Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lai Justine Yeun Quai"'
Autor:
Darren Wheeler, Gary Fenton, Bamborough Paul Lindsay, Paul Joseph Cox, Sukanthini Thurairatnam, David J. Aldous, Rajesh Patel, Lai Justine Yeun Quai, Sofia Parveen, Trevor K.P. Harrison, Keith Smith, Clive Mccarthy, Shazia Sadiq, Savita Jagpal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3111-3114
A series of oxindoles demonstrating inhibition of the phosphorylation of biotinylated substrates of Syk and IgE/FceRI triggered basophil cell degranulation has been identified. A study of the SAR around sulfonamide 31 (IC 50 =5 nM, EC 50 =1400 nM) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fdd6c7d6825f3f5bff92438def819f
https://doi.org/10.1016/s0960-894x(03)00658-9
https://doi.org/10.1016/s0960-894x(03)00658-9
Autor:
Lai Justine Yeun Quai, Brian Cox, Martyn Banks, C. Harri.Stylli, Andrew R. Whittington, Philip R. Tiller, Paul W. Smith, John G. Houston
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2821-2824
A library of potentially 1600amide/ester dimers was prepared by reacting 40 acid chlorides with 40 nucleophiles. The whole library was presented for biological screening in 80 sample mixtures, with each of the possible products appearing in a unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a6374416bfe4ba6ddc0462a406e97a4
https://doi.org/10.1016/s0960-894x(01)80820-9
https://doi.org/10.1016/s0960-894x(01)80820-9
Autor:
Christopher Adams, Jane E. Redford, Mark Vine, Keith Smith, Sue King, Lai Justine Yeun Quai, Colin P. Bright, Martyn Foster, Clive Mccarthy, Bamborough Paul Lindsay, John E. Souness, David J. Aldous, Sarah J. Crowe, Sukanthini Thurairatnam, Neil Moorcroft, Kenneth Page, Garry Fenton, Jean-Philippe Letallec, Paul R. Eastwood, Amendola Shelley, Christopher Lawrence, Sudha Rao, Barry M. Wyman, Shazia Sadiq, Trevor K.P. Harrison
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(18)
The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99060b38c706399104bf3c4a544c9587
https://pubmed.ncbi.nlm.nih.gov/12941344
https://pubmed.ncbi.nlm.nih.gov/12941344