Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation

Autor: van der Velden, JLJ, Hoffman, SM, Alcorn, JF, Tully, JE, Chapman, DG, Lahue, KG, Guala, AS, Lundblad, LKA, Aliyeva, M, Daphtary, N, Irvin, CG, Janssen-Heininger, YMW

Chronic allergic asthma leads to airway remodeling and subepithelial fibrosis via mechanisms not fully understood. Airway remodeling is amplified by profibrotic mediators, such as transforming growth factor-β1 (TGF-β1), which plays a cardinal role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::f75804b422cabe8139c0e68890e25c6e
https://hdl.handle.net/10453/118816

Analysis of CNS autoimmunity in genetically diverse mice reveals unique phenotypes and mechanisms.

Autor: Nelson EA; Department of Biomedical and Health Sciences, University of Vermont (UVM), Burlington, Vermont, USA., Tyler AL; The Jackson Laboratory, Bar Harbor, Maine, USA., Lakusta-Wong T; Department of Neurological Sciences and., Lahue KG; Department of Biomedical and Health Sciences, University of Vermont (UVM), Burlington, Vermont, USA., Hankes KC; Department of Biomedical and Health Sciences, University of Vermont (UVM), Burlington, Vermont, USA., Teuscher C; Department of Medicine, UVM, Larner College of Medicine, Burlington, Vermont, USA., Lynch RM; Department of Genetics, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA., Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill (UNC), Chapel Hill, North Carolina, USA., Mahoney JM; The Jackson Laboratory, Bar Harbor, Maine, USA.; Department of Neurological Sciences and., Krementsov DN; Department of Biomedical and Health Sciences, University of Vermont (UVM), Burlington, Vermont, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Nov 08; Vol. 9 (21). Date of Electronic Publication: 2024 Nov 08.

LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.

Autor: Sabikunnahar B; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Caldwell S; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Varnum S; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Hogan T; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Lahue KG; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA., Rathkolb B; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University München, Munich, Germany., Gerlini R; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Dragano NRV; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Aguilar-Pimentel A; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Irmler M; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Sanz-Moreno A; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., da Silva-Buttkus P; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Beckers J; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; TUM School of Life Sciences, Technische Universität München, Freising, Germany., Wolf E; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University München, Munich, Germany., Gailus-Durner V; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Fuchs H; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany., Hrabe de Angelis M; Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum München, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; TUM School of Life Sciences, Technische Universität München, Freising, Germany., Ather JL; Department of Medicine, University of Vermont, Burlington, Vermont, USA., Poynter ME; Department of Medicine, University of Vermont, Burlington, Vermont, USA., Krementsov DN; Department of Biomedical and Health Sciences, University of Vermont, Burlington, Vermont, USA.

Publikováno v: Physiological reports [Physiol Rep] 2024 Jan; Vol. 12 (1), pp. e15901.

Host Genetic Variation Has a Profound Impact on Immune Responses Mediating Control of Viral Load in Chronic Gammaherpesvirus Infection.

Autor: Holt EA; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT., Waytashek CM; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT., Sessions KJ; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT., Asarian L; Department of Medicine, Vermont Center for Immunology and Infectious Diseases, Larner College of Medicine, University of Vermont, Burlington, VT., Lahue KG; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT., Usherwood EJ; Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth College, Lebanon, NH., Teuscher C; Department of Medicine, Vermont Center for Immunology and Infectious Diseases, Larner College of Medicine, University of Vermont, Burlington, VT., Krementsov DN; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2023 Nov 15; Vol. 211 (10), pp. 1526-1539.

Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity.

Autor: Montgomery TL; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05401, USA., Eckstrom K; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, 05401, USA., Lile KH; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05401, USA., Caldwell S; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05401, USA., Heney ER; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05401, USA., Lahue KG; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05401, USA., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado, Aurora, CO, 80045, USA., Wargo MJ; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT, 05401, USA., Krementsov DN; Department of Biomedical and Health Sciences, University of Vermont, Burlington, VT, 05401, USA. dimitry.krementsov@uvm.edu.

Publikováno v: Microbiome [Microbiome] 2022 Nov 23; Vol. 10 (1), pp. 198. Date of Electronic Publication: 2022 Nov 23.