Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Laetitia Bonnary"'
Autor:
Craig S. Harris, Isabelle Cardinaud, Feriel Hacini-Rachinel, Nicolas Rodeville, Audrey Beillard, Arnaud Reitz, Marilyne Bourotte, Benoit Deprez, Laetitia Bonnary, Catherine Comino, Corinne Millois, Delphine Spiesse, Claire Bouix-Peter, Denis Duvert, Jean-Guy Boiteau, Jean-Marie Arlabosse, Yushma Bhurruth-Alcor, Anne-Pascale Luzy, Laurent F. Hennequin, Gaëlle Polge, Emmanuel Vial, Loïc Tomas, Samuel Tabet, Kevin Reverse, Arnaud Mathieu, Artur Pinto, Angélique Feret, Karine Bouquet, Gilles Ouvry, Stéphanie Astri, Nicolas Orsini, Jonathan Pascau, Nathalie Taquet, David Piwnica, Patricia Rossio
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:945-956
Targeting the TNFα pathway is a validated approach to the treatment of psoriasis. In this pathway, TACE stands out as a druggable target and has been the focus of in-house research programs. In this article, we present the discovery of clinical cand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4758b7574647be3dbf23c8335599b665
https://doi.org/10.1016/j.bmc.2017.07.054
https://doi.org/10.1016/j.bmc.2017.07.054
Autor:
Arnaud Reitz, Corinne Millois, Marilyne Bourotte, Feriel Hacini-Rachinel, Carine Rosignoli, Arnaud Mathieu, Sandrine Chambon, Denis Duvert, Anne-Pascale Luzy, Laetitia Bonnary, Gwenaëlle Duvert, Gilles Ouvry, Jonathan Pascau, Craig S. Harris, Benoit Deprez, Laurent F. Hennequin, Catherine Comino, Yushma Bhurruth-Alcor, Yaël Berton, Nathalie Taquet, Claire Bouix-Peter, Gaëlle Polge, Kevin Reverse, Artur Pinto, Karine Bouquet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1848-1853
Targeting the Tumor Necrosis Factor α signalling with antibodies has led to a revolution in the treatment of psoriasis. Locally inhibiting Tumor Necrosis Factor α Converting Enzyme (TACE or ADAM17) could potentially mimic those effects and help tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6d576b781466f2d73bb18129c36d97
https://doi.org/10.1016/j.bmcl.2017.02.035
https://doi.org/10.1016/j.bmcl.2017.02.035
Autor:
Etienne Thoreau, Loïc Tomas, T. Isabet, Laurent Chantalat, Craig S. Harris, Sophie Deret, Alessandro Taddei, Emmanuel Vial, Emeric Varvier, Emilie Borde, Laurent Lamy, Claire Defoin-Platel, Catherine Soulet, Nathalie Taquet, Laetitia Bonnary, Anne-Pascale Luzy, Michèle Aurelly, Laurence Clary, Claire Bouix-Peter, Gilles Ouvry, Laurent F. Hennequin, Mathieu Forissier, Jonathan Pascau
Publikováno v:
ACS Med Chem Lett
[Image: see text] Minor structural modifications—sometimes single atom changes—can have a dramatic impact on the properties of compounds. This is illustrated here on structures related to known mTOR inhibitor Sapanisertib. Subtle changes in the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5530bad5fdbd9b7c5e242653b3983aa
https://pubmed.ncbi.nlm.nih.gov/31749911
https://pubmed.ncbi.nlm.nih.gov/31749911