Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Ladislav Andera"'
Autor:
Diana Malarikova, Radek Jorda, Kristyna Kupcova, Jana Senavova, Alexandra Dolnikova, Eva Pokorna, Dmitry Kazantsev, Kristina Nozickova, Dana Sovilj, Celine Bellanger, David Chiron, Ladislav Andera, Vladimir Krystof, Miroslav Strnad, Karel Helman, Magdalena Klanova, Marek Trneny, Ondrej Havranek, Pavel Klener
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2024)
Abstract Background Mantle cell lymphoma (MCL) is a chronically relapsing malignancy with deregulated cell cycle progression. We analyzed efficacy, mode of action, and predictive markers of susceptibility to palbociclib, an approved CDK 4/6 inhibitor
Externí odkaz:
https://doaj.org/article/66f0f83138da43c8bb386bfcf004df4c
Autor:
Josef Horak, Alexandra Dolnikova, Ozge Cumaogullari, Andrea Cumova, Nazila Navvabi, Ludmila Vodickova, Miroslav Levy, Michaela Schneiderova, Vaclav Liska, Ladislav Andera, Pavel Vodicka, Alena Opattova
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cancer therapy failure is a fundamental challenge in cancer treatment. One of the most common reasons for therapy failure is the development of acquired resistance of cancer cells. DNA-damaging agents are frequently used in first-line chemotherapy re
Externí odkaz:
https://doaj.org/article/3522c5a78afe4cca8e6b702e06abe405
Autor:
Sona Stemberkova‐Hubackova, Renata Zobalova, Maria Dubisova, Jana Smigova, Sarka Dvorakova, Klara Korinkova, Zuzana Ezrova, Berwini Endaya, Kristyna Blazkova, Erik Vlcak, Petra Brisudova, Dan‐Diem Thi Le, Stefan Juhas, Daniel Rosel, Cristina Daniela Kelemen, Dana Sovilj, Eliska Vacurova, Tomas Cajka, Vlada Filimonenko, Lanfeng Dong, Ladislav Andera, Pavel Hozak, Jan Brabek, Zuzana Bielcikova, Jan Stursa, Lukas Werner, Jiri Neuzil
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/6ffa7e718404400f926a4f1d5c918cd7
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10157 (2021)
Hematologic malignancies (HM) comprise diverse cancers of lymphoid and myeloid origin, including lymphomas (approx. 40%), chronic lymphocytic leukemia (CLL, approx. 15%), multiple myeloma (MM, approx. 15%), acute myeloid leukemia (AML, approx. 10%),
Externí odkaz:
https://doaj.org/article/ec23120be87d498b8670e64573f6add6
Publikováno v:
Cancers, Vol 13, Iss 3, p 479 (2021)
The disruption of genomic integrity due to the accumulation of various kinds of DNA damage, deficient DNA repair capacity, and telomere shortening constitute the hallmarks of malignant diseases. DNA damage response (DDR) is a signaling network to pro
Externí odkaz:
https://doaj.org/article/6aa0fde66eef4a2189f8dff6f83e9a76
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 246-252 (2016)
Multifunctional adapter and chaperone protein Daxx participates in the regulation of a number of mainly transcription-related processes. Most notably in a complex with chromatin-remodelling ATPase ATRX, Daxx serves as a histone H3.3 chaperone at telo
Externí odkaz:
https://doaj.org/article/5f41b3fe813d4cb7bf09983fd1be254a
Autor:
Lan-Feng Dong, Jaromira Kovarova, Martina Bajzikova, Ayenachew Bezawork-Geleta, David Svec, Berwini Endaya, Karishma Sachaphibulkij, Ana R Coelho, Natasa Sebkova, Anna Ruzickova, An S Tan, Katarina Kluckova, Kristyna Judasova, Katerina Zamecnikova, Zuzana Rychtarcikova, Vinod Gopalan, Ladislav Andera, Margarita Sobol, Bing Yan, Bijay Pattnaik, Naveen Bhatraju, Jaroslav Truksa, Pavel Stopka, Pavel Hozak, Alfred K Lam, Radislav Sedlacek, Paulo J Oliveira, Mikael Kubista, Anurag Agrawal, Katerina Dvorakova-Hortova, Jakub Rohlena, Michael V Berridge, Jiri Neuzil
Publikováno v:
eLife, Vol 6 (2017)
Recently, we showed that generation of tumours in syngeneic mice by cells devoid of mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However, the mechanism of mtDNA movement between cells remains unresolved. To deter
Externí odkaz:
https://doaj.org/article/4285105d6a3d4ae5a57e35604fc4c03d
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21632 (2011)
Documented sensitivity of melanoma cells to PLX4720, a selective BRAFV600E inhibitor, is based on the presence of mutant BRAF(V600E) alone, while wt-BRAF or mutated KRAS result in cell proliferation. In colon cancer appearance of oncogenic alteration
Externí odkaz:
https://doaj.org/article/acc1cb7e07b24d4da854c8236855f719
Autor:
Pavel Klener, Marek Trneny, Eva Fronkova, Adela Berkova, Petra Vockova, Mariana Pacheco-Blanco, Kristina Forsterova, Karel Helman, Eva Pokorna, Diana Tuskova, Zuzana Zemanova, Karla Svobodova, Jan Soukup, Ondrej Havranek, Magdalena Klanova, Michael Svaton, Jana Karolova, Zuzana Nahacka, Ladislav Andera, Dana Prukova
Purpose:Mantle cell lymphoma (MCL) is an aggressive subtype of B-cell non-Hodgkin lymphomas characterized by (over)expression of BCL2. A BCL2-targeting drug, venetoclax, has promising anticancer activity in MCL. We analyzed molecular mechanisms of ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f5c886ce44042199a0881ea8008748
https://doi.org/10.1158/1078-0432.c.6528017
https://doi.org/10.1158/1078-0432.c.6528017
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Western blot analysis showing protein expression profile of key regulators of apoptosis in 18 DLBCL cell lines (12 germinal center B-cell-like (GCB) and 6 activated B-cell-like (ABC) DLBCL cell lines). *UPF4D cell line (GCB origin) was derived in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c173972cf2e268702b74b82a1e49d1e3
https://doi.org/10.1158/1078-0432.22457130
https://doi.org/10.1158/1078-0432.22457130