Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ladislav Sivák"'
Autor:
Martin Studenovský, Anna Rumlerová, Jiřina Kovářová, Barbora Dvořáková, Ladislav Sivák, Libor Kostka, Daniel Berdár, Tomáš Etrych, Marek Kovář
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1201 (2022)
Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubili
Externí odkaz:
https://doaj.org/article/a7795b50f5954a6a94006489cd901eb0
Autor:
Libor Kostka, Ladislav Sivák, Vladimír Šubr, Jiřina Kovářová, Milada Šírová, Blanka Říhová, Radislav Sedlacek, Tomáš Etrych, Marek Kovář
Publikováno v:
Biomacromolecules. 23(6)
The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent P-gp inhibitor and cancerostatic drug inhibiting the proteasome and STAT3 signaling. Therefore, we designed high-mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fa63dd524b409f1cd2bde2cb3226ff
https://pubmed.ncbi.nlm.nih.gov/35584053
https://pubmed.ncbi.nlm.nih.gov/35584053
Autor:
Xueqin Huang, Eugenie Nepovimova, Vojtech Adam, Ladislav Sivak, Zbynek Heger, Marian Valko, Qinghua Wu, Kamil Kuca
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-26 (2024)
Abstract Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matrix metalloproteinase 9, within th
Externí odkaz:
https://doaj.org/article/62a2336fe2ad43b0b5b81b2a4d4bf541
Autor:
Miguel Angel Merlos Rodrigo, Hana Michalkova, Ana Maria Jimenez Jimenez, Frantisek Petrlak, Tomas Do, Ladislav Sivak, Yazan Haddad, Petra Kubickova, Vivian de los Rios, J. Ignacio Casal, Marina Serrano-Macia, Teresa C. Delgado, Loreto Boix, Jordi Bruix, Maria L. Martinez Chantar, Vojtech Adam, Zbynek Heger
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Background & aims Metallothionein-3 (hMT3) is a structurally unique member of the metallothioneins family of low-mass cysteine-rich proteins. hMT3 has poorly characterized functions, and its importance for hepatocellular carcinoma (HCC) cell
Externí odkaz:
https://doaj.org/article/7a0c75ad3012498a9f15fd7e736949c9
Autor:
Libor Kostka, Jiřina Kovářová, Michal Kraus, Radislav Sedlacek, Jitka Fucikova, Radek Spisek, Ladislav Sivák, Milada Šírová, Eva Randárová, Blanka Říhová, Barbora Dvořáková, Michaela Vondráčková, Petr Makovický, Tomáš Etrych, Sarka Vosahlikova, Vladimir Subr, Marek Kovář, Martin Studenovský, Jakub Tomala
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 332
Drug repurposing is a promising strategy for identifying new applications for approved drugs. Here, we describe a polymer biomaterial composed of the antiretroviral drug ritonavir derivative (5-methyl-4-oxohexanoic acid ritonavir ester; RD), covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3112a15f63a96388f784441033a5699f
https://pubmed.ncbi.nlm.nih.gov/33722611
https://pubmed.ncbi.nlm.nih.gov/33722611
Autor:
Tomas Eckschlager, Ladislav Sivák, Lucie Cuchalová, Jan Hraběta, Zuzana Hvězdová, Eva Koziolová, Karel Ulbrich, Tomáš Etrych, Vladimir Subr, Olga Janoušková
Publikováno v:
Journal of Controlled Release. 233:136-146
Water-soluble N -(2-hydroxypropyl)methacrylamide copolymer conjugates bearing the anticancer drugs doxorubicin (Dox) or pirarubicin (THP), P-gp inhibitors derived from reversin 121 (REV) or ritonavir (RIT)), or both anticancer drug and P-gp inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f98e48e397c24c15e8fda9d3540b04b
https://doi.org/10.1016/j.jconrel.2016.05.036
https://doi.org/10.1016/j.jconrel.2016.05.036
Autor:
Xueqin Huang, Li You, Eugenie Nepovimova, Miroslav Psotka, David Malinak, Marian Valko, Ladislav Sivak, Jan Korabecny, Zbynek Heger, Vojtech Adam, Qinghua Wu, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberrant stimu
Externí odkaz:
https://doaj.org/article/2625c42c0d07439f92419713efaf92ad
Autor:
Eliska Prchalova, Martina Sukupova, David Malinak, Rudolf Andrys, Ladislav Sivak, Vladimir Pekarik, Adam Skarka, Jana Svobodova, Lukas Prchal, Lukas Fresser, Zbynek Heger, Kamil Musilek
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115490- (2023)
The BODIPY-labelled oxime reactivator was prepared and used to study its biodistribution into central nervous system. The newly synthesized oxime was found to be weak inhibitor of acetylcholinesterase and strong inhibitor of butyrylcholinesterase. It
Externí odkaz:
https://doaj.org/article/e1552502a55f468193830aae36c102b1
Autor:
Rafał Konefał, Marek Kovar, Ladislav Sivák, Ondrej Sedlacek, Martin Studenovsky, Veronika Horkova, Blanka Rihova, Milada Šírová, T Etrych
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 269
The delivery of nitric oxide (NO) specifically to solid tumours was explored in this study as a strategy to augment the passive accumulation of nanomedicines in tumours induced by the Enhanced Permeability and Retention (EPR) effect. An increase in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c87193de27de62f38552e8a186361f
https://pubmed.ncbi.nlm.nih.gov/29154977
https://pubmed.ncbi.nlm.nih.gov/29154977
Autor:
Alena Braunová, Eva Koziolová, Michal Pechar, Marek Kovář, Vladimir Subr, Blanka Říhová, Karel Ulbrich, Jiří Strohalm, Ladislav Sivák, Martina Kabesova
Publikováno v:
Biomacromolecules. 15:3030-3043
The effects of novel polymeric therapeutics based on water-soluble N-(2-hydroxypropyl)methacrylamide copolymers (P(HPMA)) bearing the anticancer drug doxorubicin (Dox), an inhibitor of ABC transporters, or both, on the viability and the proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fd6607ba0dbe845246ea34d6c809e3
https://doi.org/10.1021/bm500649q
https://doi.org/10.1021/bm500649q