Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Lai Yee Leung"'
Autor:
Xue Li, Kevin Pierre, Zhihui Yang, Lynn Nguyen, Gabrielle Johnson, Juliana Venetucci, Isabel Torres, Brandon Lucke-Wold, Yuan Shi, Angela Boutte, Deborah Shear, Lai Yee Leung, Kevin K.W. Wang
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 370-380 (2021)
Penetrating traumatic brain injury (pTBI) often occurs with systemic insults such as hemorrhagic shock (HS) and hypoxemic (HX). This study examines rat models of penetrating ballistic-like brain injury (PBBI) and HX+HS to assess whether the blood lev
Externí odkaz:
https://doaj.org/article/26e60877b75b434d89d38c5ee3684ebe
Autor:
Zachary S. Bailey, Katherine Cardiff, Xiaofang Yang, Janice Gilsdorf, Deborah Shear, Todd E. Rasmussen, Lai Yee Leung
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Trauma is among the leading causes of death in the United States. Technological advancements have led to the development of resuscitative endovascular balloon occlusion of the aorta (REBOA) which offers a pre-hospital option to non-compressible hemor
Externí odkaz:
https://doaj.org/article/ba235a90933e4e649edcbd78e8358f19
Autor:
Ying Deng-Bryant, Lai Yee Leung, Sindhu Madathil, Jesse Flerlage, Fangzhou Yang, Weihong Yang, Janice Gilsdorf, Deborah Shear
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Close-head concussive injury, as one of the most common forms of traumatic brain injury (TBI), has been shown to induce cognitive deficits that are long lasting. A concussive impact model was previously established in our lab that produces clinically
Externí odkaz:
https://doaj.org/article/039b7c6274c74123aeafa7a09663e999
Autor:
Jignesh D. Pandya, Lai Yee Leung, Xiaofang Yang, William J. Flerlage, Janice S. Gilsdorf, Ying Deng-Bryant, Deborah A. Shear
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Mitochondria constitute a central role in brain energy metabolism, and play a pivotal role in the development of secondary pathophysiology and subsequent neuronal cell death following traumatic brain injury (TBI). Under normal circumstances, the brai
Externí odkaz:
https://doaj.org/article/0326c523cc144c7b8948aeff20bd7916
Autor:
Anelia A. Y. Kassi, Anil K. Mahavadi, Angelica Clavijo, Daniela Caliz, Stephanie W. Lee, Aminul I. Ahmed, Shoji Yokobori, Zhen Hu, Markus S. Spurlock, Joseph M Wasserman, Karla N. Rivera, Samuel Nodal, Henry R. Powell, Long Di, Rolando Torres, Lai Yee Leung, Andres Mariano Rubiano, Ross M. Bullock, Shyam Gajavelli
Publikováno v:
Frontiers in Neurology, Vol 9 (2019)
Traumatic brain injury (TBI) is the largest cause of death and disability of persons under 45 years old, worldwide. Independent of the distribution, outcomes such as disability are associated with huge societal costs. The heterogeneity of TBI and its
Externí odkaz:
https://doaj.org/article/14e9979ab1d64a7c9bf0ca834d0cfa43
Autor:
Sindhu K. Madathil, Bernard S. Wilfred, Sarah E. Urankar, Weihong Yang, Lai Yee Leung, Janice S. Gilsdorf, Deborah A. Shear
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Microglial activation is a pathological hallmark of traumatic brain injury (TBI). Following brain injury, activated microglia/macrophages adopt different phenotypes, generally categorized as M-1, or classically activated, and M-2, or alternatively ac
Externí odkaz:
https://doaj.org/article/4b51e09e42894aa4835307f63f363c5c
Autor:
Lai Yee Leung, Katherine Cardiff, Xiaofang Yang, Bernard Srambical Wilfred, Janice Gilsdorf, Deborah Shear
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Selective brain cooling (SBC) can potentially maximize the neuroprotective benefits of hypothermia for traumatic brain injury (TBI) patients without the complications of whole body cooling. We have previously developed a method that involved extralum
Externí odkaz:
https://doaj.org/article/1d725fcd4f9c40a195d4921969953014
Autor:
Xiaofang Yang, Jignesh D. Pandya, Hye Hwang, Ying Deng-Bryant, Lai Yee Leung, Deborah A. Shear
Publikováno v:
Journal of Neurotrauma. 38:2323-2334
Mitochondrial dysfunction is a pivotal target for neuroprotection strategies for traumatic brain injury (TBI). However, comprehensive time-course evaluations of mitochondrial dysfunction are lacking in the pre-clinical penetrating TBI (PTBI) model. T
Autor:
Alley E. Ronaldi, Marta Madurska, Philip J. Spreadborough, Lai Yee Leung, Todd E. Rasmussen, Jeanette E. Polcz, John A. Mares, Joseph M. White
Publikováno v:
Journal of Surgical Research. 256:171-179
Background Resuscitative endovascular balloon occlusion of the aorta (REBOA) reduces blood loss and improves hemodynamics. Complete occlusion results in distal ischemia, limiting its use for prolonged care. This study evaluated two next-generation pa
Autor:
Alley E. Ronaldi, Alexis L. Lauria, Jeanette E. Paterson, Alexander J. Kersey, Lai Yee Leung, David M. Burmeister, David G. Baer, Paul W. White, Todd E. Rasmussen, Joseph M. White
Publikováno v:
Shock (Augusta, Ga.). 57(5)
Targeted regional optimization (TRO) describes partial resuscitative endovascular balloon occlusion of the aorta strategy that allows for controlled distal perfusion to balance hemostasis and tissue perfusion. This study characterized hemodynamics at