Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lainne E. Seitz"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:1685-1695
6-Oxo and 6-thio analogs of purine were prepared based on the initial activity screening of a small, diverse purine library against Mycobacterium tuberculosis (Mtb). Certain 6-oxo and 6-thio-substituted purine analogs described herein showed moderate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25dac3b571f1383cecaf4c6838fc04e7
https://doi.org/10.1016/j.bmc.2013.01.054
https://doi.org/10.1016/j.bmc.2013.01.054
Autor:
Vibha Pathak, Ashish K. Pathak, Robert C. Reynolds, Gurdyal S. Besra, Sudagar S. Gurcha, Lainne E. Seitz, James M. Riordan
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:5629-5650
Glycosyltransferases (GTs) play a crucial role in mycobacterial cell wall biosynthesis and are necessary for the survival of mycobacteria. Hence, these enzymes are potential new drug targets for the treatment of tuberculosis (TB), especially multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d2513d560c4220a90fe380173eab5c
https://doi.org/10.1016/j.bmc.2007.04.012
https://doi.org/10.1016/j.bmc.2007.04.012
Publikováno v:
Medicinal Chemistry. 2:505-510
The present study extends our previous work regarding new antifolates for Mycobacterium avium (MAC) dihydrofolate reductase (DHFR). The objectives of this study were to synthesize and test new derivatives in the general class of 2,4-diamino-5-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e64a0905af99224b6c9b38138238314
https://doi.org/10.2174/157340606778250225
https://doi.org/10.2174/157340606778250225
Autor:
Peg Davis, Edward J. Bilsky, Frank Porreca, Jeffrey L. Bartlett, Richard B. Rothman, Subramaniam Ananthan, Christina M. Dersch, Lainne E. Seitz, Naveen K. Khare, Surendra K. Saini
Publikováno v:
Journal of Medicinal Chemistry. 47:1400-1412
A series of pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone (7a-k) were synthesized and evaluated for binding affinity at the opioid delta, micro, and kappa receptors in brain membranes using radioligand binding assays and for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad388e7da9902f7ce6276c376de8a88a
https://doi.org/10.1021/jm030311v
https://doi.org/10.1021/jm030311v
Publikováno v:
Journal of Medicinal Chemistry. 47:273-276
Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb). Certain 6-thio-substituted purine analogues described herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46775a808e01726eb9159fa1903ff63f
https://doi.org/10.1021/jm030389b
https://doi.org/10.1021/jm030389b
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:111-114
Compounds originally designed as putative tubulin inhibitors were tested as antitubercular agents for inhibition of the Mycobacterium tuberculosis analogue of tubulin, FtsZ. Initial screening of 200 2-alkoxycarbonylpyridines found several that inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e53e7d64dede3c4b845919747e9139
https://doi.org/10.1093/jac/dkf075
https://doi.org/10.1093/jac/dkf075
Autor:
Robert C. Reynolds, Kamal N. Tiwari, M. S. Akhtar, Ashish K. Pathak, Vibha Pathak, Lainne E. Seitz
Publikováno v:
Tetrahedron Letters. 42:7755-7757
A mild, efficient and inexpensive detritylation method is reported that uses trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f21a77a57c95e0dab8285aa41092239c
https://doi.org/10.1016/s0040-4039(01)01645-8
https://doi.org/10.1016/s0040-4039(01)01645-8
Autor:
Kamal N. Tiwari, Lainne E. Seitz, M. S. Akhtar, Ashish K. Pathak, Vibha Pathak, Robert C. Reynolds
Publikováno v:
ChemInform. 33
A mild, efficient and inexpensive detritylation method is reported that uses trifluoroacetic acid on a silica gel column to obtain pure, detritylated compounds in one-step. This method is applicable to acid stable as well as acid sensitive compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63b07dd8c6b7ac2c407e21650bfa84f5
https://doi.org/10.1002/chin.200204227
https://doi.org/10.1002/chin.200204227
Publikováno v:
Antimicrobial agents and chemotherapy. 49(11)
Mycobacterium avium complex (MAC) is resistant to trimethoprim, an inhibitor of bacterial dihydrofolate reductase (DHFR). A previously identified selective inhibitor of MAC DHFR, SRI-8858, was shown to have synergistic activity in combination with da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b80f3b43999fd64dacce31d504ce07
https://pubmed.ncbi.nlm.nih.gov/16251337
https://pubmed.ncbi.nlm.nih.gov/16251337
Publikováno v:
Journal of medicinal chemistry. 45(25)
A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarbox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5df2f8504081e32a4eb42a29a197e4
https://pubmed.ncbi.nlm.nih.gov/12459027
https://pubmed.ncbi.nlm.nih.gov/12459027