Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lai Kuan Goh"'
Publikováno v:
The Journal of Cell Biology
Four independent mechanisms for uptake of activated EGFR are identified by a combination of receptor mutagenesis and RNA interference approaches.
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR
Endocytosis of the epidermal growth factor receptor (EGFR) is important for the regulation of EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2be342b5426b2e36c156a05537b963
http://europepmc.org/articles/PMC2878939
http://europepmc.org/articles/PMC2878939
Publikováno v:
The Journal of Cell Biology
Processing bodies (P bodies) are conserved mRNA–protein (mRNP) granules that are thought to be cytoplasmic centers for mRNA repression and degradation. However, their specific functions in vivo remain poorly understood. We find that repressed mater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44924c821a7732976c9e2f833b938f17
http://europepmc.org/articles/PMC2500140
http://europepmc.org/articles/PMC2500140
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16904-16909
Ubiquitination of the EGF receptor (EGFR) has been implicated in EGF-induced receptor internalization, lysosomal degradation, and down-regulation. Mutation of EGFR ubiquitination sites identified by mass spectrometry yielded receptor mutants that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e98bc74dc55d7eaa88a3e74a1f5eb3d
https://doi.org/10.1073/pnas.0707416104
https://doi.org/10.1073/pnas.0707416104
Autor:
Lai Kuan Goh, Alexander Sorkin
Publikováno v:
Experimental cell research. 315(4)
This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family. Growth factor binding to EGFR accelerates its internalization through clathrin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692f63162b11e26591bce8da9a08258
https://pubmed.ncbi.nlm.nih.gov/19278030
https://pubmed.ncbi.nlm.nih.gov/19278030
Autor:
Lai Kuan Goh, Alexander Sorkin
Publikováno v:
Cold Spring Harbor Perspectives in Biology. 5:a017459-a017459
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af33f5de505b3693bd8a8c34b0fa1ccd
https://doi.org/10.1101/cshperspect.a017459
https://doi.org/10.1101/cshperspect.a017459
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/23/2007, Vol. 104 Issue 43, p16904-16909, 6p