Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Lahari Kolli"'
1
Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways
Autor: Siva SVP Sakamuri, Venkata N Sure, Lahari Kolli, Wesley R Evans, Jared A Sperling, Gregory J Bix, Xiaoying Wang, Dmitriy N Atochin, Walter L Murfee, Ricardo Mostany, Prasad VG Katakam
Publikováno v: J Cereb Blood Flow Metab
Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The goal of our study is to characterize the impact of aging on brain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a3cd3c4663c1f8344099494ee62391
https://doi.org/10.1177/0271678x211069266
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3
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells
Autor: Siva S. V. P. Sakamuri, Venkata N. Sure, Lahari Kolli, Ning Liu, Wesley R. Evans, Jared A. Sperling, David W. Busija, Xiaoying Wang, Sarah H. Lindsey, Walter L. Murfee, Ricardo Mostany, Prasad V. G. Katakam
Publikováno v: GeroScience
Alterations of mitochondrial and glycolytic energy pathways related to aging could contribute to cerebrovascular dysfunction. We studied the impact of aging on energetics of primary human brain microvascular endothelial cells (HBMECs) by comparing th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446ede1af773c39096646ac6b5a3609d
https://europepmc.org/articles/PMC9616994/
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4
Abstract TP248: Nos Inhibitor Is An Effective Adjuvant To Reperfusion Therapy In Ischemic Stroke In Mice
Autor: William P Wisen, Wesley R Evans, Venkata N Sure, Siva S Sakamuri, Lahari Kolli, Aaron L Albuck, Ricardo Mostany, Prasad V Katakam
Publikováno v: Stroke. 53
Background: Inhibition nitric oxide synthase (NOS) has been shown to paradoxically protect against ischemic brain injury by an unknown mechanism. Recently, we found that NOS inhibitor, N (gamma)-nitro-L-arginine methyl ester (L-NAME), protects primar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acecbf42a424ab6eaa98e6eb7157723a
https://doi.org/10.1161/str.53.suppl_1.tp248
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5
Abstract WP245: Sex-dependent Regulation Of Mitochondrial Respiratory Function In Mouse Brain Microvessels By Peroxynitrite Decomposition Catalyst
Autor: Siva S Sakamuri, Lahari Kolli, William P Wisen, Venkata N Sure, Wesley R Evans, Sarah H Lindsey, Ricardo Mostany, Prasad V Katakam
Publikováno v: Stroke. 53
Background: Peroxynitrite (PN) is a strong oxidizing and nitrating molecule. PN is a potent inhibitor of mitochondrial respiration and mediates the ischemia-reperfusion injury following stroke. In isolated mouse brain mitochondria, we observed that P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97ffc47f84d8db1e3108a582bceaf6ed
https://doi.org/10.1161/str.53.suppl_1.wp245
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7
Peroxynitrite decomposition catalyst enhances respiratory function in isolated brain mitochondria
Autor: Jared A. Sperling, Ricardo Mostany, Wesley R. Evans, Aaron L. Albuck, Venkata N. Sure, Lahari Kolli, Prasad V. G. Katakam, Siva S.V.P. Sakamuri
Publikováno v: Am J Physiol Heart Circ Physiol
Peroxynitrite (PN), generated from the reaction of nitric oxide (NO) and superoxide, is implicated in the pathogenesis of ischemic and neurodegenerative brain injuries. Mitochondria produce NO from mitochondrial NO synthases and superoxide by the ele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26df3dac4e4b1851d07035589bd16056
https://pubmed.ncbi.nlm.nih.gov/33164581
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