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Cyclosporin A toxicity on endothelial cells differentiated from induced pluripotent stem cells: Assembling an adverse outcome pathway.

Autor: Mazidi Z; Evercyte GmbH, Leberstrasse 20, 1110 Vienna, Austria; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Muthgasse 18, 1190 Vienna, Austria., Wieser M; Evercyte GmbH, Leberstrasse 20, 1110 Vienna, Austria., Spinu N; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK., Weidinger A; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstrasse 13, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Kozlov AV; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstrasse 13, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Vukovic K; Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche 'Mario Negri'-IRCCS, Via Mario Negri 2, 20156 Milano, Italy., Wellens S; University of Artois, UR2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France., Murphy C; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081HZ Amsterdam, the Netherlands., Singh P; Edelweiss Connect GmbH, Technology Park Basel, Hochbergerstrasse 60C, 4057 Basel, Switzerland; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland., Lagares LM; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, 1000 Ljubljana, Slovenia., Bobbili MR; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Muthgasse 18, 1190 Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstrasse 13, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Liendl L; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Muthgasse 18, 1190 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Schosserer M; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Muthgasse 18, 1190 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Diendorfer A; TAmiRNA GmbH, Leberstrasse 20, Vienna, Austria., Bettelheim B; Department of Obstetrics and Gynecology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Eilenberg W; Department of General Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria., Exner T; Seven Past Nine d.o.o., Hribljane 10, 1380 Cerknica, Slovenia., Culot M; University of Artois, UR2465, Laboratoire de la Barrière Hémato-Encéphalique (LBHE), Faculté des sciences Jean Perrin, Rue Jean Souvraz SP18, F-62300 Lens, France., Jennings P; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081HZ Amsterdam, the Netherlands., Wilmes A; Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081HZ Amsterdam, the Netherlands., Novic M; Theory Department, Laboratory for Cheminformatics, National Institute of Chemistry, 1000 Ljubljana, Slovenia., Benfenati E; Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche 'Mario Negri'-IRCCS, Via Mario Negri 2, 20156 Milano, Italy., Grillari-Voglauer R; Evercyte GmbH, Leberstrasse 20, 1110 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria., Grillari J; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Muthgasse 18, 1190 Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Donaueschingenstrasse 13, 1200 Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria. Electronic address: johannes.grllari@lbg.ac.at.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2024 Nov 15; Vol. 103, pp. 105954. Date of Electronic Publication: 2024 Nov 15.