Eptinezumab treatment initiated during a migraine attack is associated with meaningful improvement in patient-reported outcome measures: secondary results from the randomized controlled RELIEF study

Autor: Peter McAllister, Paul K. Winner, Jessica Ailani, Dawn C. Buse, Richard B. Lipton, George Chakhava, Mette Krog Josiassen, Annika Lindsten, Lahar Mehta, Anders Ettrup, Roger Cady

Publikováno v: The Journal of Headache and Pain, Vol 23, Iss 1, Pp 1-10 (2022)

Abstract Background Demonstrating therapeutic value from the patient perspective is important in patient-centered migraine management. The objective of this study was to investigate the impact of eptinezumab, a preventive migraine treatment, on patie

Externí odkaz: https://doaj.org/article/01048f33773d406b8c9421698d8a7692

Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review

Autor: Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbanc

Externí odkaz: https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75

Impact of Baseline Characteristics on the Efficacy and Safety of Eptinezumab in Patients With Migraine: Subgroup Analyses of PROMISE-1 and PROMISE-2

Autor: Vincent, Martin, A Jim, Nagy, Marina, Janelidze, Gvantsa, Giorgadze, Joe, Hirman, Roger, Cady, Lahar, Mehta, Dawn C, Buse

Publikováno v: Clinical Therapeutics. 44:389-402

In the PROMISE-1 (Prevention of Migraine via Intravenous ALD403 Safety and Efficacy-1) and PROMISE-2 (Prevention of Migraine via Intravenous ALD403 Safety and Efficacy-2) clinical trials, eptinezumab 100 mg and 300 mg met the primary efficacy end poi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232bc630370f050b241cb1014802d8b1
https://doi.org/10.1016/j.clinthera.2022.01.006

Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial

Autor: Roger Cady, Paul Winner, Peter McAllister, George Chakhava, Annika Lindsten, Anders Ettrup, Lahar Mehta, Mette Krog Josiassen, Jessica Ailani

Publikováno v: JAMA. 325(23)

Intravenous eptinezumab, an anti-calcitonin gene-related peptide antibody, is approved for migraine prevention in adults. It has established onset of preventive efficacy on day 1 after infusion.To evaluate the efficacy of and adverse events related t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f17f8da073c63fcb115eb9e336037ab
https://pubmed.ncbi.nlm.nih.gov/34129013

Additional file 1 of Safety and tolerability of eptinezumab in patients with migraine: a pooled analysis of 5 clinical trials

Autor: Smith, Timothy R., Egilius L. H. Spierings, Cady, Roger, Hirman, Joe, Schaeffler, Barbara, Shen, Vivienne, Sperling, Bjørn, Brevig, Thomas, Josiassen, Mette Krog, Brunner, Elizabeth, Honeywell, Loan, Lahar Mehta

Additional file 1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f82bf699e23bf0535807624ee91cad