Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Laena, Pernomian"'
1
Akademický článek
The Influence of Some Axial Ligands on Ruthenium–Phthalocyanine Complexes: Chemical, Photochemical, and Photobiological Properties
Autor: Tássia Joi Martins, Laisa Bonafim Negri, Laena Pernomian, Kelson do Carmo Freitas Faial, Congcong Xue, Regina N. Akhimie, Michael R. Hamblin, Claudia Turro, Roberto S. da Silva
Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2021)
This work presents a new procedure to synthesize ruthenium–phthalocyanine complexes and uses diverse spectroscopic techniques to characterize trans-[RuCl(Pc)DMSO] (I) (Pc = phthalocyanine) and trans-[Ru(Pc)(4-ampy)2] (II) (4-ampy = 4-aminopyridine)
Externí odkaz: https://doaj.org/article/44a5bc978aea49659da864500449720d
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2
Akademický článek
Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction
Autor: Alejandro F. Prado, Laena Pernomian, Aline Azevedo, Rute A.P. Costa, Elen Rizzi, Junia Ramos, Adriana F. Paes Leme, Lusiane M. Bendhack, Jose E. Tanus-Santos, Raquel F. Gerlach
Publikováno v: Redox Biology, Vol 18, Iss , Pp 181-190 (2018)
Increased reactive oxygen species (ROS) formation may enhance matrix metalloproteinase (MMP)-2 activity and promote cardiovascular dysfunction. We show for the first time that MMP-2 is upstream of increased ROS formation and activates signaling mecha
Externí odkaz: https://doaj.org/article/fe0deb369da74aa592c89176fb3efd02
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4
The janus face of ketone bodies in hypertension
Autor: Tiago J. Costa, Braxton A. Linder, Seth Hester, Milene Fontes, Laena Pernomian, Camilla F. Wenceslau, Austin T. Robinson, Cameron G. McCarthy
Publikováno v: Journal of Hypertension. 40:2111-2119
Hypertension is the most important risk factor for the development of terminal cardiovascular diseases, such as heart failure, chronic kidney disease, and atherosclerosis. Lifestyle interventions to lower blood pressure are generally desirable prior
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c04983e4f043bc78d1d5a4249b71a2
https://doi.org/10.1097/hjh.0000000000003243
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5
TRPM8 channel activation induces relaxation in pudendal artery and corpus cavernosum: Can TRPM8 channel be a target to improve diabetic erectile dysfunction?
Autor: Fernanda Priviero, Raiana Moraes, Fenix Araujo, Rafael Jesus, Liliane Silva, Olufunke Arishe, Laena Pernomian, Camilla Wenceslau, Clinton Webb, Darizy Silva
Publikováno v: Physiology. 38
Erectile dysfunction (ED) is one of the most common and underestimated complications of diabetes. Previous studies have shown that TRPM8 activation triggers relaxation of internal pudendal arteries (IPA) with increased sensitivity in hypertensive rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2139b5db76a8948dbce4e043a5e43f1
https://doi.org/10.1152/physiol.2023.38.s1.5733009
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6
Endothelial Dysfunction and Phenylephrine-Induced Hypocontractility Occurs in Mesenteric Resistance Arteries Prior to the Onset of Alzheimer's Disease in Mice
Autor: Emily W. Waigi, Laena Pernomian, Paul Townsend, Emily W. Wilson, R. Clinton Webb, Cameron G. McCarthy, Camilla F. Wenceslau
Publikováno v: Physiology. 38
Alzheimer’s Disease (AD) is the most common form of dementia and a major cause of disability and death among the older population. In addition, Cardiovascular dieseases (CVDs) and their risk factors are associated with an increased risk of the prog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::949147dc496436242847e187c109898f
https://doi.org/10.1152/physiol.2023.38.s1.5731729
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7
Higher levels of O-GlcNAcylation induce aortic stiffness by increasing elastase activity in male, but not female rats
Autor: Tiago J. Costa, Ian Montandon, Emily Wilson, Milene Fontes, Laena Pernomian, Joseph McQuail, Clinton Webb, Wenceslau Camilla, Cameron McCarthy
Publikováno v: Physiology. 38
Age-associated structural and functional changes in the aorta, including stiffness, loss of elasticity, and reduced vasodilatation, are known to hamper stable peripheral circulation and lead to organ dysfunction. The extracellular matrix (ECM) is a n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aecc57a32d8a0dc592fdfc1ff0bb8aec
https://doi.org/10.1152/physiol.2023.38.s1.5731854
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8
Fentanyl disrupts autoregulation and leads to exacerbated vasodilation in resistance arteries independent of mu-opioid receptor activation
Autor: Paul Townsend Jr, Laena Pernomian, Kawane Moura, Emily Waigi, Emily Wilson, Cameron McCarthy, Camilla Wenceslau
Publikováno v: Physiology. 38
According to the CDC, 107,375 people in the United States died of drug overdoses and poisonings in the 12-month period ending in January 2022 with 67% involving synthetic opioids like fentanyl. Recent studies have implicated the use of prescription o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3f8bbeee4d1ccf99983c9f28775fe5a
https://doi.org/10.1152/physiol.2023.38.s1.5795773
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9
Matrix Metalloproteinase-2 Proteolyzes the Sarcoplasmic Reticulum Calcium ATPase (SERCA), thus Resulting in Morphofunctional Vascular Alterations in Arterial Hypertension
Autor: Marcela Blascke de Mello, Viviano Gomes de Oliveira Neves, Laena Pernomian, Juliana Montenegro Parente, Eduardo Vieira da Rocha, Michele Mazzaron de Castro
Publikováno v: Physiology. 38
Introduction: Arterial hypertension is characterized by matrix metalloproteinase (MMP)-2 increased activity, which proteolyzes extra- and intracellular proteins, thus contributing to cellular migration and proliferation and resulting in vascular remo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e3948af5b266b59d0a1aeae65137b3
https://doi.org/10.1152/physiol.2023.38.s1.5731655
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10
Beta-hydroxybutyrate-induced vasodilation is mediated by Kv7 potassium channels
Autor: Seth Hester, Emily Waigi, Tiago Costa, Emily Wilson, Laena Pernomian, Milene Fontes, Camilla Wenceslau, Cameron McCarthy
Publikováno v: Physiology. 38
Despite the conflicting reports on ketogenic interventions at lowering blood pressure and ameliorating hypertension, we have previously demonstrated that the most abundant ketone body, β-hydroxybutyrate (βOHB) is a novel vasodilator. While the G-pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b0ffb92131703ca5103e4ed33daf49d5
https://doi.org/10.1152/physiol.2023.38.s1.5734168
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