Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants.

Autor: Le UNP; Graduate Institute of Biological Science and Technology, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan., Chang YJ; The Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung, Taiwan., Lu CH; The Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung, Taiwan; Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Chen Y; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, 402, Taiwan., Su WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan., Chao ST; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan., Baltina LA; Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, Russia., Petrova SF; Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, Russia., Li SR; Department of Laboratory Medicine, China Medical University Hospital, Taichung, 404327, Taiwan., Hung MC; Research Center for Cancer Biology, China Medical University, Taichung, 404327, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, 404327, Taiwan., Lai MMC; Institute of Molecular Biology, Academia Sinica, Taipei, 115201, Taiwan., Baltina LA; Ufa Institute of Chemistry, Ufa Federal Research Center of the Russian Academy of Sciences, Russia. Electronic address: baltina@anrb.ru., Lin CW; Graduate Institute of Biological Science and Technology, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan; The Ph.D. Program of Biotechnology and Biomedical Industry, China Medical University, Taichung, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan; Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.

Publikováno v: Antiviral research [Antiviral Res] 2024 Jul; Vol. 227, pp. 105920. Date of Electronic Publication: 2024 May 29.

Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization.

Autor: Su WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan; International Master's Program of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, 404327, Taiwan; Drug Development Center, China Medical University, Taichung, 404333, Taiwan., Chen ZY; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 404333, Taiwan., Chang YS; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 404333, Taiwan., Jeng KS; Department of Medical Research, China Medical University Hospital, Taichung, 404327, Taiwan., Le UNP; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 404333, Taiwan; Department of Biological Science and Technology, China Medical University, Taichung, 404333, Taiwan., Chou YC; Biomedical Translation Research Center, Academia Sinica, Taipei, 115201, Taiwan., Kuo LL; International Master's Program of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan., Melano I; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan., Jesse; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan., Wang WJ; Department of Biological Science and Technology, China Medical University, Taichung, 404333, Taiwan., Song YC; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan., Li SR; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 404333, Taiwan; Department of Laboratory Medicine, China Medical University Hospital, Taichung, 404327, Taiwan., Hung MC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan; Research Center for Cancer Biology, China Medical University, Taichung, 404327, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung, 404327, Taiwan., Lai MMC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan; Institute of Molecular Biology, Academia Sinica, Taipei, 115201, Taiwan. Electronic address: michlai@gate.sinica.edu.tw., Lin CW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404333, Taiwan; Drug Development Center, China Medical University, Taichung, 404333, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 404333, Taiwan; Department of Biological Science and Technology, China Medical University, Taichung, 404333, Taiwan; Department of Medical Laboratory Science and Biotechnology, Asia University, Wufeng, Taichung, 413305, Taiwan. Electronic address: cwlin@mail.cmu.edu.tw.

Publikováno v: Antiviral research [Antiviral Res] 2023 Dec; Vol. 220, pp. 105744. Date of Electronic Publication: 2023 Nov 07.

Upregulation of galectin-3 in influenza A virus infection promotes viral RNA synthesis through its association with viral PA protein.

Autor: Yang ML; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan.; Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan., Chen YC; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan., Wang CT; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan., Chong HE; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan., Chung NH; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan., Leu CH; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan., Liu FT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lai MMC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan., Ling P; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan., Wu CL; Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan. wumolbio@mail.ncku.edu.tw.; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan. wumolbio@mail.ncku.edu.tw., Shiau AL; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, 1, University Road, Tainan, 701401, Taiwan. alshiau@mail.ncku.edu.tw.; Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan. alshiau@mail.ncku.edu.tw.

Publikováno v: Journal of biomedical science [J Biomed Sci] 2023 Feb 23; Vol. 30 (1), pp. 14. Date of Electronic Publication: 2023 Feb 23.

Retraction for Sung and Lai, 'Murine Retroviral Pseudotype Virus Containing Hepatitis B Virus Large and Small Surface Antigens Confers Specific Tropism for Primary Human Hepatocytes: a Potential Liver-Specific Targeting System'

Autor: Vicky M.-H. Sung, Lai Mmc

Publikováno v: Journal of Virology. 93

We have developed a system for producing murine leukemia virus (MLV) pseudotyped with human hepatitis B virus (HBV) large (L) and small (S) surface antigens (HBsAg) for targeting primary human hepatocytes. Using the MLV(HBV) pseudotype virus containi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe0737e8f75043376e256aba1332385
https://doi.org/10.1128/jvi.00761-19

Ginseng Prong Added to Broiler Diets Reduces Lipid Peroxidation in Refrigerated and Frozen Stored Poultry Meats.

Autor: Lai MMC; Food Nutrition and Health Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Zhang HA; Food Nutrition and Health Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Kitts DD; Food Nutrition and Health Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Jul 01; Vol. 26 (13). Date of Electronic Publication: 2021 Jul 01.