Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort.

Autor: Jansen MP; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Wirth W; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Chondrometrics GmbH, Freilassing, Germany., Bacardit J; School of Computing, Newcastle University, Newcastle, UK., van Helvoort EM; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Marijnissen ACA; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Blanco FJ; Grupo de Investigación de Reumatología (GIR), INIBIC-Complejo Hospitalario Universitario de A Coruña, SERGAS, Centro de Investigación CICA, Departamento de Fisioterapia y Medicina, Universidad de A Coruña, A Coruña, SpainServicio de Reumatologia, INIBIC-Universidade de A Coruña, A Coruña, Spain., Haugen IK; Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway., Berenbaum F; Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France.; INSERM, Sorbonne University, Paris, France., Ladel CH; Independent Consultant, Darmstadt, Germany., Loef M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Lafeber FPJG; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Welsing PM; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Mastbergen SC; Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Roemer FW; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.; Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Publikováno v: Quantitative imaging in medicine and surgery [Quant Imaging Med Surg] 2023 May 01; Vol. 13 (5), pp. 3298-3306. Date of Electronic Publication: 2023 Mar 10.

Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort.

Autor: Roemer FW; Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Maximiliansplatz 3, 91054, Erlangen, Germany. frank.roemer@uk-erlangen.de.; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA. frank.roemer@uk-erlangen.de., Jansen M; University Medical Center Utrecht, Utrecht, The Netherlands., Marijnissen ACA; University Medical Center Utrecht, Utrecht, The Netherlands., Guermazi A; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.; Department of Radiology, VA Boston Healthcare System, West Roxbury, MA, USA., Heiss R; Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Maximiliansplatz 3, 91054, Erlangen, Germany., Maschek S; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria., Lalande A; Institut de Recherches Internationales Servier, Suresnes, France., Blanco FJ; Servicio de Reumatologia, INIBIC- Universidade de A Coruña, A Coruña, Spain., Berenbaum F; Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France.; INSERM, Sorbonne University, Paris, France., van de Stadt LA; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Haugen IK; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway., Ladel CH; Independent Consultant, Darmstadt, Germany., Bacardit J; School of Computing, Newcastle University, Newcastle, UK., Wisser A; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria., Eckstein F; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria., Lafeber FPJG; University Medical Center Utrecht, Utrecht, The Netherlands., Weinans HH; University Medical Center Utrecht, Utrecht, The Netherlands., Wirth W; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.

Publikováno v: BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2022 Nov 17; Vol. 23 (1), pp. 988. Date of Electronic Publication: 2022 Nov 17.

Pain sensitivity genes as therapeutic targets in knee osteoarthritis: A comprehensive analysis.

Autor: Li, Zirui¹ (AUTHOR), Chen, Haicheng² (AUTHOR), Chen, Chujie¹ (AUTHOR) chujiechen369@outlook.com

Publikováno v: Molecular Pain. 10/3/2024, p1-12. 12p.

Tissue distribution of sprifermin (recombinant human fibroblast growth factor 18) in the rat following intravenous and intra-articular injection.

Autor: Ladel CH; Merck KGaA, 64293, Darmstadt, Germany., Barbero L; Merck Serono Ivrea Research Centre, 10010, Colleretto Giacosa, Italy., Riva S; Merck Serono Ivrea Research Centre, 10010, Colleretto Giacosa, Italy., Guehring H; Merck KGaA, 64293, Darmstadt, Germany.

Publikováno v: Osteoarthritis and cartilage open [Osteoarthr Cartil Open] 2020 Apr 25; Vol. 2 (3), pp. 100068. Date of Electronic Publication: 2020 Apr 25 (Print Publication: 2020).

Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017.

Autor: Smith TO; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Mansfield M; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Hawker GA; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Hunter DJ; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., March LM; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Boers M; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Shea BJ; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Christensen R; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Guillemin F; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Terwee CB; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Williamson PR; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Roos EM; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Loeser RF; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Schnitzer TJ; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Kloppenburg M; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Neogi T; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Ladel CH; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Kalsi G; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Kaiser U; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Buttel TW; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Ashford AE; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Mobasheri A; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Arden NK; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Tennant A; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Hochberg MC; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., de Wit M; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Tugwell P; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC., Conaghan PG; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford; School of Health and Social Care, London South Bank University, London; Institute of Translational Medicine, University of Liverpool, Liverpool; Faculty of Health and Medical Sciences, University of Surrey, Guildford; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), Leeds, UK; Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital, Sydney, Australia; Department of Epidemiology and Biostatistics, Amsterdam University Medical Centres, location VUmc; Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health, Amsterdam; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands; Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark; Université de Lorraine, APEMAC, Nancy, France; Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, North Carolina; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago; Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine, Boston; TissueGene Inc., Rockville; Division of Rheumatology and Clinical Immunology, Department of Medicine and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA; Merck Biopharma, Merck KGaA, Darmstadt; University Pain Centre, University Hospital Carl Gustav Carus, Dresden, Germany; Inner West Psychology; Institute of Bone and Joint Research, Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, Australia; Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; Faculty of Humanities and Social Sciences, University of Lucerne, Lucerne, Switzerland. p.conaghan@leeds.ac.uk.; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford BRC, John Radcliffe Hospital, Oxford; M. Mansfield, MSc, Senior Lecturer in Physiotherapy, School of Health and Social Care, London South Bank University; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of Medicine, and Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto; D.J. Hunter, PhD, Florance and Cope Chair of Rheumatology Chair of Institute of Bone and Joint Research Professor of Medicine, Institute of Bone and Joint Research, Florance and Cope and Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; L.M. March, PhD, Liggins Professor of Rheumatology and Musculosketal Epidemiology Medicine, Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; M. Boers, PhD, Professor of Clinical Epidemiology, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; B.J. Shea, PhD, Adjunct Professor, Ottawa Hospital Research Institute; R. Christensen, PhD, Professor of Biostatistics and Clinical Epidemiology, Musculoskeletal Statistics Unit, the Parker Institute, Bispebjerg and Frederiksberg Hospital and Department of Rheumatology, Odense University Hospital; F. Guillemin, PhD, Professor of Epidemiology and Public Health, Université de Lorraine, APEMAC; C.B. Terwee, PhD, Associate Professor in Clinimetrics, Department of Epidemiology and Biostatistics, Amsterdam University Medical Centers; P.R. Williamson, PhD, Professor of Medical Statistics, Institute of Translational Medicine, University of Liverpool; E.M. Roos, PhD, Professor, Head of Research Unit, Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark; R.F. Loeser, MD, Herman and Louise Smith Distinguished Professor of Medicine, Division of Rheumatology, Allergy and Immunology, and Division of Rheumatology, Allergy and Immunology, Thurston Arthritis Research Center, University of North Carolina; T.J. Schnitzer, PhD, Professor of Physical Medicine and Rehabilitation, Anesthesiology and Medicine (Rheumatology), and Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine; M. Kloppenburg, PhD, Professor in Rheumatology, Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre; T. Neogi, PhD, Professor, Epidemiology, Sections of Clinical Epidemiology and Rheumatology, Boston University School of Medicine; C.H. Ladel, PhD, Clinical Biomarker and Diagnostics Lead, Merck Biopharma, Merck KGaA; G. Kalsi, MD, Chief Medical Officer, Senior Vice President of Clinical Development and Regulatory and Medical Affairs, TissueGene Inc.; U. Kaiser, PhD, Principal Investigator, University Pain Centre, University Hospital Carl Gustav Carus; T.W. Buttel, MA, Psychologist, Inner West Psychology, and Institute of Bone and Joint Research, Florance and Cope Professorial Department of Rheumatology, School of Medicine, University of Sydney and Royal North Shore Hospital; A.E. Ashford, PhD, Emeritus Professor, School of Biological, Earth and Environmental Sciences, University of New South Wales; A. Mobasheri, DPhil, Professor of Musculoskeletal Physiology, Faculty of Health and Medical Sciences, University of Surrey, and Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine; N.K. Arden, MD, Professor in Rheumatic Diseases, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; A. Tennant, PhD, Permanent Visiting Professor, Faculty of Humanities and Social Sciences, University of Lucerne; M.C. Hochberg, MD, Professor of Medicine and Epidemiology and Public Health, Division of Rheumatology and Clinical Immunology, Department of Medicine, and Division of Gerontology, Department of Epidemiology and Public Health, University of Maryland School of Medicine; M. de Wit, PhD, Visiting Fellow, Amsterdam University Medical Centre, Department of Medical Humanities, Amsterdam Public Health; P. Tugwell, PhD, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; P.G. Conaghan, PhD, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds BRC. p.conaghan@leeds.ac.uk.

Publikováno v: The Journal of rheumatology [J Rheumatol] 2019 Aug; Vol. 46 (8), pp. 976-980. Date of Electronic Publication: 2019 Mar 01.