Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Laela M Booshehri"'
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171427 (2017)
The atherosclerotic process begins when vascular endothelial cells undergo pro-inflammatory changes such as aberrant activation to dysfunctional phenotypes and apoptosis, leading to loss of vascular integrity. Our laboratory has demonstrated that exp
Externí odkaz:
https://doaj.org/article/54fbf25a89fa4ee781760eea4322d012
Autor:
Lori Broderick, Shawn Yost, Dong Li, Matthew D. McGeough, Laela M. Booshehri, Marisela Guaderrama, Susannah D. Brydges, Karolina Kucharova, Niraj C. Patel, Margaret Harr, Hakon Hakonarson, Elaine Zackai, Ian G. Cowell, Caroline A. Austin, Boris Hügle, Corinna Gebauer, Jianguo Zhang, Xun Xu, Jian Wang, Ben A. Croker, Kelly A. Frazer, Christopher D. Putnam, Hal M. Hoffman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Topoisomerases are required to release topological stress on DNA during replication and transcription. Here, Broderick et al. report genetic variants in TOP2B that cause a syndromic B cell immunodeficiency associated with reduced TOP2B function, defe
Externí odkaz:
https://doaj.org/article/f68d775e267842bf9a3e97c19180cf33
Autor:
Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M. Booshehri, Janset Onyuru, Aleksandra Leszczynska, Anna Uri, Sven Michel, Richard Klar, Frank Jaschinski, Ariel E. Feldstein, Lori Broderick, Hal M. Hoffman
Publikováno v:
The Journal of Immunology.
Antisense oligonucleotides (ASOs) are a novel therapeutic strategy that targets a specific gene and suppresses its expression. The cryopyrin-associated periodic syndromes (CAPS) are a spectrum of autoinflammatory diseases characterized by systemic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f95f169f17dde312d4ad3a18043bec
https://doi.org/10.4049/jimmunol.2200550
https://doi.org/10.4049/jimmunol.2200550
Autor:
Benedikt, Kaufmann, Lin, Kui, Agustina, Reca, Aleksandra, Leszczynska, Andrea D, Kim, Laela M, Booshehri, Alexander, Wree, Helmut, Friess, Daniel, Hartmann, Lori, Broderick, Hal M, Hoffman, Ariel E, Feldstein
Publikováno v:
Cellular and molecular gastroenterology and hepatology, vol 14, iss 4
Background & aimsNonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. The NLRP3 inflammasome, a platform for caspase-1 activation and release of interleukin 1β, is increasingly recognized in the induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e364dff2322b8c561091b2fae6916409
https://doi.org/10.1016/j.jcmgh.2022.06.007
https://doi.org/10.1016/j.jcmgh.2022.06.007
Autor:
Imran Ullah, Umaru Barrie, Rebecca M. Kernen, Emily T. Mamula, Arani Datta, Laela M. Booshehri, Emma L. Rhodes, James M. Bradford, Dawn M. Wetzel
Leishmaniaspp. are obligate intracellular parasites that must be internalized by phagocytic cells to evade immune responses and cause disease.Leishmaniauptake is thought to be mainly host cell-driven, not parasite-driven. Promastigote (insect-stage)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83dba7c4e511c656844fb6606dc43fc2
https://doi.org/10.1101/2022.11.14.513575
https://doi.org/10.1101/2022.11.14.513575
Autor:
Benedikt Kaufmann, Aleksandra Leszczynska, Agustina Reca, Laela M Booshehri, Janset Onyuru, ZheHao Tan, Alexander Wree, Helmut Friess, Daniel Hartmann, Bettina Papouchado, Lori Broderick, Hal M Hoffman, Ben A Croker, Yanfang Peipei Zhu, Ariel E Feldstein
Publikováno v:
EMBO reports. 23
Sterile inflammation is a central element in liver diseases. The immune response following injurious stimuli involves hepatic infiltration of neutrophils and monocytes. Neutrophils are major effectors of liver inflammation, rapidly recruited to sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324ff9f847072f29c2b870e107de93e8
https://doi.org/10.15252/embr.202154446
https://doi.org/10.15252/embr.202154446
Autor:
Christopher Leija, Suraksha Gahalawat, James M. Bradford, Bin Hu, Joseph M. Ready, Hanspeter Niederstrasser, Imran Ullah, Dawn M. Wetzel, Shreoshi Majumdar, Laela M. Booshehri
Publikováno v:
ACS Infectious Diseases. 6:2057-2072
The few frontline antileishmanial drugs are poorly effective and toxic. To search for new drugs for this neglected tropical disease, we tested the activity of compounds in the Medicines for Malaria Venture (MMV) "Pathogen Box" against Leishmania amaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7f3c2bd152d56b2590646dd1e59e901
https://doi.org/10.1021/acsinfecdis.0c00122
https://doi.org/10.1021/acsinfecdis.0c00122
Autor:
Lori Broderick, Gwendolyn M. Clay, Robert H. Blum, Yang Liu, Rachael McVicar, Fabio Papes, Laela M. Booshehri, Ian G. Cowell, Caroline A. Austin, Christopher D. Putnam, Dan S. Kaufman
Publikováno v:
The Journal of allergy and clinical immunology. 149(6)
Hoffman syndrome is a syndromic, inborn error of immunity due to autosomal-dominant mutations in TOP2B, an essential gene required to alleviate topological stress during DNA replication and gene transcription. Although mutations identified in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576e521c9d1423455b384a4b6b42425b
https://pubmed.ncbi.nlm.nih.gov/35063500
https://pubmed.ncbi.nlm.nih.gov/35063500
Autor:
Hal M. Hoffman, Laela M. Booshehri
Publikováno v:
J Clin Immunol
Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248c57b3a7ad8eeb41398ebe4b35d92
https://doi.org/10.1007/s10875-019-00638-z
https://doi.org/10.1007/s10875-019-00638-z
Autor:
Kaare V. Grunddal, Chiara Tognaccini, Christopher K. Glass, Alexandra Hammond, Philip L.S.M. Gordts, Hal M. Hoffman, Austin W. T. Chiang, Ariane Pessentheiner, Chloe A. Autran, Joanna Latasiewicz, Anthony Quach, Nathanael J. Spann, Lars Bode, Nathan E. Lewis, Laela M. Booshehri, Bastian Ramms, Joseph L. Witztum, Yiwen Wang
SUMMARYMacrophages contribute to the induction and resolution of inflammation and play a central role in the chronic low-grade inflammation in cardiovascular diseases caused by atherosclerosis. Human milk oligosaccharides (HMOs) are complex unconjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78f422a542c02629a2bf759336ec2c7d
https://doi.org/10.1101/2021.03.19.433472
https://doi.org/10.1101/2021.03.19.433472