Author response: An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Autor: Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Bjoern Falkenburger, Wolfgang Hoyer, Alexander K Buell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7effea73e940fbda63a10987028cec9c
https://doi.org/10.7554/elife.46112.sa2

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

Autor: Aaron Voigt, Dieter Willbold, Natalie Gasterich, Christopher M. Dobson, Patrick Flagmeier, Alexander K. Buell, Akansha Nagpal, Vibha Prasad, Céline Galvagnion, Björn H. Falkenburger, Hamed Shaykhalishahi, Emil Dandanell Agerschou, Laetitia Heid, Wolfgang Hoyer, Daniel Komnig, Theodora Saridaki

Publikováno v: eLife 8, (2019). doi:10.7554/eLife.46112
eLife
eLife 8, e46112 (2019). doi:10.7554/eLife.46112
eLife, Vol 8 (2019)
Agerschou, E D, Flagmeier, P, Saridaki, T, Galvagnion, C, Komnig, D, Heid, L, Prasad, V, Shaykhalishahi, H, Willbold, D, Dobson, C M, Voigt, A, Falkenburger, B, Hoyer, W & Buell, A K 2019, ' An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils ', eLife, vol. 8, e46112 . https://doi.org/10.7554/eLife.46112

Removing or preventing the formation ofα-synuclein aggregates is a plausible strategy against Parkinson’s disease. To this end we have engineered theβ-wrapin AS69 to bind monomericα-synuclein with high affinity. In cultured cells, AS69 reduced t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a5a4d751956a127fd63daad7e15076