Výsledky vyhledávání

Supplementary Data 4 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Figures S2, S3 and S4. Morphometric analysis of laminin-411 β1 chain (S2) and cancer stem cell markers (Notch-1, Notch-3, CD133, Nestin, and c-Myc; S3 and S4) on frozen sections of patient brain tumors. The expression of all markers significantly co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7954ae943f08a0594bc3fcdb183822b6
https://doi.org/10.1158/0008-5472.22423184.v1

Zobrazit plný text záznamu

Supplementary Video from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Video schematically shows the mechanism of glioblastoma treatment by laminin-411 inhibiting nanobioconjugate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1bcf1d94d457d8f4402664174692d4
https://doi.org/10.1158/0008-5472.22423166.v1

Zobrazit plný text záznamu

Supplementary Data 5 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Figure S5. Binding of the nanobioconjugates to U87MG studied by flow cytometry is inhibited by human soluble TfR. This shows that the chimeric anti-human TfR antibody as part of nanobioconjugate fully retained its activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3255e723448b91bdefabf1741fac2b
https://doi.org/10.1158/0008-5472.22423181

Zobrazit plný text záznamu

Supplementary Data 8 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Figure S10. Expression of Notch-1 and its ligand Jagged1 is significantly decreased in patient-derived glioblastoma cell lines with laminin-411 disruption by CRISPR/Cas9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cdcf76995919f58fa3d462d85011ad
https://doi.org/10.1158/0008-5472.22423172.v1

Zobrazit plný text záznamu

Supplementary Data 7 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Figures S8 and S9. Quantification of expression of laminin-411 β1 chain, its binding β1 integrin, Notch family members and other stem cell markers after nanobioconjugate treatment. All markers were significantly suppressed in treated tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c025739000157f1340b145f3c28041b
https://doi.org/10.1158/0008-5472.22423175.v1

Zobrazit plný text záznamu

Supplementary Data 1 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Tables S1, S2 and S3, and Figure S1. List of used antibodies (Table S1), and immunohistochemical expression of laminin-411 and laminin-421 in human gliomas of various grades (Tables S2 and S3). Expression of laminin-411 vs. laminin-421 increases with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137908ec50a23363e4def7c22981d42
https://doi.org/10.1158/0008-5472.22423193

Zobrazit plný text záznamu

Supplementary Data 2 from Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Table S4. Physico-chemical characterization of used control and treatment nanobioconjugates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426cffb2ac89cc206a84c7ec1b3c3316
https://doi.org/10.1158/0008-5472.22423190

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání