibitor, GW813893, has been profiled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4ecf88e87e341213f5fef72bbcb248
https://doi.org/10.1097/fjc.0b013e31817e9b9e
https://doi.org/10.1097/fjc.0b013e31817e9b9e
Autor:
Sumitra Ramachandran, Angela A. Dunne, Neil Derek Miller, Laiq Chaudry, Vincent Jaquet, Craig Allan, Aleksandra Filippova, Jean Lim, Ceri H. Davies, Agnes B. Ong, May Thu Ma, Shabina Nasir, Woei Shin Chen, Nicole Y. Ye, Edward R. Browne, Kiew Ching K Lee, Shihua Liao, Douglas G. Johns, Angela Bridges, Yasuji Matsuoka, Chiu Cheong Aw, A. Richard Rutter, Adeline L.W. Chueng, Dizheng Li, Deborah W. Chen, Sri Mulyanidewi, Sarah Duncan, Tamara Seredenina, Gary Pettman, Kazufumi Hirano, Pamela P. Oon
Publikováno v:
Antioxidants & redox signaling, Vol. 23, No 5 (2015) pp. 358-374
Aims: The NADPH oxidase (NOX) family of enzymes catalyzes the formation of reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of physiological processes but also contribute to oxidative stress in certain disease states.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ea3e136424a97ddab898f120e2665
https://europepmc.org/articles/PMC4545375/
https://europepmc.org/articles/PMC4545375/
Autor:
Máire A. Convery, Stephanie Irvine, Graham Foster, Mike Blows, Robert J. Young, Steve Jackson, Stefan Senger, Angela Patikis, Eric Hortense, Cynthia L. Burns-Kurtis, John R. Toomey, Carl Adams, Savvas Kleanthous, Gary J. Stelman, David W. Brown, John D. Harling, Nigel S. Watson, Ping Zhou, Robert I. West, Wendy R. Irving, Anne M. Exall, Theresa J. Roethka, David E. Davies, Anthony J. Pateman, Chuen Chan, Laiq Chaudry, Caroline M. Whittaker
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
The rational design, syntheses and evaluation of potent sulfonamidopyrrolidin-2-one-based factor Xa inhibitors incorporating aminoindane and phenylpyrrolidine P4 motifs are described. These series delivered highly potent anticoagulant compounds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a38372eac43a80c90c25beb16d8fc57
https://pubmed.ncbi.nlm.nih.gov/21349710
https://pubmed.ncbi.nlm.nih.gov/21349710
Autor:
Robert J. Young, Alan D. Borthwick, Nigel S. Watson, Weston Helen Elisabeth, Chun-wa Chung, J. Nicole Hamblin, Chuen Chan, Anthony J. Pateman, Savvas Kleanthous, Laiq Chaudry, Shah Gita Punjabhai, David W. Brown, Matthew Campbell, Champa Patel, Máire A. Convery, Stefan Senger, Lisa Johnstone, Angela Patikis, Cynthia L. Burns-Kurtis, Henry Anderson Kelly, Caroline Whitworth, Ping Zhou, John R. Toomey
Publikováno v:
Journal of medicinal chemistry. 50(7)
Factor Xa inhibitory activities for a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides with different P1 groups are described. These data provide insight into binding interactions within the S1 primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f306dec874ed8280047fe0634d5b309a
https://pubmed.ncbi.nlm.nih.gov/17338508
https://pubmed.ncbi.nlm.nih.gov/17338508
Autor:
Vipulkumar Kantibhai Patel, Máire A. Convery, J. Nicole Hamblin, Andrew M. Mason, Andrew R. Leach, N. Paul King, Shah Gita Punjabhai, Stefan Senger, Laiq Chaudry, Caroline Whitworth, Rebecca Fenwick, Robert J. Young, Matthew Campbell, Cynthia L. Kurtis, Claudine Haslam, Henry Anderson Kelly, Champa Patel, Weston Helen Elisabeth, Charlotte Jane Mitchell, David W. Brown, Gary R. Manchee, Nigel S. Watson, Chuen Chan
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(14)
A series of novel, non-basic 3-(6-chloronaphth-2-ylsulfonyl)aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an alanylamide P4 group, was designed and synthesised. Within this series, the N-2-(morpholin-4-yl)-2-oxoethyl derivativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e4aa8609923e3b93ebe2c35a44f9bf
https://pubmed.ncbi.nlm.nih.gov/16697194
https://pubmed.ncbi.nlm.nih.gov/16697194
Autor:
Chuen Chan, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Matthew Campbell, Laiq Chaudry, Chun-wa Chung, Máire A. Convery, J. Nicole Hamblin, Lisa Johnstone, Henry A. Kelly, Savvas Kleanthous, Angela Patikis, Champa Patel, Anthony J. Pateman, Stefan Senger, Gita P. Shah, John R. Toomey, Nigel S. Watson, Helen E. Weston
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 7, p1546-1557, 12p
Publikováno v:
Biochemical Society Transactions. 17:752-753
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c23c7e7ae06e75fa5c2ac5325c242ac
https://doi.org/10.1042/bst0170752
https://doi.org/10.1042/bst0170752