Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laia Richart"'
Autor:
Pierre Romero, Laia Richart, Setareh Aflaki, Ambre Petitalot, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Samuel Le Cam, Carlos Baliñas-Gavira, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to tumor type. This specificity is poorly understood
Externí odkaz:
https://doaj.org/article/1b39f7921f8b45b382015dc3a19b069d
Autor:
Laia Richart, Enrique Carrillo-de Santa Pau, Ana Río-Machín, Mónica P. de Andrés, Juan C. Cigudosa, Víctor J. Sánchez-Arévalo Lobo, Francisco X. Real
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
c-MYC genomic distribution is dictated by the epigenetic context but the mechanisms are unknown. Here, the authors show that c-MYC requires the chromatin reader BPTF to activate its transcriptional program and promote tumour development in vivo, sugg
Externí odkaz:
https://doaj.org/article/9e41642534ff4cecb91d4e1d757e9e25
Autor:
Pierre Romero, Laia Richart, Setareh Aflaki, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron
Mutations in chromatin regulators or their histone substrates are widespread in cancer and often play decisive roles in tumorigenesis. These include Polycomb Repressive Complex 2 (PRC2), a histone H3 lysine 27 methyltransferase that shows distinct al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cccdbebd006a04c359ddf5872a66b82
https://doi.org/10.1101/2023.01.02.522460
https://doi.org/10.1101/2023.01.02.522460
Publikováno v:
Oncogene. 40:3475-3491
Enhancers are cis-regulatory sequences that fine-tune expression of their target genes in a spatiotemporal manner. They are recognized by sequence-specific transcription factors, which in turn recruit transcriptional coactivators that facilitate tran
Autor:
Almudena R. Ramiro, Irene Felipe, Laia Richart, Juan F. García, Natalia del Pozo, Miguel A. Piris, Francisco X. Real, Jaime Prieto, Pilar Delgado, Mónica P. de Andrés
Publikováno v:
Oncogene. 39:4884-4895
Chromatin remodeling factors contribute to establish aberrant gene expression programs in cancer cells and therefore represent valuable targets for therapeutic intervention. BPTF (Bromodomain PhD Transcription Factor), a core subunit of the nucleosom
Autor:
Laia Richart, Mary-Loup Picod-Chedotel, Michel Wassef, Manon Macario, Setareh Aflaki, Marion A. Salvador, Tiphaine Héry, Aurélien Dauphin, Julien Wicinski, Véronique Chevrier, Sonia Pastor, Geoffrey Guittard, Samuel Le Cam, Hanya Kamhawi, Rémy Castellano, Géraldine Guasch, Emmanuelle Charafe-Jauffret, Edith Heard, Raphaël Margueron, Christophe Ginestier
Publikováno v:
Cell
Cell, 2022, 185 (12), pp.2164-2183.e25. ⟨10.1016/j.cell.2022.04.034⟩
Cell, 2022, 185 (12), pp.2164-2183.e25. ⟨10.1016/j.cell.2022.04.034⟩
X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis, promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is only beginning to be elucidated. Here, we demonstrate that XIST
Autor:
Christophe Ginestier, Emmanuelle Charafe-Jauffret, Mary-Loup Picod, Géraldine Guasch, Michel Wassef, Julien Wicinski, Setareh Aflaki, Edith Heard, Raphaël Margueron, Laia Richart, Véronique Chevrier, Samuel Le Cam, Manon Macario, Hanya A. Kamhawi, Marion A. Salvador, Rémy Castellano
Publikováno v:
SSRN Electronic Journal.
X-chromosome inactivation (XCI) is triggered by up-regulation of XIST, which coats the chromosome in cis and promotes recruitment of chromatin modifiers that transform the X into a silent heterochromatic domain. Whether XIST plays a role beyond initi
Autor:
Yasmina Cuartero, Alfonso Valencia, F. Radvanyi, Vera Pancaldi, Marc A. Marti-Renom, Miguel Madrid-Mencía, Enrique Carrillo-de-Santa Pau, Francisco X. Real, François Serra, Juan Antonio Rodríguez, Eleonora Lapi, Hélène Neyret-Kahn, François Le Dily, Mirabai Cuenca-Ardura, Laia Richart
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, ⟨10.1093/nar/gkab864⟩
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Instituto de Salud Carlos III (ISCIII)
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2021, ⟨10.1093/nar/gkab864⟩
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, we analyze the genomic dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284738d186c887ef6a9c316a8a876eaa
http://hdl.handle.net/10230/52354
http://hdl.handle.net/10230/52354
Autor:
Pierre Savatier, Nuria Montserrat, Laia Richart-Ginés, Camille Stephan-Otto Attolini, Raquel Bernad, Susana Prieto, Marta I. Sierra, Joaquín Pastor, Magdalena Zernicka-Goetz, Sonia Sánchez Martínez, Daniel Fisher, Javier Munoz, Sandrina Nóbrega-Pereira, Noelia Alcazar, Ana Martinez-Val, Gonzalo Gómez-López, Mario F. Fraga, Marta N. Shahbazi, Elisabeth Simboeck, Carmen Blanco-Aparicio, Elena Garreta, Osvaldo Graña-Castro, Alain Camasses, Irène Aksoy, Sagrario Ortega, Cian J. Lynch, Maribel Muñoz-Martin, Isabel A. Calvo, Agustín F. Fernández, Manuel Serrano, Carolina Tarantino
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Cell Biology, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
research@ua; Vol 11 (2020); 49
research@ua; vol. 11 (2020); 49
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Cell Biology, Nature Publishing Group, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Cell Biology, 2020, 22 (10), pp.1223-1238. ⟨10.1038/s41556-020-0573-1⟩
research@ua; Vol 11 (2020); 49
research@ua; vol. 11 (2020); 49
Digital.CSIC. Repositorio Institucional del CSIC
instname
Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental changes in the early embryo. PSCs can be stabilized in the naive state by blocking extracellular differentiation stimuli, particularly FGF–MEK signallin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e6662dbd5d60ba17897bdaeae5b24d
https://hal.archives-ouvertes.fr/hal-03234133
https://hal.archives-ouvertes.fr/hal-03234133
Autor:
Mirabai Cuenca, Marc A. Marti-Renom, Yasmina Cuartero, François Le Dily, Alfonso Valencia, Francisco X. Real, François Serra, Enrique Carrillo-de-Santa Pau, Juan Antonio Rodríguez, Laia Richart, Eleonora Lapi, Hélène Neyret-Kahn, Miguel Madrid-Mencía, F. Radvanyi, Vera Pancaldi
Cohesin exists in two variants, containing either STAG1 or STAG2. STAG2 is one of the most commonly mutated genes in human cancer, and a major bladder cancer tumor suppressor. Little is known about how its inactivation contributes to tumor developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3db6b96ea520fdf867e97d09d84a4ccc
https://doi.org/10.1101/2020.08.06.240457
https://doi.org/10.1101/2020.08.06.240457