Zobrazeno 1 - 10
of 7 819
pro vyhledávání: '"Lafrance, A"'
Publikováno v:
Journal of Eating Disorders, Vol 12, Iss 1, Pp 1-6 (2024)
Abstract Psychedelic medicine is currently being evaluated for numerous mental health indications, and there is significant interest in applying these models of care to eating disorders (EDs) given the limited efficacy of available treatment models,
Externí odkaz:
https://doaj.org/article/1db2d2a1475441c6a7539b6c76ab9a03
Autor:
Martinkus, Karolis, Ludwiczak, Jan, Cho, Kyunghyun, Liang, Wei-Ching, Lafrance-Vanasse, Julien, Hotzel, Isidro, Rajpal, Arvind, Wu, Yan, Bonneau, Richard, Gligorijevic, Vladimir, Loukas, Andreas
We introduce AbDiffuser, an equivariant and physics-informed diffusion model for the joint generation of antibody 3D structures and sequences. AbDiffuser is built on top of a new representation of protein structure, relies on a novel architecture for
Externí odkaz:
http://arxiv.org/abs/2308.05027
Autor:
Frey, Nathan C., Berenberg, Daniel, Zadorozhny, Karina, Kleinhenz, Joseph, Lafrance-Vanasse, Julien, Hotzel, Isidro, Wu, Yan, Ra, Stephen, Bonneau, Richard, Cho, Kyunghyun, Loukas, Andreas, Gligorijevic, Vladimir, Saremi, Saeed
We resolve difficulties in training and sampling from a discrete generative model by learning a smoothed energy function, sampling from the smoothed data manifold with Langevin Markov chain Monte Carlo (MCMC), and projecting back to the true data man
Externí odkaz:
http://arxiv.org/abs/2306.12360
Autor:
Gruver, Nate, Stanton, Samuel, Frey, Nathan C., Rudner, Tim G. J., Hotzel, Isidro, Lafrance-Vanasse, Julien, Rajpal, Arvind, Cho, Kyunghyun, Wilson, Andrew Gordon
Publikováno v:
Advances in Neural Information Processing Systems 36, December 10-16, 2023
A popular approach to protein design is to combine a generative model with a discriminative model for conditional sampling. The generative model samples plausible sequences while the discriminative model guides a search for sequences with high fitnes
Externí odkaz:
http://arxiv.org/abs/2305.20009
Autor:
Jane B. Allendorfer, Rodolphe Nenert, Adam M. Goodman, Pranav Kakulamarri, Stephen Correia, Noah S. Philip, W. Curt LaFrance Jr, Jerzy P. Szaflarski
Publikováno v:
Epilepsia Open, Vol 9, Iss 3, Pp 969-980 (2024)
Abstract Objective Traumatic brain injury (TBI) often precedes the onset of epileptic (ES) or psychogenic nonepileptic seizures (PNES) with depression being a common comorbidity. The relationship between depression severity and quality of life (QOL)
Externí odkaz:
https://doaj.org/article/a6cc2cd8ab614bccb437fe89bd94199a
Autor:
Raphaël Vincent, Maxime Charron, Simon Lafrance, Audrey-Anne Cormier, Dahlia Kairy, François Desmeules
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e52964 (2024)
BackgroundAccess to care is a major challenge for patients with musculoskeletal disorders (MSKDs). Telemedicine is one of the solutions to improve access to care. However, initial remote diagnosis of MSKDs involves some challenges, such as the imposs
Externí odkaz:
https://doaj.org/article/f08e46d91e5242329df29423a4d987eb
Autor:
Lafrance, Adele1 (AUTHOR) adele@dradelelafrance.com, Spriggs, Meg J.2 (AUTHOR), Gukasyan, Natalie3 (AUTHOR), Peck, Stephanie Knatz4 (AUTHOR)
Publikováno v:
Journal of Eating Disorders. 9/30/2024, Vol. 12 Issue 1, p1-6. 6p.
A Pareto-optimal compositional energy-based model for sampling and optimization of protein sequences
Autor:
Tagasovska, Nataša, Frey, Nathan C., Loukas, Andreas, Hötzel, Isidro, Lafrance-Vanasse, Julien, Kelly, Ryan Lewis, Wu, Yan, Rajpal, Arvind, Bonneau, Richard, Cho, Kyunghyun, Ra, Stephen, Gligorijević, Vladimir
Deep generative models have emerged as a popular machine learning-based approach for inverse design problems in the life sciences. However, these problems often require sampling new designs that satisfy multiple properties of interest in addition to
Externí odkaz:
http://arxiv.org/abs/2210.10838
Autor:
Heather R. Kates, Brian C. O’Meara, Raphael LaFrance, Gregory W. Stull, Euan K. James, Shui-Yin Liu, Qin Tian, Ting-Shuang Yi, Daniel Conde, Matias Kirst, Jean-Michel Ané, Douglas E. Soltis, Robert P. Guralnick, Pamela S. Soltis, Ryan A. Folk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Root nodule symbiosis (RNS) is a complex trait that enables plants to access atmospheric nitrogen converted into usable forms through a mutualistic relationship with soil bacteria. Pinpointing the evolutionary origins of RNS is critical for
Externí odkaz:
https://doaj.org/article/309139ba92a84ba99fab71a95dc40859
Autor:
Moana Gelu-Simeon, Marie-Josée Lafrance, Leah Michineau, Eric Saillard, Jean Pierre Thomé, Claude Emond, Michel Samson, Luc Multigner
Publikováno v:
Environmental Health, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Background and Aims Chlordecone is a persistent organochlorinated insecticide, extensively used in the French West Indies and has been contaminating the population for more than thirty years. Its potentiation effect on hepatotoxic agents has
Externí odkaz:
https://doaj.org/article/b945bc8718214513b54b987e4d66ef1d