Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ladell, Kristin Ingrid"'
Autor:
Dockree, Tamsin, Holland, Christopher J., Clement, Mathew, Ladell, Kristin Ingrid, McLaren, James Edward, Van Den Berg, Hugo A., Gostick, Emma, Llewellyn-Lacey, Sian, Man, Stephen Tzekwung, Bailey, Mick, Burrows, Scott, Price, David, Wooldridge, Linda
The CD8 coreceptor engages peptide-major histocompatibility complex class I (pMHCI) molecules at a largely invariant site distinct from the T-cell receptor (TCR) binding platform and enhances the sensitivity of antigen-driven activation to promote ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::8c2acdfafc8ac58a7f51352c49de0328
https://orca.cardiff.ac.uk/id/eprint/94125/1/icb201685a.pdf
https://orca.cardiff.ac.uk/id/eprint/94125/1/icb201685a.pdf
Autor:
Dolton, Garry Michael, Lissina, A., Skowera, A., Ladell, Kristin Ingrid, Tungatt, Katie, Jones, Emma, Kronenberg-Versteeg, D., Akpovwa, Hephzibah, Pentier, Johanne, Holland, C. J., Godkin, Andrew James, Cole, David, Neller, M. A., Miles, John James, Price, David, Peakman, M., Sewell, Andrew K.
Publikováno v:
Clinical and Experimental Immunology
Fluorochrome-conjugated peptide–major histocompatibility complex (pMHC) multimers are widely used for flow cytometric visualization of antigen-specific T cells. The most common multimers, streptavidin–biotin-based ‘tetramers’, can be manufact
Autor:
Scurr, Martin John, Ladell, Kristin Ingrid, Besneux, Matthieu, Christian, Adam, Hockey, T., Smart, Kathryn, Bridgeman, Hayley, Hargest, Rachel, Phillips, S., Davies, M., Price, David, Gallimore, Awen Myfanwy, Godkin, Andrew James
Publikováno v:
Mucosal Immunology
Although elevated CD4+Foxp3+ regulatory T cell (Treg) frequencies within tumors are well documented, the functional and phenotypic characteristics of CD4+Foxp3+ and CD4+Foxp3− T cell subsets from matched blood, healthy colon, and colorectal cancer
Autor:
Kløverpris, Henrik N., McGregor, Reuben, McLaren, James Edward, Ladell, Kristin Ingrid, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David, Goulder, Philip
Objectives: Although CD8+ T cells play a critical role in the control of HIV-1 infection, their antiviral efficacy can be limited by antigenic variation and immune exhaustion. The latter phenomenon is characterized by the upregulation of multiple inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::371420cda2e54d27a4faa7f3c324b35a
https://doi.org/10.1097/qad.0000000000000362
https://doi.org/10.1097/qad.0000000000000362
Autor:
Neller, Michelle A., Ladell, Kristin Ingrid, McLaren, James Edward, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew, Wooldridge, Linda, Cole, David, van Baarle, Debbie, Sewell, Andrew K., Burrows, Scott R., Price, David, Miles, John James
Publikováno v:
A Neller, M, Ladell, K, McLaren, J E, K Matthews, K, Gostick, E, M Pentier, J, Dolton, G, JA Schauenburg, A, Koning, D, Costa, A, Watkins, T, Venturi, V, Smith, C, Khanna, R, Miners, K, Clement, M, Wooldridge, L, Cole, D K, van Baarle, D, Sewell, A K, Burrows, S R, Price, D A & Miles, J J 2015, ' Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics ', Immunology and Cell Biology, vol. 93, no. 7, pp. 625-633 . https://doi.org/10.1038/icb.2015.17
Basic parameters of the naive antigen (Ag)-specific T-cell repertoire in humans remain poorly defined. Systematic characterization of this 'ground state' immunity in comparison with memory will allow a better understanding of clonal selection during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a7e18820efd37d64076962c9c6af0282
https://hdl.handle.net/1983/28ec37a8-f20c-4c34-aa3e-7e12902ccbb8
https://hdl.handle.net/1983/28ec37a8-f20c-4c34-aa3e-7e12902ccbb8
Autor:
Tan, Mai, Gerry, A. B., Brewer, J. E., Melchiori, L., Bridgeman, John S., Bennett, A. D., Pumphrey, N. J., Jakobsen, B. K., Price, D. A., Ladell, Kristin Ingrid, Sewell, Andrew K.
Antigen-specific T cell receptor (TCR) gene transfer via patient-derived T cells is an attractive approach to cancer therapy, with the potential to circumvent immune regulatory networks. However, high-affinity tumour-specific TCR clonotypes are typic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5c15e0ecb4f8f11acb8b55a09445953c
Autor:
Ondondo, Beatrice, Jones, Emma, Hindley, James, Cutting, Scott, Smart, Kathryn, Bridgeman, Hayley, Matthews, Katherine K., Ladell, Kristin Ingrid, Price, David, Jackson, David G., Godkin, Andrew James, Ager, Ann, Gallimore, Awen Myfanwy
The tumor microenvironment comprises newly formed blood and lymphatic vessels which shape the influx, retention and departure of lymphocytes within the tumor mass. Thus, by influencing the intratumoral composition of lymphocytes, these vessels affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::617d65f949c6959a0f4f3a19d72183cf
https://orca.cardiff.ac.uk/id/eprint/61252/1/WOA-20132014-19.pdf
https://orca.cardiff.ac.uk/id/eprint/61252/1/WOA-20132014-19.pdf
Autor:
Bridgeman, John S., Ladell, Kristin Ingrid, Sheard, V. E., Miners, Kelly Louise, Hawkins, R. E., Price, David, Gilham, D. E.
Chimeric antigen receptors (CARs) can mediate redirected lysis of tumour cells in a major histocompatibility complex (MHC)-independent manner, thereby enabling autologous adoptive T cell therapy for a variety of malignant neoplasms. Currently, most C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::419d018047ba54e53aa4a620de0d0968
Autor:
Doherty, T. Mark, Antrobus, Richard D., Lillie, Patrick J., Berthoud, Tamara K., Spencer, Alexandra J., McLaren, James E., Ladell, Kristin Ingrid, Lambe, Teresa, Milicic, Anita, Price, David, Hill, Adrian V. S., Gilbert, Sarah C.
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48322 (2012)
PLoS ONE
PLoS ONE
BACKGROUND: Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in older adults. We assessed the safety and immunogenicity of MVA-NP+M1, a viral-vectored influenza vaccine designed to boost memory T cell responses, in
Autor:
Ladell, Kristin Ingrid
Effective immunity is fundamental to life on a dirty planet. Appropriate immune responses control infections and protect against cancer. Inappropriate immune responses lead to autoimmunity and allergy. A fine balance between aggression and tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::5e23f44d02b1ef57fed832f843df9dc4
https://orca.cardiff.ac.uk/id/eprint/46990/1/2013LADELkiphd.pdf
https://orca.cardiff.ac.uk/id/eprint/46990/1/2013LADELkiphd.pdf