Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl-homeostasis

Autor: Ferrini, F, Trang, T, Mattioli, TAM, Laffray, S, Del'Guidice, T, Lorenzo, LE, Castonguay, A, Doyon, N, Zhang, W, Godin, AG, Mohr, D, Beggs, S, Vandal, K, Beaulieu, JM, Cahill, CM, Salter, MW, De Koninck, Y

Publikováno v: Ferrini, F; Trang, T; Mattioli, TAM; Laffray, S; Del'Guidice, T; Lorenzo, LE; et al.(2013). Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl-homeostasis. Nature Neuroscience, 16(2), 183-192. doi: 10.1038/nn.3295. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7cb5f8pv

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K+-Cl-co-trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::88b5109ec96f36ddc4552e30c9ac2579
http://www.escholarship.org/uc/item/7cb5f8pv

Contribution of T-type calcium channel isoforms to cold and mechanical sensitivity in naïve and oxaliplatin-treated mice of both sexes.

Autor: Antunes FTT; Department of Clinical Neurosciences, Cumming School of Medicine, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada., Gandini MA; Department of Clinical Neurosciences, Cumming School of Medicine, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada., Gadotti VM; Department of Clinical Neurosciences, Cumming School of Medicine, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.; School of Health Sciences, Postgraduate Program in Pharmaceutical Sciences, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil., Quintão NLM; School of Health Sciences, Postgraduate Program in Pharmaceutical Sciences, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil., Santin JR; School of Health Sciences, Postgraduate Program in Pharmaceutical Sciences, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil., Souza IA; Department of Clinical Neurosciences, Cumming School of Medicine, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada., David LS; Carleton University, Ottawa, Canada., Snutch TP; Michael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada., Hildebrand M; Carleton University, Ottawa, Canada., Zamponi GW; Department of Clinical Neurosciences, Cumming School of Medicine, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Dec; Vol. 181 (24), pp. 5062-5078. Date of Electronic Publication: 2024 Sep 19.

Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons.

Autor: Candelas M; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Reynders A; Aix-Marseille-Université, CNRS, Institut de Biologie du Développement de, Marseille, France., Arango-Lievano M; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Neumayer C; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Fruquière A; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Demes E; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Hamid J; Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada., Lemmers C; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Plateforme de Vectorologie, Biocampus Montpellier, CNRS UMS 3426, INSERM US009, Montpellier, France., Bernat C; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Plateforme de Vectorologie, Biocampus Montpellier, CNRS UMS 3426, INSERM US009, Montpellier, France., Monteil A; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France.; Plateforme de Vectorologie, Biocampus Montpellier, CNRS UMS 3426, INSERM US009, Montpellier, France., Compan V; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Laffray S; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France.; Inserm U-1191, Montpellier, France.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France.; Université Montpellier, Montpellier, France., Inquimbert P; CNRS, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France., Le Feuvre Y; UMR 5297, Interdisciplinary Institute for Neuroscience, Bordeaux, France., Zamponi GW; Department of Physiology and Pharmacology, University of Calgary, Calgary, Canada., Moqrich A; Aix-Marseille-Université, CNRS, Institut de Biologie du Développement de, Marseille, France., Bourinet E; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France. emmanuel.bourinet@igf.cnrs.fr.; Inserm U-1191, Montpellier, France. emmanuel.bourinet@igf.cnrs.fr.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France. emmanuel.bourinet@igf.cnrs.fr.; Université Montpellier, Montpellier, France. emmanuel.bourinet@igf.cnrs.fr., Méry PF; Laboratories of Excellence - Ion Channel Science and Therapeutics, Montpellier, France. pierre-francois.mery@igf.cnrs.fr.; Inserm U-1191, Montpellier, France. pierre-francois.mery@igf.cnrs.fr.; CNRS UMR 5203, Institut de Génomique Fonctionnelle, Montpellier, France. pierre-francois.mery@igf.cnrs.fr.; Université Montpellier, Montpellier, France. pierre-francois.mery@igf.cnrs.fr.

Publikováno v: Scientific reports [Sci Rep] 2019 Feb 28; Vol. 9 (1), pp. 3112. Date of Electronic Publication: 2019 Feb 28.

Interleukin-22 receptor 1-mediated stimulation of T-type Ca²⁺ channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway.

Autor: Cai, Hua¹ (AUTHOR), Chen, Siyu^1,2 (AUTHOR), Sun, Yufang^2,3 (AUTHOR), Zheng, Tingting¹ (AUTHOR), Liu, Yulu¹ (AUTHOR), Tao, Jin^2,3,4 (AUTHOR) taoj@suda.edu.cn, Zhang, Yuan^1,3,4 (AUTHOR) yuanzhang@suda.edu.cn

Publikováno v: Cell Communication & Signaling. 6/3/2024, Vol. 22 Issue 1, p1-16. 16p.

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