Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Laia, Albiol"'
Autor:
Elizabeth A. Zimmermann, Taylor DeVet, Myriam Cilla, Laia Albiol, Kyle Kavaseri, Christine Andrea, Catherine Julien, Kerstin Tiedemann, Arash Panahifar, Sima A. Alidokht, Richard Chromik, Svetlana V. Komarova, Dieter P. Reinhardt, Paul Zaslansky, Bettina M. Willie
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100155- (2024)
Marfan syndrome (MFS) is a connective tissue disorder caused by pathogenic mutations in FBN1. In bone, the protein fibrillin-1 is found in the extracellular matrix where it provides structural support of elastic fiber formation, stability for basemen
Externí odkaz:
https://doaj.org/article/11dca0b7ed3548aea96d0ff568f474c8
Autor:
Haisheng Yang, Alexander Büttner, Laia Albiol, Catherine Julien, Tobias Thiele, Christine Figge, Ina Kramer, Michaela Kneissel, Georg N. Duda, Sara Checa, Bettina M. Willie
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Abstract Loss-of-function mutations in the Sost gene lead to high bone mass phenotypes. Pharmacological inhibition of Sost/sclerostin provides a new drug strategy for treating osteoporosis. Questions remain as to how physical activity may affect bone
Externí odkaz:
https://doaj.org/article/1dceab63af8746c094663a625e692c5c
Autor:
Alexander Büttner, Ina Kramer, Catherine Julien, Laia Albiol, Michaela Kneissel, Haisheng Yang, Bettina M. Willie, Christine Figge, Georg N. Duda, Sara Checa, Tobias Thiele
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Loss-of-function mutations in the Sost gene lead to high bone mass phenotypes. Pharmacological inhibition of Sost/sclerostin provides a new drug strategy for treating osteoporosis. Questions remain as to how physical activity may affect bone mass und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b73969534460094c94db3b993ffa26d
https://doaj.org/article/1dceab63af8746c094663a625e692c5c
https://doaj.org/article/1dceab63af8746c094663a625e692c5c
Autor:
Alexander Büttner, Michaela Kneissel, Laia Albiol, Ina Kramer, Annette Birkhold, David Pflanz, Georg N. Duda, Bettina M. Willie, Nicholas Mikolajewicz, Sara Checa
Publikováno v:
Calcified Tissue International. 106:415-430
A new therapeutic option to treat osteoporosis is focused on Wnt signaling and its inhibitor sclerostin, a product of the Sost gene. In this work, we study the effect of sclerostin deficiency on trabecular bone formation and resorption in male and fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addd2362a3c4d40f90a0c568a58127e7
https://doi.org/10.1007/s00223-019-00648-4
https://doi.org/10.1007/s00223-019-00648-4
Autor:
Marcel Dreischarf, Laia Albiol, Antonius Rohlmann, Esther Pries, Maxim Bashkuev, Thomas Zander, Georg Duda, Claudia Druschel, Patrick Strube, Michael Putzier, Hendrik Schmidt
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116186 (2014)
BACKGROUND:The understanding of the individual shape and mobility of the lumbar spine are key factors for the prevention and treatment of low back pain. The influence of age and sex on the total lumbar lordosis and the range of motion as well as on d
Externí odkaz:
https://doaj.org/article/3148b9d99a9249eab721a8e66a35d87b
Autor:
Uwe Kornak, Bettina M. Willie, Wing Lee Chan, Sara Checa, Michael Thelen, Lyudmila Spevak, Laia Albiol, Dag Wulsten, Adele L. Boskey, Tobias Thiele, Haisheng Yang, Anne Seliger
Publikováno v:
Journal of Biomechanics. 65:145-153
Gerodermia osteodysplastica (GO) is a segmental progeroid disorder caused by loss-of-function mutations in the GORAB gene, associated with early onset osteoporosis and bone fragility. A conditional mouse model of GO (GorabPrx1) was generated in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0599d77080a11ee2462a762546ffb9
https://doi.org/10.1016/j.jbiomech.2017.10.018
https://doi.org/10.1016/j.jbiomech.2017.10.018
Autor:
Laia Albiol, Michaela Kneissel, Sara Checa, Georg N. Duda, David Pflanz, Ina Kramer, Myriam Cilla, Bettina M. Willie
Sclerostin, a product of the Sost gene, is a Wnt-inhibitor and thus negatively regulates bone accrual. Canonical Wnt/β-catenin signalling is also known to be activated in mechanotransduction. Sclerostin neutralizing antibodies are being tested in on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d14e11809ba527fdb795a8afbff68f5
https://europepmc.org/articles/PMC5938586/
https://europepmc.org/articles/PMC5938586/
Autor:
Haisheng, Yang, Laia, Albiol, Wing-Lee, Chan, Dag, Wulsten, Anne, Seliger, Michael, Thelen, Tobias, Thiele, Lyudmila, Spevak, Adele, Boskey, Uwe, Kornak, Sara, Checa, Bettina M, Willie
Publikováno v:
Journal of biomechanics. 65
Gerodermia osteodysplastica (GO) is a segmental progeroid disorder caused by loss-of-function mutations in the GORAB gene, associated with early onset osteoporosis and bone fragility. A conditional mouse model of GO (GorabPrx1) was generated in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb3a3a2eaf48e13f958c28109cf8e03e
https://pubmed.ncbi.nlm.nih.gov/29108851
https://pubmed.ncbi.nlm.nih.gov/29108851
Autor:
Ina Kramer, Michaela Kneissel, Uwe Kornak, Georg N. Duda, Catherine Julien, Annette Birkhold, David Pflanz, Anne Seliger, Sara Checa, Bettina M. Willie, Tobias Thiele, Erin Thomson, Laia Albiol
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
BASE-Bielefeld Academic Search Engine
Scientific Reports
BASE-Bielefeld Academic Search Engine
Scientific Reports
Bone adaptation optimizes mass and structure, but the mechano-response is already reduced at maturation. Downregulation of sclerostin was believed to be a mandatory step in mechano-adaptation, but in young mice it was shown that load-induced formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9478ff1b0fe68c5acfadde5b56ce69ab
Autor:
Georg Bergmann, Rizwan Arshad, Marcel Dreischarf, Thomas Zander, Hendrik Schmidt, Antonius Rohlmann, Friedmar Graichen, Laia Albiol
Publikováno v:
Journal of biomechanics. 48(4)
Knowledge about in vivo spinal loads is required for the identification of risk factors for low back pain and for realistic preclinical testing of spinal implants. Therefore, the aim of the present study was to measure the in vivo forces on a vertebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf14895116cd4cc9dbceab6a038ecd9
https://pubmed.ncbi.nlm.nih.gov/25640900
https://pubmed.ncbi.nlm.nih.gov/25640900