Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

Autor: Florence Couly, Marine Harari, Carole Dubouilh-Benard, Laetitia Bailly, Emilie Petit, Julien Diharce, Pascal Bonnet, Laurent Meijer, Corinne Fruit, Thierry Besson

Publikováno v: Molecules, Vol 23, Iss 9, p 2181 (2018)

Efficient metal catalyzed C–H arylation of 8-alkyl-thiazolo[5,4-f]-quinazolin-9-ones was explored for SAR studies. Application of this powerful chemical tool at the last stage of the synthesis of kinase inhibitors allowed the synthesis of arrays of

Externí odkaz: https://doaj.org/article/a5c5ba93d71c4074a8e149ffd8cfd7c3

Metalloenzyme‐Mediated Thiol‐Yne Addition Towards Photoisomerizable Fluorescent Dyes

Autor: Alexis Lossouarn, Chloé Puteaux, Laetitia Bailly, Vincent Tognetti, Laurent Joubert, Pierre‐Yves Renard, Cyrille Sabot

Publikováno v: Chemistry – A European Journal. 28

Proteins are able to irreversibly assemble biologically active ligands from building blocks bearing complementary reactive functions due their spatial proximity, through a kinetic target-guided synthetic process (also named in situ click chemistry).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a946e8bd5324adb2b830e8c16c91ea7d
https://doi.org/10.1002/chem.202202180

Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives

Autor: Emilie Corrot, Vincent Levacher, Florian Querniard, Laurent Bischoff, Jean-François Brière, Clémence Fouache, Laetitia Bailly, Alexandra Le Foll, P. Marchand, Emmanuel Deau

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2021, 57, pp.8348-8351. ⟨10.1039/D1CC03477D⟩

International audience; An unprecedented enantioselective conjugate addition reaction of sodium bisulfite to various nitrostyrenes occurred upon the influence of a bifunctional amino-thiourea organocatalyst; a strategy that opens a straightforward ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe230c46b687d777bfd98b842a52f8d
https://hal-normandie-univ.archives-ouvertes.fr/hal-03322399/document

BiCl 3 -Mediated direct functionalization of unsaturated C–C bonds with an electrophilic SCF 2 PO(OEt) 2 reagent

Autor: Tatiana Besset, Xavier Pannecoucke, Jianjun Wang, Emilie Petit, Laetitia Bailly, Heng-Ying Xiong, Thomas Poisson

Publikováno v: Chemical Communications
Chemical Communications, Royal Society of Chemistry, 2019, 55 (60), pp.8784-8787. ⟨10.1039/c9cc01851d⟩
Chemical Communications, Royal Society of Chemistry, 2019, ⟨10.1039/c9cc01851d⟩
Hyper Article en Ligne
Chemical Communications, 2019, 55 (60), pp.8784-8787. ⟨10.1039/c9cc01851d⟩

International audience; A transition metal-free approach was developed for the direct difunctionalization of disubstituted alkynes and terminal alkenes with concomitant formation of C–SCF2PO(OEt)2 and C–Cl bonds. The BiCl3-mediated reaction offer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a96369d2ab5f19618f2008c686a811
https://hal-normandie-univ.archives-ouvertes.fr/hal-02121245

Access to Highly Enantioenriched Donepezil-like 1,4-Dihydropyridines as Promising Anti-Alzheimer Prodrug Candidates via Enantioselective Tsuji Allylation and Organocatalytic Aza-Ene-Type Domino Reactions

Autor: Vincent Levacher, Rabah Azzouz, Emilie Petit, Ludovic Peauger, Vincent Gembus, Mihaela-Liliana Ţînţaş, Cyril Papamicaël, Laetitia Bailly

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2018, 83 (17), pp.10231-10240. ⟨10.1021/acs.joc.8b01442⟩

International audience; This work aims at exploiting both the enantioselective Tsuji allylation of allyl carbonate 6 and an organocatalytic aza-ene-type domino reaction between enal 3a and β-enaminone 4a to develop a straightforward access to all of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c32915afd6ef1875d663e0f8f7c2f9b
https://pubmed.ncbi.nlm.nih.gov/30004228