Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lahiru N. Wimalasena"'
Autor:
Brianna M. Karpowicz, Yahia H. Ali, Lahiru N. Wimalasena, Andrew R. Sedler, Mohammad Reza Keshtkaran, Kevin Bodkin, Xuan Ma, Lee E. Miller, Chethan Pandarinath
Intracortical brain-computer interfaces (iBCIs) restore motor function to people with paralysis by translating brain activity into control signals for external devices. In current iBCIs, instabilities at the neural interface result in a degradation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1da26a6044f4eda03db5afcb9b8666bd
https://doi.org/10.1101/2022.04.06.487388
https://doi.org/10.1101/2022.04.06.487388
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception
Autor:
Yoshie Narui, Marcos Sotomayor, Elakkiya Tamilselvan, Pedro De-la-Torre, Carissa F. Klanseck, Conghui Chen, Deepanshu Choudhary, Raul Araya-Secchi, Lahiru N. Wimalasena, Brandon L. Neel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Choudhary, D, Narui, Y, Neel, B L, Wimalasena, L N, Klanseck, C F, De-la-Torre, P, Chen, C, Araya-Secchi, R, Tamilselvan, E & Sotomayor, M 2020, ' Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 40, pp. 24837-24848 . https://doi.org/10.1073/pnas.1920444117
Choudhary, D, Narui, Y, Neel, B L, Wimalasena, L N, Klanseck, C F, De-la-Torre, P, Chen, C, Araya-Secchi, R, Tamilselvan, E & Sotomayor, M 2020, ' Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 40, pp. 24837-24848 . https://doi.org/10.1073/pnas.1920444117
Significance When sound vibrations reach the inner ear, fine protein filaments called “tip links” stretch and open cochlear hair-cell mechanosensitive channels that trigger sensory perception. Similarly, vestibular hair cells use tip links to sen
Autor:
Lahiru N Wimalasena, Jonas F Braun, Mohammad Reza Keshtkaran, David Hofmann, Juan Álvaro Gallego, Cristiano Alessandro, Matthew C Tresch, Lee E Miller, Chethan Pandarinath
Publikováno v:
J Neural Eng
Objective. To study the neural control of movement, it is often necessary to estimate how muscles are activated across a variety of behavioral conditions. One approach is to try extracting the underlying neural command signal to muscles by applying l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8de4ae0fa74bbb13dad7e02ffac0433
https://doi.org/10.1101/2021.12.01.470827
https://doi.org/10.1101/2021.12.01.470827
Publikováno v:
Nature Biomedical Engineering. 4:665-667
In the presence of recording instabilities, the performance of brain–computer interfaces can be robustly maintained by exploiting ‘hidden’ structures underlying neural activity.
Publikováno v:
Nat Biomed Eng
The instability of neural recordings can render clinical brain-computer interfaces (BCIs) uncontrollable. Here, we show that the alignment of low-dimensional neural manifolds (low-dimensional spaces that describe specific correlation patterns between
Structural determinants of protocadherin-15 elasticity and function in inner-ear mechanotransduction
Autor:
Lahiru N. Wimalasena, Elakkiya Tamilselvan, Carissa F. Klanseck, Conghui Chen, Marcos Sotomayor, Brandon L. Neel, Yoshie Narui, Pedro De-la-Torre, Deepanshu Choudhary, Raul Araya-Secchi
Protocadherin-15 (PCDH15), an atypical member of the cadherin superfamily, is essential for vertebrate hearing and its dysfunction has been associated with deafness and progressive blindness. The PCDH15 ectodomain, made of eleven extracellular cadher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8914c9e0ec9677538b428598ce8ff99
https://doi.org/10.1101/695502
https://doi.org/10.1101/695502
Publikováno v:
Biophysical Journal. 118:276a
Autor:
Pedro De-la-Torre, Carissa F. Klanseck, Deepanshu Choudhary, Jeffrey M. Lotthammer, Conghui Chen, Elakkiya Tamilselvan, Yoshie Narui, Sanket Walujkar, Joseph C. Sudar, Collin R. Nisler, Marcos Sotomayor, Raul Araya-Secchi, Brandon L. Neel, Lahiru N. Wimalasena
Publikováno v:
Biophysical Journal. 118:13a
Autor:
Kiyoto Kurima, Bifeng Pan, Sanket Walujkar, Carl Nist-Lund, Xiao-Ping Liu, Nurunisa Akyuz, Lahiru N. Wimalasena, Walrati Limapichat, Bruce Derfler, Marcos Sotomayor, David P. Corey, Jeffrey R. Holt, Yukako Asai, Bence György
Publikováno v:
Neuron. 99(4)
Summary The proteins that form the permeation pathway of mechanosensory transduction channels in inner-ear hair cells have not been definitively identified. Genetic, anatomical, and physiological evidence support a role for transmembrane channel-like
Autor:
Deepanshu Choudhary, Yoshie Narui, Conghui Chen, Carissa F. Klanseck, Brandon L. Neel, Marcos Sotomayor, Pedro De-la-Torre, Lahiru N. Wimalasena, Elakkiya Tamilselvan, Raul Araya-Secchi
Publikováno v:
Biophysical Journal. 116:427a