Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lai-shun Chen"'
Autor:
Qing-hua Li, Lai-shun Chen, Yasushi Yamazoe, M Ueda, Toshiharu Tsuzuki, Ryuichi Kato, Joyce A. Goldstein, Toshio Yasumori
Publikováno v:
Biochemical Pharmacology. 57:1297-1303
Regio- and stereoselective hydroxylation of phenytoin was determined in liver microsomes of nine extensive (EM) and three poor metabolizers (PM) of mephenytoin. Hydroxyphenytoins (HPPH) were isolated and quantified after separation into four regio- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac9e404809e97d188e7f422984d2402
https://doi.org/10.1016/s0006-2952(99)00034-9
https://doi.org/10.1016/s0006-2952(99)00034-9
Autor:
Kiyoshi Nagata, Toshio Yasumori, Shen K. Yang, Yasushi Yamazoe, Ryuichi Kato, Norie Murayama, Lai-shun Chen
Publikováno v:
Pharmacogenetics. 3:291-301
Metabolism of diazepam (DZP) was studied in vitro to clarify the involvement of different forms of hepatic cytochrome P450 (CYP) in rats, and humans of Japanese and Caucasian origin. Microsomal 3-hydroxylation was the major pathway of DZP metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34485cf47c6c213f189be78cf4951cd3
https://doi.org/10.1097/00008571-199312000-00003
https://doi.org/10.1097/00008571-199312000-00003
Publikováno v:
Pharmacogenetics. 3(2)
Microsomal hydroxylation of tolbutamide in Japanese livers was studied in vitro to ascertain the enzyme catalysing this reaction. Rates of tolbutamide hydroxylation differed individually 33-fold and 42-fold at 0.1 mM and 2.4 mM tolbutamide concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4fafecf5f3f8dd46d40c15ae6d8667
https://pubmed.ncbi.nlm.nih.gov/8518837
https://pubmed.ncbi.nlm.nih.gov/8518837
Autor:
Norie Murayama, Ryuichi Kato, Kiyoshi Nagata, Lai-shun Chen, Yasushi Yamazoe, Toshio Yasumori, Shen K. Yang
Publikováno v:
Japanese Journal of Pharmacology. 64:347
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8631ad977a935b0bd10b287f1b4ff736
https://doi.org/10.1016/s0021-5198(19)51023-x
https://doi.org/10.1016/s0021-5198(19)51023-x
Publikováno v:
Japanese Journal of Pharmacology. 58:332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5cb194d4acd0b94aec8b9554680a924
https://doi.org/10.1016/s0021-5198(19)49489-4
https://doi.org/10.1016/s0021-5198(19)49489-4