Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Lai-King Sy"'
Autor:
I-Sheng Chang, Chun-Nam Lok, Yi-Man Eva Fung, Ching Tung Lum, Wai-Lun Kwong, Bei Cao, Lai-King Sy, Chi-Ming Che
Publikováno v:
Journal of proteome research. 17(7)
Dehydroeffusol (DHE) is a phenanthrene isolated from the Chinese medicinal plant Juncus effusus. Biological evaluation of DHE reveals in vitro and in vivo anticancer effects. We performed a shotgun proteomic analysis using liquid chromatography-tande
Publikováno v:
Journal of Biological Chemistry. 286:31684-31696
Chemical modulators of autophagy provide useful pharmacological tools for examination of autophagic processes, and also may lead to new therapeutic agents for diseases in which control of cellular sequestration and degradation capacity are beneficial
Publikováno v:
Wuhan University Journal of Natural Sciences. 13:239-246
The morphologic and microscopic features of Radix et Rhizoma Rhei were studied. The study verified that the mucilage cavities did exist in phloem of rhizomes and roots or abnormal vascular bundles. Also, they were in similar distribution in three spe
Autor:
Geoffrey D. Brown, Lai-King Sy
Publikováno v:
Tetrahedron. 63:9536-9547
[15-(CH3)-C-13-H-2]-dihydro-epi-deoxyarteannuin B (4a) has been fed to intact Artemisia annua plants via the root and three labeled metabolites (17a-19a) have been identified by 1D- and 2D-NMR spectroscopies. The in vivo transformations of 4a in A. a
Autor:
Geoffrey D. Brown, Lai-King Sy
Publikováno v:
Tetrahedron. 63:9548-9566
Autor:
Lai-King Sy, Juan-Yu Wang, Chi-Ming Che, Chi-Ting Leung, Pui-Ki Wan, Bei Cao, Chun-Nam Lok, Yungen Liu, Lu Cheng, Wai-Lun Kwong, Raymond Chuen-Chung Chang
Publikováno v:
Chemical Science
The “sarsasapogenin-aglyconed” timosaponins are Aβ lowering agents that may be useful for the development of Alzheimer’s disease therapeutics.
The inhibition of amyloid β (Aβ) peptide production is a key approach in the development of t
The inhibition of amyloid β (Aβ) peptide production is a key approach in the development of t
Autor:
Geoffrey D. Brown, Lai-King Sy
Publikováno v:
Tetrahedron. 60:1139-1159
Artemisinic acid labeled with both 13 C and 2 H at the 15-position has been fed to intact plants of Artemisia annua via the cut stem, and its in vivo transformations studied by 1D- and 2D-NMR spectroscopy. Seven labeled metabolites have been isolated
Autor:
Lai-King Sy, Geoffrey D. Brown
Publikováno v:
Tetrahedron. 60:1125-1138
[15-(CH3)-C-13-H-2]-Dihydroartemisinic acid (2a), [15-(CH3)-H-2]-dihydroartemisinic acid (2b) and [15-(CH3)-C-13]-dihydroartemisinic acid (2c) have been obtained in good yield and high isotopic enrichment by a reconstructive synthesis from artemisini
Autor:
Lai-King Sy, Geoffrey D. Brown
Publikováno v:
Tetrahedron. 58:909-923
Three of the four steps in the slow spontaneous autoxidation of dihydroartemisinic acid to artemisinin (‘ene-type’ reaction of molecular oxygen with the Δ4,5 double bond, Hock cleavage of the resulting tertiary allylic hydroperoxide, oxygenation
Autor:
Lai-King Sy, Geoffrey D. Brown
Publikováno v:
Tetrahedron. 58:897-908
Dihydroartemisinic acid undergoes slow spontaneous autoxidation to artemisinin and other natural products, which have been reported from the medicinal plant Artemisia annua. The mechanism of this complex transformation is shown to involve four steps: