Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Lai Sum Leoh"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf
Externí odkaz:
https://doaj.org/article/8b4e515bbd214f91a2e4caef799148c5
Autor:
Anamika Basu, Christina K Cajigas-Du Ross, Leslimar Rios-Colon, Melanie Mediavilla-Varela, Tracy R Daniels-Wells, Lai Sum Leoh, Heather Rojas, Hiya Banerjee, Shannalee R Martinez, Stephanny Acevedo-Martinez, Carlos A Casiano
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146549 (2016)
Prostate cancer (PCa) mortality is driven by highly aggressive tumors characterized by metastasis and resistance to therapy, and this aggressiveness is mediated by numerous factors, including activation of stress survival pathways in the pro-inflamma
Externí odkaz:
https://doaj.org/article/178d5abb953b482b89f90f838bdba422
Autor:
Tracy R. Daniels-Wells, Otoniel Martinez-Maza, Miguel Nava, Manuel L. Penichet, Lai Sum Leoh, Pierre V. Candelaria
Publikováno v:
J Immunother
The transferrin receptor 1 (TfR1) is a meaningful target for antibody-based cancer therapy given its overexpression on malignant cells and its central role in cancer pathology. We previously developed a mouse/human chimeric IgG3 targeting human TfR1
Autor:
Dmytro Klymyshyn, Alexander V. Ljubimov, Serguei Bannykh, Rameshwar Patil, Frank B. Furnari, Yongmei L. Chen, Webster K. Cavenee, Vida Falahatian, Manuel L. Penichet, Eggehard Holler, Chirag G. Patil, Arthur Rekechenetskiy, Jeremy Rudnick, Shawn Wagner, Alexander V. Lyubimov, Julia Y. Ljubimova, Adam N. Mamelak, Tao Sun, Vladimir A. Ljubimov, Hui Ding, Tracy R. Daniels-Wells, Keith L. Black, Zachary B. Grodzinski, Lai Sum Leoh, Ekaterina S. Shatalova, Debiao Li, Jethro Hu, Alexandra Chesnokova, Anna Galstyan
Publikováno v:
Cancer research, vol 79, iss 6
There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix, including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359e72469f5b47f68cc313caf0463937
https://escholarship.org/uc/item/6sq4p868
https://escholarship.org/uc/item/6sq4p868
Autor:
Lai Sum Leoh, Pierre V. Candelaria, Otoniel Martinez-Maza, Tracy R. Daniels-Wells, Yoon Kyung Kim, Manuel L. Penichet
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 200, iss 10
The transferrin receptor 1 (TfR1) is an attractive target for Ab-mediated cancer therapy. We previously developed a mouse/human chimeric IgG3 Ab (ch128.1) targeting human TfR1, which exhibits direct in vitro cytotoxicity against certain human maligna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729c094cccdafac55400779c2c2b7d87
https://escholarship.org/uc/item/4xd9c75v
https://escholarship.org/uc/item/4xd9c75v
Autor:
Daniel P. Widney, Tracy R. Daniels-Wells, Lai Sum Leoh, Manuel L. Penichet, Otoniel Martinez-Maza
Publikováno v:
Journal of Immunotherapy. 38:307-310
The transferrin receptor 1 (TfR1), also known as CD71, is a target for antibody-based cancer immunotherapy due to its high expression on the surface of cancer cells and its ability to internalize. We have previously developed a mouse/human chimeric I
Autor:
Kouki Morizono, Manuel L. Penichet, Kathleen M. Kershaw, Irvin S. Y. Chen, Tracy R. Daniels-Wells, Lai Sum Leoh
Publikováno v:
The Journal of Gene Medicine. 16:11-27
Author(s): Leoh, Lai Sum; Morizono, Kouki; Kershaw, Kathleen M; Chen, Irvin SY; Penichet, Manuel L; Daniels-Wells, Tracy R | Abstract: BackgroundWe previously developed an antibody-avidin fusion protein (ch128.1Av) specific for the human transferrin
Autor:
Otoniel Martinez-Maza, Graciel Diamante, Michael A. Erb, Manuel L. Penichet, Tracy R. Daniels-Wells, David Casero, Jose A. Rodriguez, Gustavo Helguera, Matteo Pellegrini, Lai Sum Leoh
Publikováno v:
Toxicology in Vitro. 27:220-231
We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av is also a delivery system and
Autor:
Lai Sum Leoh, Zeger Debyser, Marino De Leon, Valeri Filippov, Leslimar Rios-Colon, Shannalee R. Martinez, Frauke Christ, Jan De Rijck, Maria Filippova, Sandy S. Tungteakkhun, Anamika Basu, Bart van Heertum, Carlos A. Casiano
Publikováno v:
Molecular Cancer Research. 10:378-391
The lens epithelium–derived growth factor p75 (LEDGF/p75) is a transcription coactivator that promotes resistance to oxidative stress- and chemotherapy-induced cell death. LEDGF/p75 is also known as the dense fine speckles autoantigen of 70 kDa (DF
Autor:
Manuel L. Penichet, Tracy R. Daniels-Wells, Lai Sum Leoh, Otoniel Martinez-Maza, Pierre V. Candelaria
Publikováno v:
Cancer Research. 78:5760-5760
The transferrin receptor 1 (TfR1), also identified as CD71, is a type II transmembrane homodimeric protein involved in the cellular uptake of iron and in the regulation of cell growth. TfR1 is a meaningful target for antibody-based cancer immunothera