Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laila Silamiķele"'
Autor:
Laila Silamiķele, Rihards Saksis, Ivars Silamiķelis, Patrīcija Paulīne Kotoviča, Monta Brīvība, Ineta Kalniņa, Zane Kalniņa, Dāvids Fridmanis, Jānis Kloviņš
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTAntidiabetic drug metformin alters the gut microbiome composition in the context of type 2 diabetes and other diseases; however, its effects have been mainly studied using fecal samples, which offer limited information about the intestinal si
Externí odkaz:
https://doaj.org/article/4a64372d4ca04d9dbf5867275cf17140
Autor:
Monta Brīvība, Laila Silamiķele, Ineta Kalniņa, Ivars Silamiķelis, Līga Birzniece, Laura Ansone, Lauma Jagare, Ilze Elbere, Jānis Kloviņš
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionResearch findings of the past decade have highlighted the gut as the main site of action of the oral antihyperglycemic agent metformin despite its pharmacological role in the liver. Extensive evidence supports metformin’s modulatory eff
Externí odkaz:
https://doaj.org/article/6beaf56def1b40759d3844d059c0a2ee
Autor:
Lilite Sadovska, Jānis Auders, Laura Keiša, Nadezhda Romanchikova, Laila Silamiķele, Madara Kreišmane, Pawel Zayakin, Satoru Takahashi, Zane Kalniņa, Aija Linē
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Increasing evidence suggests that regular physical exercise not only reduces the risk of cancer but also improves functional capacity, treatment efficacy and disease outcome in cancer patients. At least partially, these effects are mediated by the se
Externí odkaz:
https://doaj.org/article/231e6456437640969a019fbaf142bb42
Autor:
Laila Silamiķele, Ivars Silamiķelis, Monta Ustinova, Zane Kalniņa, Ilze Elbere, Ramona Petrovska, Ineta Kalniņa, Jānis Kloviņš
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of met
Externí odkaz:
https://doaj.org/article/fa70e258c0524c028c9f7a617c75e902
Autor:
Ineta Kalniņa, Jānis Kloviņš, Zane Kalniņa, Ilze Elbere, Monta Ustinova, Ramona Petrovska, Laila Silamiķele, Ivars Silamiķelis
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinology, Vol 12 (2021)
Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d199b23800c0efc1e8df1b0e7cb5cf
https://doi.org/10.1101/2020.10.30.362095
https://doi.org/10.1101/2020.10.30.362095
Autor:
Monta Ustinova, Raitis Peculis, Raimonds Rescenko, Vita Rovite, Linda Zaharenko, Ilze Elbere, Laila Silamikele, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Type 2 diabetes complications cause a serious emotional and economical burden to patients and healthcare systems globally. Management of both acute and chronic complications of diabetes, which dramatically impair the quality of pa
Externí odkaz:
https://doaj.org/article/eff6c95da64843748bc416c62dc2702e
Autor:
Nikita Zrelovs, Monta Ustinova, Ivars Silamikelis, Liga Birzniece, Kaspars Megnis, Vita Rovite, Lauma Freimane, Laila Silamikele, Laura Ansone, Janis Pjalkovskis, Davids Fridmanis, Baiba Vilne, Marta Priedite, Anastasija Caica, Mikus Gavars, Dmitry Perminov, Jelena Storozenko, Oksana Savicka, Elina Dimina, Uga Dumpis, Janis Klovins
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, Dec
Externí odkaz:
https://doaj.org/article/6fe67190413c4e4ca3599dfc8117311b
Autor:
Monta Ustinova, Laura Ansone, Ivars Silamikelis, Vita Rovite, Ilze Elbere, Laila Silamikele, Ineta Kalnina, Davids Fridmanis, Jelizaveta Sokolovska, Ilze Konrade, Valdis Pirags, Janis Klovins
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237400 (2020)
Metformin, a biguanide agent, is the first-line treatment for type 2 diabetes mellitus due to its glucose-lowering effect. Despite its wide application in the treatment of multiple health conditions, the glycemic response to metformin is highly varia
Externí odkaz:
https://doaj.org/article/be10e303651a4c3cafadde5947f85354
Autor:
Ilze Elbere, Ivars Silamikelis, Ilze Izabella Dindune, Ineta Kalnina, Monta Ustinova, Linda Zaharenko, Laila Silamikele, Vita Rovite, Dita Gudra, Ilze Konrade, Jelizaveta Sokolovska, Valdis Pirags, Janis Klovins
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241338 (2020)
BackgroundThe study was conducted to investigate the effects of metformin treatment on the human gut microbiome's taxonomic and functional profile in the Latvian population, and to evaluate the correlation of these changes with therapeutic efficacy a
Externí odkaz:
https://doaj.org/article/e224920880ab49b9ba65da927b75855c
Autor:
Laila Silamiķele, Rihards Saksis, Ivars Silamiķelis, Patrīcija Paulīne Kotoviča, Monta Brīvība, Ineta Kalniņa, Zane Kalniņa, Dāvids Fridmanis, Jānis Kloviņš
Publikováno v:
Gut Microbes. 15(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9fa355af846d8324b46795aca55000