Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Laila, Kudsiova"'
Autor:
Lili Cui, Laila Kudsiova, Frederick Campbell, David J. Barlow, Helen C. Hailes, Alethea B. Tabor, M. Jayne Lawrence
Publikováno v:
Biomaterials Science. 11:3335-3353
Lipopolyplexes formulated from branched cationic peptides with cell receptor targeting sequences, DOTMA and DOPE, and plasmid DNA in the presence of saline form multilamellar nanoparticles with enhanced stability and transfection in serum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63ae9fbafedca6c3a9c14f46df47495
https://doi.org/10.1039/d2bm01905a
https://doi.org/10.1039/d2bm01905a
Autor:
Lucas D. Bowler, Sian Williams, M. D. Tarzi, Samantha Lippett, Marcus Allen, Alison B. Lansley, Greg Scutt, M Okorie, Michael Cross, Selma Stafford, Laila Kudsiova
Publikováno v:
BMJ Open Science, Vol 5, Iss 1 (2021)
BMJ Open Science
BMJ Open Science
Objective - The roll-out of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine has brought many logistical challenges, such as the absence of comprehensive stability data leading to strict handling instructions during dilution and administration. Accident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1c35bd51806ee128c380c52b2b8b43
https://openscience.bmj.com/content/5/1/e100203.full
https://openscience.bmj.com/content/5/1/e100203.full
Autor:
Laila, Kudsiova, Katharina, Welser, Frederick, Campbell, Atefeh, Mohammadi, Natalie, Dawson, Lili, Cui, Helen C, Hailes, M Jayne, Lawrence, Alethea B, Tabor
Publikováno v:
Molecular bioSystems. 12(3)
Ternary nanocomplexes, composed of bifunctional cationic peptides, lipids and siRNA, as delivery vehicles for siRNA have been investigated. The study is the first to determine the optimal sequence and architecture of the bifunctional cationic peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42697d630100e998865b844e4761e42e
https://pubmed.ncbi.nlm.nih.gov/26794416
https://pubmed.ncbi.nlm.nih.gov/26794416
Autor:
Eun-Ang Raiber, Stephen L. Hart, Helen C. Hailes, Anthony P. R. Brain, Tony Ng, M. Jayne Lawrence, Laila Kudsiova, Stephanie M. Grosse, Alice Warley, M. Firouz Mohd Mustapa, Alethea B. Tabor, John B. Wong, Hannah E. J. Armer, Martin Elbs, Melanie Keppler
Publikováno v:
Bioconjugate Chemistry. 20:518-532
Recent research in the field of nonviral gene delivery vectors has focused on preparing nanoparticles that are stabilized by the incorporation of a PEG coating and where one of the vector components is also cleavable. Here,we describe the synthesis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c5e0e4893c7f886292b557adb4c92d
https://doi.org/10.1021/bc800450r
https://doi.org/10.1021/bc800450r
Publikováno v:
Journal of Pharmaceutical Sciences. 97:3981-3997
Encapsulation of DNA (varying type and molecular weight) in vesicles (dehydration-rehydration vesicles; DRV) prepared from zwitterionic phospholipids using the dehydration-rehydration method was determined to be in the range of 10-90%. Encapsulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5662cf84648fb86a5ef41bb3cce35015
https://doi.org/10.1002/jps.21355
https://doi.org/10.1002/jps.21355
Autor:
Laila Kudsiova, Richard D. Harvey, David J. Barlow, M. Jayne Lawrence, Richard K. Heenan, Alex F. Drake, Anthony P. R. Brain
Publikováno v:
Journal of Colloid and Interface Science. 315:648-661
Encapsulation efficiencies of vesicles formed by the nonionic surfactant 1,2-dioctadecyl-rac-glycerol-3-ω-methoxydodecylethylene glycol (abbreviated as 2C18E12) and its phospholipid counterpart, distearoylphosphatidylcholine (DSPC) at 298 K, were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa06835c9951b38815831c71019a7f5
https://doi.org/10.1016/j.jcis.2007.06.076
https://doi.org/10.1016/j.jcis.2007.06.076
Autor:
Stephen L. Hart, Atefeh Mohammadi, Frederick Campbell, Alethea B. Tabor, Helen C. Hailes, David J. Barlow, Katharina Welser, Natalie L. Dawson, M. Jayne Lawrence, Laila Kudsiova
Publikováno v:
Molecular pharmaceutics. 10(1)
Cationic peptide sequences, whether linear, branched, or dendritic, are widely used to condense and protect DNA in both polyplex and lipopolyplex gene delivery vectors. How these peptides behave within these particles and the consequences this has on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19306060c49dbe9d684f171e68439a19
https://pubmed.ncbi.nlm.nih.gov/23210981
https://pubmed.ncbi.nlm.nih.gov/23210981
Autor:
Katarzyna Witt, Poulami Chaudhuri, Wanling Liang, Yun Lan, Michael Y.T. Chow, Jenny K.W. Lam, A. James Mason, Laila Kudsiova
Cationic amphipathic histidine rich peptides possess high plasmid DNA and siRNA delivery capabilities. To further understand the pH responsive siRNA delivery process and evaluate the capabilities of such peptides we have investigated their ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68fe6f5862067c98a50d4a2a70d172d
http://hdl.handle.net/10722/146797
http://hdl.handle.net/10722/146797
Autor:
Alethea B. Tabor, Frederick Campbell, M. Jayne Lawrence, Barbara Fridrich, M. Firouz Mohd Mustapa, Katharina Welser, Tony Ng, Jimmy Ho, Helen C. Hailes, Laila Kudsiova, David J. Barlow, Melanie Keppler
Publikováno v:
Molecular pharmaceutics. 8(5)
The structure, biophysical properties and biological behavior of lipopolyplex ternary gene delivery vectors incorporating novel C14 glycerol based lipids of varying alkyl chain geometry (containing cis, trans or alkyne double bonds) have been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9c4899fa4fcd2e44e70cee0bdf5041
https://pubmed.ncbi.nlm.nih.gov/21815622
https://pubmed.ncbi.nlm.nih.gov/21815622
Autor:
Tony Ng, Jimmy Ho, Stephen L. Hart, Melanie Keppler, Laila Kudsiova, Richard D. Harvey, Helen C. Hailes, M. Jayne Lawrence, Barbara Fridrich, Alethea B. Tabor
Publikováno v:
Molecular bioSystems. 7(2)
The effects have been determined of a systematic alteration of the alkyl chain geometry of a C14 analogue of DOTMA on the detailed molecular architecture of the resulting cationic vesicles formed both in the absence and presence of 50 mol% DOPE, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47b4b7cc8dd97807014649a7a9ded3a
https://pubmed.ncbi.nlm.nih.gov/21057687
https://pubmed.ncbi.nlm.nih.gov/21057687