Zobrazeno 1 - 10 of 42 pro vyhledávání: '"Laetitia, Fend"'
1
Akademický článek
TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment
Autor: Laetitia Fend, Eric Quemeneur, Jean-Baptiste Marchand, Nathalie Silvestre, Johann Foloppe, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fadi Azar, Christelle Demeusoit, Clémentine Spring-Giusti
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background TG6050 was designed as an improved oncolytic vector, combining the intrinsic properties of vaccinia virus to selectively replicate in tumors with the tumor-restricted expression of recombinant immune effectors to modify the tumor immune ph
Externí odkaz: https://doaj.org/article/51ec8ad7965d4c9fa9fa907be1c0686c
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2
Akademický článek
Design and selection of anti-PD-L1 single-domain antibody and tumor necrosis factor superfamily ligands for an optimal vectorization in an oncolytic virus
Autor: Christelle Remy, Elodie Pintado, Marshall Dunlop, Shirley Schön, Patricia Kleinpeter, Homa Rozanes, Laetitia Fend, Renée Brandely, Michel Geist, Delphine Suhner, Eline Winter, Nathalie Silvestre, Claire Huguet, Peter Fitzgerald, Eric Quéméneur, Jean-Baptiste Marchand
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Arming oncolytic viruses with transgenes encoding immunomodulators improves their therapeutic efficacy by enhancing and/or sustaining the innate and adaptive anti-tumoral immune responses. We report here the isolation, selection, and vectorization of
Externí odkaz: https://doaj.org/article/a67cca8ad25a4e0ea646c9801a9e9364
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8
Data from Intravenous Injection of MVA Virus Targets CD8+ Lymphocytes to Tumors to Control Tumor Growth upon Combinatorial Treatment with a TLR9 Agonist
Autor: Xavier Préville, Sylvie Fournel, Sandrine Cochin, Karola Rittner, Emmanuelle Schaedler, Murielle Gantzer, Jacqueline Kintz, Tanja Gatard-Scheikl, Laetitia Fend
Effector T-cell access to tumor tissue is a limiting step for clinical efficacy of antigen-specific T cell–based immunotherapies. Ectopic mouse tumor models, in which a subcutaneously (s.c.) implanted tumor is treated with s.c. or intramuscular the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f7663080d708fe571884c0619a7d3dc
https://doi.org/10.1158/2326-6066.c.6547982.v1
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