Výsledky vyhledávání - "Laila H, Emara"

Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 33 Full Factorial Design Based on Response Surface Methodology

Autor: Maha F. Emam, Ahmed A. El-Ashmawy, Nadia M. Mursi, Laila H. Emara

Publikováno v: AAPS PharmSciTech. 23

This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a03485af0456c5e74dc1f135d7ee669c
https://doi.org/10.1208/s12249-022-02394-7

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Modulating Gliclazide Release and Bioavailability Utilizing Multiparticulate Drug Delivery Systems

Autor: Nadia M. Mursi, Ahmed A. El-Ashmawy, Laila H. Emara, Ebtesam W. Elsayed, Khaled Mahmoud

Publikováno v: Journal of Pharmaceutical Innovation. 17:674-689

To formulate multiparticulate controlled-release alginate-gelatin (AL-GL) beads in order to modify gliclazide (GLZ) release rate. AL-GL beads were prepared using different glutaraldehyde concentrations and dried using either air or freeze-drying meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c316313cfd727ab1d4962826525eb041
https://doi.org/10.1007/s12247-021-09542-9

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Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3

Autor: Maha F, Emam, Ahmed A, El-Ashmawy, Nadia M, Mursi, Laila H, Emara

Publikováno v: AAPS PharmSciTechREFERENCES. 23(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89935631a076e8a0905198964adebf85
https://pubmed.ncbi.nlm.nih.gov/36056201

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A novel combination of Soluplus®/Poloxamer for Meloxicam solid dispersions via hot melt extrusion for rapid onset of action. Part 2: comparative bioavailability and IVIVC

Autor: Nesrin F. Taha, Laila H. Emara, Maha F. Emam

Publikováno v: Drug Development and Industrial Pharmacy. 46:1362-1372

Bioavailability of Meloxicam (MLX) from solid dispersions (SDs), against innovator product Mobic® in humans was conducted. Furthermore, to establish a good in vitro–in vivo correlation (IVIVC); dis...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7977a012ccd88be9f6f31045fb2979a9
https://doi.org/10.1080/03639045.2020.1791164

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Novel Glyceryl Monostearate- and Polyethylene Glycol 6000-Based Ibuprofen Pellets Prepared by Hot-Melt Extrusion: Evaluation and Stability Assessment

Autor: Ahmed A. El-Ashmawy, Fatma M. Abdelfattah, Laila H. Emara

Publikováno v: Journal of Pharmaceutical Innovation.

Purpose To prepare stable sustained-release (SR) pellets, containing high ibuprofen (IBU) loading, by hot-melt extrusion (HME) technique using polyethylene glycol 6000 (PEG 6000) and glyceryl monostearate (GMS). Methods HME pellets (60% w/w IBU) were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e678c13124e98d68bf7697736a6c67aa
https://doi.org/10.1007/s12247-022-09647-9

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Convolution- and Deconvolution-Based Approaches for Prediction of Pharmacokinetic Parameters of Diltiazem Extended-Release Products in Flow-Through Cell Dissolution Tester

Autor: Nesrin F, Taha, Laila H, Emara

Publikováno v: AAPS PharmSciTech. 23(6)

The present study evaluated the effect of different configuration setups of the Flow-Through Cell (USP IV) dissolution tester in developing in vitro-in vivo correlation (IVIVC). A Biopharmaceutics Classification System (BCS) Class I Diltiazem (DTZ),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3d3ff4b7ded9856826bca5ed04ca0222
https://pubmed.ncbi.nlm.nih.gov/35882726

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COMPARATIVE IN VITRO DISSOLUTION STUDY ON METFORMIN MARKET PRODUCTS USING DIFFERENT DISSOLUTION APPARATUSES

Autor: Hanan M. Hashem, Nadia M. Mursi, Aya R. Abdou, Laila H. Emara

Publikováno v: International Journal of Pharmacy and Pharmaceutical Sciences. :65-72

Objective: This study was proposed to evaluate and compare the in vitro dissolution profiles of six Metformin Hydrochloride (MH) market products. Methods: Different dissolution apparatuses (USP apparatus II, IV and beaker method) were used to evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27fd9bbdc5f1d6b234942f03efe8dcab
https://doi.org/10.22159/ijpps.2019v11i9.34711

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Formulation, Pharmacokinetics evaluation, and IVIVC Assessment of Gliclazide Multiparticulates in Rat Model

Autor: Khaled Mahmoud, Ebtesam W. Elsayed, Nesrin F. Taha, Ahmed A. El-Ashmawy, Laila H. Emara, Aya R. Abdou

Publikováno v: AAPS PharmSciTech. 22

In vitro and in vivo studies of gliclazide (GLZ)-loaded freeze-dried alginate-gelatin (AL-GL) beads were carried out, aiming to modify its oral bioavailability. Crosslinked freeze-dried GLZ AL-GL beads (particle size: 1.5- and 3.0-mm) were prepared.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7919a157cc3d35713b4d3a28b1c71f16
https://doi.org/10.1208/s12249-021-02008-8

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