Precision needle-punch tumor enrichment from paraffin blocks improves the detection of clinically actionable genomic alterations and biomarkers.

Autor: Lin DI; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Huang RSP; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Ladas I; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Keller RB; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Patel NR; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Lakis S; Foundation Medicine GmbH, Pathology Department, Penzberg, Germany., Decker B; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Janovitz T; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Mata DA; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Ross JS; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Vergilio JA; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Elvin JA; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States., Herbst RS; Department of Medical Oncology, Yale School of Medicine, Yale Cancer Center, New Haven, CT, United States., Mack PC; Division of Hematology and Oncology, Department of Medicine, Tisch Cancer Institute at Mount Sinai, New York, NY, United States., Killian JK; Department of Pathology and Diagnostic Medicine, Foundation Medicine, Inc., Cambridge, MA, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Feb 20; Vol. 14, pp. 1328512. Date of Electronic Publication: 2024 Feb 20 (Print Publication: 2024).

Esr1 napa assay: Development and analytical validation of a highly sensitive and specific blood‐based assay for the detection of ESR1 mutations in liquid biopsies

Autor: Stergiopoulou, D. Markou, A. Tzanikou, E. Ladas, I. Mike Makrigiorgos, G. Georgoulias, V. Lianidou, E.

A considerable number of estrogen receptor‐positive breast cancer (ER+ BrCa) patients develop resistance to endocrine treatment. One of the most important resistance mechanisms is the presence of ESR1 mutations. We developed and analytically valida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::c7d2a93d2c70509358ad9475954f359b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3077172

Nuclease-Assisted Minor Allele Enrichment Using Overlapping Probes-Assisted Amplification-Refractory Mutation System: An Approach for the Improvement of Amplification-Refractory Mutation System-Polymerase Chain Reaction Specificity in Liquid Biopsies

Autor: Markou, A. Tzanikou, E. Ladas, I. Makrigiorgos, G.M. Lianidou, E.

Allele-specific polymerase chain reaction (PCR) (amplification-refractory mutation system, ARMS) is one of the most commonly used methods for mutation detection. However, a main limitation of ARMS-PCR is the false positive results obtained due to non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::a306125f1b68abcfd82b833500957ac1
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3025897

Capillary nonperfusion and photoreceptor loss in branch retinal vein occlusion

Autor: Kanakis, M.G. Giannouli, K. Andreanos, K. Papaconstantinou, D. Koutsandrea, C. Ladas, I. Georgalas, I. Petrou, P. Kotsolis, A.I.

Purpose:To evaluate the photoreceptor layer in eyes with branch retinal vein occlusion associated with macular ischemia, using a method of en face optical coherence tomography (OCT) representation of the ellipsoid zone. Methods:Customized macular OCT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::1beb29e7c02e033fc82c0a729345de4b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3125845

Electroretinographic and optical coherence tomography findings in breast cancer patients using aromatase inhibitors

Autor: Moschos, M.M. Chatziralli, I.P. Sergentanis, T. Zagouri, F. Chrysikos, D. Ladas, I. Zografos, G.

Background: The present cross-sectional study has the purpose to investigate the impact of aromatase inhibitors (AIs) on retinal nerve fiber layer (RNFL) thickness, optic nerve and macular function in patients using AIs for breast cancer treatment. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::1028ded6da075b6efa57fce870ea50bc
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3022510