CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity.

Autor: Nygård L; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Valta M; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Laine AP; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Toppari J; Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Pediatrics, Turku University Hospital, Turku, Finland., Knip M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Pediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland.; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland., Veijola R; Medical Research Center, Department of Pediatrics, PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Hyöty H; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories Ltd., Pirkanmaa Hospital District, Tampere, Finland., Ilonen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Lempainen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Pediatrics, Turku University Hospital, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland.

Publikováno v: Frontiers in genetics [Front Genet] 2023 Nov 02; Vol. 14, pp. 1248701. Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2023).

Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage.

Autor: Sioofy-Khojine AB; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Richardson SJ; Exeter Centre of Excellence for Diabetes Research (EXCEED), Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Locke JM; Exeter Centre of Excellence for Diabetes Research (EXCEED), Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Oikarinen S; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland., Nurminen N; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Laine AP; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Downes K; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; Cambridge University Hospitals Genomics Laboratory, Cambridge University Hospital NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK., Lempainen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Todd JA; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health and Care Research/Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Veijola R; Department for Children and Adolescents, Oulu University Hospital, Oulu, Finland.; Department of Paediatrics, Medical Research Center Oulu, University of Oulu, Oulu, Finland., Ilonen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Knip M; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Center for Child Health Research, Tampere University Hospital, Tampere, Finland., Morgan NG; Exeter Centre of Excellence for Diabetes Research (EXCEED), Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Hyöty H; Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.; Center for Child Health Research, Tampere University Hospital, Tampere, Finland., Peakman M; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK.; National Institute for Health Research, Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust, King's College London, London, UK., Eichmann M; Exeter Centre of Excellence for Diabetes Research (EXCEED), Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK. m.eichmann@exeter.ac.uk.; Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK. m.eichmann@exeter.ac.uk.

Publikováno v: Diabetologia [Diabetologia] 2022 Oct; Vol. 65 (10), pp. 1701-1709. Date of Electronic Publication: 2022 Jul 22.

Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects.

Autor: Laine AP; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Valta M; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Toppari J; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland.; Department of Paediatrics, University of Turku and Turku University Hospital, Turku, Finland., Knip M; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland., Veijola R; Department of Paediatrics, PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland.; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Ilonen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Lempainen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Department of Paediatrics, University of Turku and Turku University Hospital, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Jun 21; Vol. 13, pp. 909020. Date of Electronic Publication: 2022 Jun 21 (Print Publication: 2022).

Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood.

Autor: Lempainen J; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Korhonen LS; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland., Kantojärvi K; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Finnish Institute for Health and Welfare, Genomics and Biobank Unit, Helsinki, Finland.; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Heinonen S; New Children's Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Toivonen L; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland., Räty P; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland., Ramilo O; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Mejias A; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Laine AP; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland., Vuorinen T; Institute of Biomedicine, University of Turku and Department of Clinical Microbiology, Turku University Hospital, Turku, Finland., Waris M; Institute of Biomedicine, University of Turku and Department of Clinical Microbiology, Turku University Hospital, Turku, Finland., Karlsson L; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Child Psychiatry, University of Turku and Turku University Hospital, Turku, Finland., Karlsson H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland., Paunio T; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.; Finnish Institute for Health and Welfare, Genomics and Biobank Unit, Helsinki, Finland.; Department of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland., Peltola V; Department of Paediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2021 Jan 04; Vol. 223 (1), pp. 157-165.

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies.

Autor: Koskinen MK; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland maarit.koskinen@utu.fi.; Medicity, University of Turku, Turku, Finland., Mikk ML; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku and Clinical Microbiology, Turku University Hospital, Turku, Finland., Laine AP; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku and Clinical Microbiology, Turku University Hospital, Turku, Finland., Lempainen J; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku and Clinical Microbiology, Turku University Hospital, Turku, Finland., Löyttyniemi E; Department of Biostatistics, University of Turku, Turku, Finland., Vähäsalo P; Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Hekkala A; Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Härkönen T; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kiviniemi M; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku and Clinical Microbiology, Turku University Hospital, Turku, Finland., Simell O; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland., Knip M; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Center, Helsinki, Finland.; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland., Veijola R; Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland., Ilonen J; Immunogenetics Laboratory, Institute of Biomedicine, University of Turku and Clinical Microbiology, Turku University Hospital, Turku, Finland., Toppari J; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.

Publikováno v: Diabetes [Diabetes] 2020 Jan; Vol. 69 (1), pp. 12-19. Date of Electronic Publication: 2019 Oct 07.