Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

Autor: Yufeng Wang, David L. Drum, Ruochuan Sun, Yida Zhang, Feng Chen, Fengfei Sun, Emre Dal, Ling Yu, Jingyu Jia, Shahrzad Arya, Lin Jia, Song Fan, Steven J. Isakoff, Allison M. Kehlmann, Gianpietro Dotti, Fubao Liu, Hui Zheng, Cristina R. Ferrone, Alphonse G. Taghian, Albert B. DeLeo, Marco Ventin, Giulia Cattaneo, Yongxiang Li, Youssef Jounaidi, Peigen Huang, Cristina Maccalli, Hanyu Zhang, Cheng Wang, Jibing Yang, Genevieve M. Boland, Ruslan I. Sadreyev, LaiPing Wong, Soldano Ferrone, Xinhui Wang

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target antig

Externí odkaz: https://doaj.org/article/cdd6a0e581e24892b09297cc99e43a32

Genetic insights into juvenile idiopathic arthritis derived from deep whole genome sequencing

Autor: Laiping Wong, Kaiyu Jiang, Yanmin Chen, James N. Jarvis

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)

Abstract Deep whole genome sequencing (WGS) allows for the comprehensive study of genetic landscapes at finer resolution than array based methods. We conducted deep WGS on children with the polyarticular form of juvenile idiopathic arthritis (JIA), u

Externí odkaz: https://doaj.org/article/965e638a5bbf47e59d5e76bd567ec857

Additional file 8: of Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer

Autor: Liu, Song, Matsuzaki, Junko, Wei, Lei, Takemasa Tsuji, Battaglia, Sebastiano, Hu, Qiang, Cortes, Eduardo, Laiping Wong, Yan, Li, Long, Mark, Miliotto, Anthony, Bateman, Nicholas, Shashikant Lele, Thinle Chodon, Koya, Richard, Yao, Song, Qianqian Zhu, Conrads, Thomas, Jianmin Wang, Maxwell, George, Lugade, Amit, Kunle Odunsi

Figure S8. Characterization of JAK1 neoepitope-specific CD4+ T-cells. (a) Peptide reactivity of a JAK1 neoepitope-specific CD4+ T-cell line. IFN-γ and GM-CSF production on CD4+ T-cells against JAK1 mutated (IEILRNLYHEIIV) or wild-type (IEILRNLYHENIV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e489dc812489c2f51446670bcf42df1c

Proceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting

Autor: Peggy Lee, Victor Hasselblad, Anja Schnabel, Timo Siepmann, Liza Bermudez, Ting Wang, Gloria C. Higgins, Ann M. Reed, Reinhard Berner, Katharine Moore, Sriharsha Grevich, Amy J. Starr, Jerome C. Lane, Mark F. Hoeltzel, Emily von Scheven, Yvonne Chiu, Brian M. Feldman, Edward J Oberle, Susan Kim, Laurence Greenbaum, Adam M. Huber, Judyann C. Olson, Suzanne Li, Lorie Luyrink, Elizabeth Roth Wojcicki, Dana Toib, Doruk Erkan, Michelle Bayer, Rie Karasawa, Lynn Spiegel, Charles Victor, Polly J. Ferguson, T. Brent Graham, Mark Connelly, James N. Jarvis, Laura B Lewandowski, Jacinthe Bisaillon, Elizabeth D. Mellins, Stephanie Luca, Gloria Higgins, Suhas Ganguli, Mary Hintermeyer, Jennifer E. Weiss, Jessica Foster, Phillip I. Tarr, Timothy S. H. Kwok, Kristyn L. Maletta, Christine Smith, Mileka Gilbert, Shirley M. L. Tse, L. Nandini Moorthy, Ciaran Duffy, Beatrice Goilav, Kevin Baszis, Rayfel Schneider, Marc D. Natter, Martha Rodriguez, Chitra Lalloo, Yukiko Kimura, Rob C. Fuhbrigge, Eleanor Pullenayegum, Megan L. Curran, Hernan Correa, Colleen K. Correll, Cassyanne L. Aguiar, Suzanne C. Li, Khaled Alsaeid, Laura Brungs, Tim Beukelman, Sampath Prahalad, Susan D. Thompson, Xiaohu Li, Brian Best, Tao Liu, Stacey M. Martinetti, Kevin W. Baszis, Alexis Boneparth, Monica Tsoras, Darshan H. Mehta, Anne M. Stevens, Annabelle N. Chua, Sangeeta Sule, Gretchen R. Heckel, Argerie Tsimicalis, Lucie Brosseau, Helen Bristow, Sarah Ringold, Thomas G. Mason, Mara L. Becker, Laura E. Schanberg, Ezra M. Cohen, Kaiyu Jiang, Yonit Sterba Ruas, Katie Stewart, Anne Dennos, Alexei A. Grom, Kalpana Manthiram, Yanmin Chen, Joshua Newsom, Peter R. Blier, Jennifer M. P. Woo, Lori B. Tucker, Michelle L. Dossett, Deirdre De Ranieri, Ginger Janow, Nicole Johnson, Hatice Ezgi Baris, Andrew H. Eichenfield, Laiping Wong, Pamela F. Weiss, Marisa S. Klein-Gitelman, Esi M. Morgan, Jennifer Stinson, Christian M. Hedrich, Ashlea Cook, Marsha M. Malloy, Megan Yuasa, M.S.C.E. Mara Becker M.D., Patrick J. McGrath, Max Shenberger, Beth Gottlieb, Daryl M. Okamura, Timothy Beukelman, Esra Meidan, Natasha M. Ruth, Lisha Zhu, Kazuo Yudoh, Kelly L. Mieszkalski, James A. Jegers, Mayumi Tamaki, Peter A. Nigrovic, Karen Onel, Christiaan Scott, Linda Wagner-Weiner, Kader Cetin Gedik, Ursula Range, Vikas R. Dharnidharka, Melissa S Tesher, Daniel J. Lovell, Jason Dare, Natalie J. Shiff, Karine Toupin April, Soko Setoguchi, Michael J. Buck, Yvonne C. Lee, Nadia Luca, Sarah Campillo, Suhas M. Radhakrishna, Lauren J. Lahey, Anna Carmela P. Sagcal-Gironella, Brandi Stevens, William H. Robinson, Hazim Alsaeed, Rachel Kaufmann, Anca D. Askanase, Stacy P. Ardoin, Egla Rabinovich, Paul Dancey, Kathryn S. Torok, Norm Ilowite, Elizabeth L. Roth-Wojcicki, Mario Medvedovic, Brian G. Leroux, Thomas A. Griffin, Megumi Tanaka, Richard K. Vehe, Lampros Fotis, Ronald M. Laxer, Salma Siddique, Joyce Hui-Yuen, Marilynn Punaro, Roberta A. Berard, Gabriele Hahn, Halima Moncrieffe, Kathryn M. Edwards, Dominic O. Co, Lauren Harris, Hannah Leahey, George Tomlinson, Maria Ibarra, Ciarán M. Duffy, Sarah Thomson, Jeremy Sokolove, Stacy Ardoin, Sandy D. Hong, Fatma Dedeoglu, Dustin J. Hahn, Nur Shaikh, Y. Ingrid Goh, Amir B. Orandi, Margalit Rosenkranz, Naweed Tajuddin, Elena Pope, Grendel Burrell, Shannon Carr, C. Egla Rabinovich, Jasim Alfailakawi, Roger Davis, Anabelle Chua, Toshiko Sato, Kathleen M. O'Neil, Anthony R. French, Lisa Imundo, Paula Morris, Joseph A Cafazzo, Maria F. Ibarra, Scott E. Wenderfer, Tamar Rubinstein, Danielle R. Bullock, Huan Xu, Joyce J. Hsu, Ritesh Korumilli, Hamid Alenezi, Julia Barsalou, John Matelski, Nicole Hershey, Heather Van Mater, Marsha Malloy, Lei Zhang, Mark F. Bennett

Publikováno v: Pediatric Rheumatology. 14

Author(s): Fotis, Lampros; Shaikh, Nur; Baszis, Kevin; French, Anthony; Tarr, Phillip; Grevich, Sriharsha; Lee, Peggy; Ringold, Sarah; Leroux, Brian; Leahey, Hannah; Yuasa, Megan; Foster, Jessica; Sokolove, Jeremy; Lahey, Lauren; Robinson, William; N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4822422a9056e826528ba4aa7125d3a
https://doi.org/10.1186/s12969-016-0098-0

Whole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis.

Autor: Kaiyu Jiang, Laiping Wong, Sawle, Ashley D., Frank, M. Barton, Yanmin Chen, Wallace, Carol A., Jarvis, James N.

Publikováno v: Arthritis Research & Therapy; 7/7/2016, Vol. 18, p1-11, 11p