Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lai Chun Ong"'
Autor:
Ximei Huang, Sha Huang, Lai Chun Ong, Jason Chu-Shern Lim, Rebecca Joan Mary Hurst, Annals Tatenda Mushunje, Paul Thomas Matsudaira, Jongyoon Han, Peter Rainer Preiser
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virule
Externí odkaz:
https://doaj.org/article/3ed175b2c96241368c208a548f0d23ac
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 2.9MB, In-vitro kinase assay, Histology, Cell proliferation, MANOVA analysis for genomic correlates of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ecb3048e6ff5affcb194a51978b5d1
https://doi.org/10.1158/1535-7163.22497421
https://doi.org/10.1158/1535-7163.22497421
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389efae3908c20bd53e37aa050195e71
https://doi.org/10.1158/1535-7163.c.6535609
https://doi.org/10.1158/1535-7163.c.6535609
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 663K, Ambit kinome tree, Cell proliferation data, Pharmacokinetics, Body weight changes in PC3 efficacy study, Active vessel stain in COLO-205 efficacy study, MV4-11 efficacy model, Drug sensitivity profiling and correlation to mutation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407e7e397fec9712aed4f01696117bc4
https://doi.org/10.1158/1535-7163.22497424
https://doi.org/10.1158/1535-7163.22497424
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
XLS file - 167K, Table 1: Cell line drug sensitivity data for SB2343 and mutations in cancer genes. Table 2: Results from MANOVA analysis of cancer genes as modifiers of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794bb76ff68be2e6a52cec2e5c03efb5
https://doi.org/10.1158/1535-7163.22497418
https://doi.org/10.1158/1535-7163.22497418
Autor:
Yilong Fu, Lai-Chun Ong, Sudhir H Ranganath, Lin Zheng, Irene Kee, Wenbo Zhan, Sidney Yu, Pierce K H Chow, Chi-Hwa Wang
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148123 (2016)
Early diagnosis of low grade glioma has been a challenge to clinicians. Positron Emission Tomography (PET) using 18F-FDG as a radio-tracer has limited utility in this area because of the high background in normal brain tissue. Other radiotracers such
Externí odkaz:
https://doaj.org/article/c7f968ceacb04fb6a7cbdeb1150b77df
A Comparison of Imaging Techniques to Monitor Tumor Growth and Cancer Progression in Living Animals.
Autor:
Puaux, Anne-Laure1 anne-laure.j.puaux@gskbio.com, Lai Chun Ong2, Yi Jin2, Teh, Irvin3, Hong, Michelle1, Chow, Pierce K. H.4,5, Golay, Xavier3, Abastado, Jean-Pierre1
Publikováno v:
International Journal of Molecular Imaging. 2011, p1-12. 12p.
Autor:
Lin Zheng, Lai Chun Ong, Yi Jin, Chongben Zhang, Sidney Yu, Yingke He, Zhen Yan, Mitsuhara Okutsu, Pierce K. H. Chow, Mei Zhang
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 305:E530-E539
Animal studies have shown that autophagy is essential in the process of obesity. Here, we performed daily injection of the autophagy inhibitor chloroquine (CQ) in mice and found that systemic administration of CQ blocks high-fat diet-induced obesity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a24c7651b21e0d3856b40076dd4158d
https://doi.org/10.1152/ajpendo.00640.2012
https://doi.org/10.1152/ajpendo.00640.2012
Autor:
Wenbo Zhan, Lin Zheng, Sudhir H. Ranganath, Yilong Fu, Irene Kee, Pierce K. H. Chow, Lai-Chun Ong, Sidney Yu, Chi-Hwa Wang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 2, p e0148123 (2016)
PLoS ONE, Vol 11, Iss 2, p e0148123 (2016)
Early diagnosis of low grade glioma has been a challenge to clinicians. Positron Emission Tomography (PET) using 18F-FDG as a radio-tracer has limited utility in this area because of the high background in normal brain tissue. Other radiotracers such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbcdf1ac768f62c275150641196f07f
http://hdl.handle.net/10044/1/69145
http://hdl.handle.net/10044/1/69145
Autor:
Lai Chun Ong, Jean-Pierre Abastado, Irvin Teh, Pierce K. H. Chow, Michelle Hong, Yi Jin, Xavier Golay, Anne-Laure Puaux
Publikováno v:
International Journal of Molecular Imaging
Introduction and Purpose. Monitoring solid tumor growth and metastasis in small animals is important for cancer research. Noninvasive techniques make longitudinal studies possible, require fewer animals, and have greater statistical power. Such techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc767f77cb80fe46543c9a67d0dae6d
https://doi.org/10.1155/2011/321538
https://doi.org/10.1155/2011/321538