Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ladina DiRago"'
Autor:
Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically c
Externí odkaz:
https://doaj.org/article/6cd266dc641c4e128ba4ff9c8fb14771
Autor:
Hannah D. Coughlan, Helen Ierino, Timothy M. Johanson, Melissa J. Davis, Mark A. Dawson, Anna Gabrielyan, Charles C. Bell, Kira Behrens, Warren S. Alexander, Tracy A. Willson, Yih-Chih Chan, Stephen L. Nutt, Andrew J. Kueh, Sandra Mifsud, Elizabeth M. Viney, Michael Sze Yuan Low, Rhys S. Allan, Gordon K. Smyth, Marco J Herold, Thomas Boudier, Ladina DiRago, Kelly L. Rogers, David M Tarlinton, Rebecca Feltham, Omer Gilan, Ashley P. Ng, Craig D. Hyland, Soroor Hediyeh-Zadeh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
B lymphoid development is initiated by the differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating mature B cells. This highly regulated process generates clonal immunological diversity via recombination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60953635fcec00c01cd1318750a49893
http://link.springer.com/article/10.1038/s41467-020-16828-y
http://link.springer.com/article/10.1038/s41467-020-16828-y
Autor:
Dina Stockwell, Nicos A. Nicola, Alan Ching, Satoshi Ishido, Douglas J. Hilton, Jeffrey J. Babon, Warren S. Alexander, Artem Laktyushin, Jose A Villadangos, Jian-Guo Zhang, Ladina DiRago
Publikováno v:
Biochemical Journal. 476:2869-2882
Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used the ability of IL6 to inhibit the clonal proliferation of the mouse M1 myeloid leukemia cell line in agar to positively screen a cDNA exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a5d911c84c5406b79d2cf899425ff4
https://doi.org/10.1042/bcj20190577
https://doi.org/10.1042/bcj20190577
Autor:
Omer Gilan, Helen Ierino, Soroor Hediyeh-Zadeh, Thomas Boudier, Kira Behrens, Tracy A. Willson, Andrew J. Kueh, Ladina DiRago, Warren S. Alexander, Stephen L. Nutt, Kelly L. Rogers, Yih-Chih Chan, Timothy M. Johanson, Sandra Mifsud, Rhys S. Allan, Melissa J. Davis, Mark A. Dawson, Hannah D. Coughlan, Charles C. Bell, Elizabeth M. Viney, Michael Sze Yuan Low, Ashley P. Ng, Craig D. Hyland, Gordon K. Smyth, Marco J Herold, David M. Tarlinton
Summary/AbstractB-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committed progenitors, ultimately generating the mature B-cells that mediate protective immunity. This highly regulated process a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964a341948061671b72d3f82a6840407
https://doi.org/10.1101/861542
https://doi.org/10.1101/861542
Autor:
Kate E. Lawlor, Man K.S. Lee, Donald Metcalf, Seth L. Masters, Dragana Dragoljevic, Ajithkumarx Vasanthakumar, Andrew J. Murphy, Ben A. Croker, Motti Gerlic, James E Vince, Benjamin T. Kile, Louise H. Cengia, Mark A. Febbraio, Ladina DiRago, John M. Wentworth, Helene L. Kammoun, Leonard C. Harrison, Rachael M. Lane, Michael J Kraakman, Lachlan Whitehead, Axel Kallies
Publikováno v:
Cell Metabolism. 23:155-164
Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and has anti-obesity effects; however, it is not known which inflammasome regulates this process. We found that mice lacking the NLRP1 inflammasome phenocopy mice lacking IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b561c38a7f45e3450489e2d37179ed0
https://doi.org/10.1016/j.cmet.2015.09.024
https://doi.org/10.1016/j.cmet.2015.09.024
Autor:
Dena Lyras, Hyun-Ja Ko, Ben A. Croker, Andrew W. Roberts, Seth L. Masters, Ladina DiRago, Hazel Tye, Benjamin T. Kile, Daniel L. Kastner, Louise H. Cengia, Andrew M. Lew, Dominic De Nardo, Donald Metcalf, Yong Hwan Park, Jae Jin Chae, Man Lyang Kim, Roslynn A. Stirzaker
Publikováno v:
The Journal of Experimental Medicine
Kim et al. identify an autoinflammatory disease in mice that is driven by IL-18, resulting from an inactivating mutation in the actin-depolymerizing cofactor Wdr1. This alteration in actin dynamics is recognized by the pyrin inflammasome and results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d083a9dd16f2d64e6951e613d1d289
https://doi.org/10.1084/jem.20142384
https://doi.org/10.1084/jem.20142384
Autor:
Andrew J. Murphy, Grace Liu, Giovanna Pomilio, Cécile Esnault, Meaghan Wall, Andrew H. Wei, Ladina DiRago, Margherita Ghisi, Donald Metcalf, Emilia Simankowicz, Mark A. Dawson, Luyi Tian, Shalin H. Naik, Stephen L. Nutt, Charles C. Bell, Michael Erlichster, Pavle Krsmanovic, Ruijie Liu, Shian Su, Ethan P. Oxley, Luisa Cimmino, Matthew T. Witkowski, Aleksandar Dakic, Matthew E. Ritchie, Johannes Zuber, Tina Vu, Ricky W. Johnstone, Nouraiz Ahmed, Daniela Zalcenstein, Timm Schroeder, Steven Ngo, Tracey M. Baldwin, Mark D. McKenzie, Jessica M. Salmon, V Pospisil, Graeme I. Lancaster, Ross A. Dickins, Shu Wang, Michael Chopin, Ben A. Croker
Publikováno v:
Cell Stem Cell, 25 (2)
Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an immature subpopulation of tumor-propagating cancer stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99d7663967872663054760f01f2c8f9
https://doi.org/10.1016/j.stem.2019.07.001
https://doi.org/10.1016/j.stem.2019.07.001
Autor:
Warren S. Alexander, Ladina DiRago, Craig D. Hyland, Sandra Mifsud, Nicos A. Nicola, Donald Metcalf, Douglas J. Hilton, Marina R. Carpinelli
Publikováno v:
Blood. 105:3480-3487
Mpl -/- mice bearing the Plt3 or Plt4 mutations in the c-Myb gene exhibit thrombopoietin (TPO)–independent supraphysiological platelet production accompanied by excessive megakaryocytopoiesis and defective erythroid and lymphoid cell production. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ffb173b5d931444089135483677fe3d
https://doi.org/10.1182/blood-2004-12-4806
https://doi.org/10.1182/blood-2004-12-4806
Autor:
Matthew E. Ritchie, Ethan P. Oxley, Ross A. Dickins, Matthew T. Witkowski, Meaghan Wall, Grace Liu, Emilia Simankowicz, Donald Metcalf, Aleksandar Dakic, Johannes Zuber, Luisa Cimmino, Stephen L. Nutt, Michael Erlichster, Mark D. McKenzie, Ladina DiRago, Margherita Ghisi, Cynthia Liu
Publikováno v:
Blood. 128:3930-3930
Background: Acute myeloid leukemia (AML) is an aggressive malignancy characterized by clonal expansion of transformed myeloid precursors that fail to differentiate into mature cells. Since myeloid lineage maturation curbs self-renewal and is consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8661b35381437864c72441fc11cfdaf0
https://doi.org/10.1182/blood.v128.22.3930.3930
https://doi.org/10.1182/blood.v128.22.3930.3930
Autor:
Sandra Mifsud, Donald Metcalf, Ladina DiRago, Samantha A. Dagger, Angela C. Chan, Adam H. Hart, Lorraine Robb, Angela D'Amico, Stefan P Glaser, David J. Izon, Chiara Campo, Li Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 103(44)
Mixl1 , the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis. Gene targeting and overexpression studies have implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554ce26bd7763d991266caf15d93f072
https://pubmed.ncbi.nlm.nih.gov/17060613
https://pubmed.ncbi.nlm.nih.gov/17060613