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Autor:
Ramani T; Pre-Clinical Development, PTC Therapeutics, Warren, NJ, USA., Wange RL; US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD, USA., Manetz TS; Clinical Pharmacology & Safety Sciences, Respiratory & Immunology, Neuroscience, Vaccines & Immune Therapies Safety, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Kruzich PJ; Pre-Clinical Development, PTC Therapeutics, Warren, NJ, USA., Laffan SB; Translational Safety & Bioanalytical Sciences, Amgen, Thousand Oaks, CA, USA., Compton DR; Akkeri, Inc., Annandale, NJ, USA.
Publikováno v:
International journal of toxicology [Int J Toxicol] 2024 Sep-Oct; Vol. 43 (5), pp. 435-455. Date of Electronic Publication: 2024 Jul 20.
Autor:
Fishman C; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Caverly Rae JM; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Posobiec LM; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Laffan SB; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Lerman SA; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Pearson N; Medicinal Chemistry, GSK Research and Development, Collegeville, Pennsylvania, USA., Janmohamed S; Clinical Sciences, GSK Research and Development, Brentford, Middlesex, United Kingdom., Dumont E; Clinical Sciences, GSK Research and Development, Collegeville, Pennsylvania, USA., Nunn-Floyd D; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA., Stanislaus DJ; Nonclinical Safety, GSK Research and Development, Collegeville, Pennsylvania, USA.
Publikováno v:
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Nov 15; Vol. 66 (11), pp. e0048322. Date of Electronic Publication: 2022 Oct 18.
Autor:
Posobiec LM; In Vivo/In Vitro Translation, Nonclinical Safety, GlaxoSmithKline, Collegeville, Pennsylvania, USA., Laffan SB; In Vivo/In Vitro Translation, Nonclinical Safety, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Publikováno v:
Birth defects research [Birth Defects Res] 2021 Mar 15; Vol. 113 (5), pp. 409-426. Date of Electronic Publication: 2020 Dec 14.
Autor:
Cadilla R; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Deaton DN; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA. Electronic address: david.n.deaton@gsk.com., Do Y; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Elkins PA; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Ennulat D; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Guss JH; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Holt J; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Jeune MR; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., King AG; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Klapwijk JC; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Kramer HF; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Kramer NJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Laffan SB; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Masuria PI; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., McDougal AV; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Mortenson PN; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK., Musetti C; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Peckham GE; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Pietrak BL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Poole C; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Price DJ; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Rendina AR; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Sati G; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Saxty G; Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK., Shearer BG; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Shewchuk LM; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Sneddon HF; GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK., Stewart EL; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Stuart JD; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Thomas DN; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Thomson SA; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Ward P; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA., Wilson JW; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Xu T; GlaxoSmithKline, 5 Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA., Youngman MA; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Dec 01; Vol. 28 (23), pp. 115791. Date of Electronic Publication: 2020 Oct 03.
Autor:
Laffan SB; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America., Thomson AS; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., Mai S; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., Fishman C; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America., Kambara T; Pathology, IVIVT, R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America., Nistala K; Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, United Kingdom., Raymond JT; Charles River Laboratories, Inc., Frederick, Maryland, United States of America., Chen S; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., Ramani T; Envigo CRS, Inc., Princeton, New Jersey, United States of America., Pageon L; Envigo CRS, Inc., Princeton, New Jersey, United States of America., Polsky R; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., Watkins M; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America., Ottolangui G; Biopharm Molecular Discovery, R&D Platform Technology and Science, GlaxoSmithKline, Stevenage, United Kingdom., White JR; Biopharm Analytical Science, R&D Platform Technology and Science, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America., Maier C; In vitro In vivo Translation (IVIVT), R&D, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America., Herdman M; Clinical Pharmacology and Experimental Medicine, GlaxoSmithKline, Stevenage, United Kingdom., Bouma G; Adaptive Immunity Research Unit, GlaxoSmithKline, Stevenage, United Kingdom.; Clinical Pharmacology and Experimental Medicine, GlaxoSmithKline, Stevenage, United Kingdom.
Publikováno v:
PloS one [PLoS One] 2020 Apr 23; Vol. 15 (4), pp. e0231655. Date of Electronic Publication: 2020 Apr 23 (Print Publication: 2020).
Autor:
Stanislaus DJ; Reproductive Toxicology, In Vitro/In Vivo Translation, GlaxoSmithKline, Upper Providence, Pennsylvania., Posobiec LM; Reproductive Toxicology, In Vitro/In Vivo Translation, GlaxoSmithKline, Upper Providence, Pennsylvania., Laffan SB; Reproductive Toxicology, In Vitro/In Vivo Translation, GlaxoSmithKline, Upper Providence, Pennsylvania., Solomon HM; Reproductive Toxicology, In Vitro/In Vivo Translation, GlaxoSmithKline, Upper Providence, Pennsylvania., Ziejewski MK; Reproductive Toxicology, In Vitro/In Vivo Translation, GlaxoSmithKline, Upper Providence, Pennsylvania., Romach EH; Non-Clinical Safety, Research & Development, Viiv Healthcare, Research Triangle Park, North Carolina.
Publikováno v:
Birth defects research [Birth Defects Res] 2020 Feb 01; Vol. 112 (3), pp. 245-261. Date of Electronic Publication: 2019 Dec 20.
Autor:
Laffan SB; GlaxoSmithKline Research & Development, King of Prussia, Pennsylvania., Posobiec LM; GlaxoSmithKline Research & Development, King of Prussia, Pennsylvania., Uhl JE; GlaxoSmithKline Research & Development, King of Prussia, Pennsylvania., Vidal JD; MPI Research, Mattawan, Michigan.
Publikováno v:
Birth defects research [Birth Defects Res] 2018 Feb 15; Vol. 110 (3), pp. 163-189. Date of Electronic Publication: 2017 Dec 15.
Autor:
Theunissen PT; a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.; b Medicines Evaluation Board , Utrecht , The Netherlands.; c Innovative Testing in Life Sciences and Chemistry , University of Applied Sciences Utrecht (HU) , Utrecht , The Netherlands., Beken S; d Federal Agency for Medicines and Health Products , Brussels , Belgium., Beyer B; e Sanofi U.S. Inc , Bridgewater , NJ , USA., Breslin WJ; f Lilly Research Laboratories, Lilly Corporate Center , Indianapolis , IN , USA., Cappon GD; g Pfizer Worldwide Research & Development , Groton , CT , USA., Chen CL; h ILSI-Health and Environmental Sciences Institute , Washington , DC , USA., Chmielewski G; i Covance Laboratories Inc , Greenfield , IN , USA., de Schaepdrijver L; j Preclinical Development & Safety , Beerse , Belgium., Enright B; k AbbVie Inc , North Chicago , IL , USA., Foreman JE; l ExxonMobil Biomedical Sciences, Inc , Annandale , NJ , USA., Harrouk W; m US Food & Drug Administration , Silver Spring , MD , USA., Hew KW; n Takeda Pharmaceutical Company , Deerfield , IL , USA., Hoberman AM; o Preclinical Services , Charles-River Laboratories , Horsham , PA , USA., Y Hui J; p Celgene Corporation , Summit , NJ , USA., Knudsen TB; q US Environmental Protection Agency, National Center for Computational Toxicology , Research Triangle Park , NC , USA., Laffan SB; r Safety Assessment , GlaxoSmithKline , King of Prussia , PA , USA., Makris SL; s National Center for Environmental Assessment, US Environmental Protection Agency , Washington , DC , USA., Martin M; q US Environmental Protection Agency, National Center for Computational Toxicology , Research Triangle Park , NC , USA., McNerney ME; t Drug Safety Evaluation , Bristol-Myers Squibb , New Brunswick , NJ , USA., Siezen CL; b Medicines Evaluation Board , Utrecht , The Netherlands., Stanislaus DJ; r Safety Assessment , GlaxoSmithKline , King of Prussia , PA , USA., Stewart J; u Drug Safety & Metabolism , AstraZeneca , Macclesfield , UK., Thompson KE; t Drug Safety Evaluation , Bristol-Myers Squibb , New Brunswick , NJ , USA., Tornesi B; k AbbVie Inc , North Chicago , IL , USA., Van der Laan JW; a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.; b Medicines Evaluation Board , Utrecht , The Netherlands., Weinbauer GF; v Covance Preclinical Services GmbH , Muenster , Germany., Wood S; w Merck Research Laboratories , Upper Gwynedd , PA , USA., Piersma AH; a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.; x Faculty of Veterinary Sciences , Institute for Risk Assessment Sciences, Utrecht University , Utrecht , The Netherlands.
Publikováno v:
Critical reviews in toxicology [Crit Rev Toxicol] 2017 May; Vol. 47 (5), pp. 402-414. Date of Electronic Publication: 2016 Oct 21.
Autor:
Theunissen PT; a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.; b Medicines Evaluation Board , Utrecht , The Netherlands.; c Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences Utrecht (HU) , Utrecht , The Netherlands., Beken S; d Federal Agency for Medicines and Health Products , Brussels , Belgium., Beyer BK; e Sanofi U.S. Inc. Bridgewater , NJ , USA., Breslin WJ; f Lilly Research Laboratories , Lilly Corporate Center , Indianapolis , IN , USA., Cappon GD; g Pfizer Worldwide Research & Development , Groton , CT , USA., Chen CL; h ILSI-Health and Environmental Sciences Institute , Washington , DC , USA., Chmielewski G; i Covance Laboratories Inc , Greenfield , IN , USA., De Schaepdrijver L; j Janssen R&D, Preclinical Development & Safety Beerse , Belgium., Enright B; k AbbVie Inc , North Chicago , IL , USA., Foreman JE; l ExxonMobil Biomedical Sciences, Inc , Annandale , NJ , USA., Harrouk W; m U.S. Food & Drug Administration , Silver Spring , MD , USA., Hew KW; n Takeda Pharmaceutical Company , Deerfield , IL , USA., Hoberman AM; o Charles-River Laboratories, Preclinical Services , Horsham , PA , USA., Hui JY; p Celgene Corporation , Summit , NJ , USA., Knudsen TB; q U.S. Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park , NC , USA., Laffan SB; r Safety Assessment, GlaxoSmithKline , King of Prussia , PA , USA., Makris SL; s U.S. Environmental Protection Agency, National Center for Environmental Assessment , Washington , DC , USA., Martin M; q U.S. Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park , NC , USA., McNerney ME; t Drug Safety Evaluation, Bristol-Myers Squibb , New Brunswick , NJ , USA., Siezen CL; b Medicines Evaluation Board , Utrecht , The Netherlands., Stanislaus DJ; r Safety Assessment, GlaxoSmithKline , King of Prussia , PA , USA., Stewart J; u Drug Safety & Metabolism, AstraZeneca , Macclesfield , UK., Thompson KE; t Drug Safety Evaluation, Bristol-Myers Squibb , New Brunswick , NJ , USA., Tornesi B; k AbbVie Inc , North Chicago , IL , USA., Van der Laan JW; a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.; b Medicines Evaluation Board , Utrecht , The Netherlands., Weinbauer GF; v Covance Preclinical Services GmbH , Muenster , Germany., Wood S; w Merck Research Laboratories , Upper Gwynedd , Pennsylvania , USA., Piersma AH; a Centre for Health Protection, National Institute for Public Health and the Environment (RIVM) , Bilthoven , The Netherlands.; x Institute for Risk Assessment Sciences, Faculty of Veterinary Sciences , Utrecht University , Utrecht , The Netherlands.
Publikováno v:
Critical reviews in toxicology [Crit Rev Toxicol] 2016 Nov; Vol. 46 (10), pp. 900-910. Date of Electronic Publication: 2016 Oct 19.