Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lada Cejkova"'
Autor:
Marketa Chvojkova, David Kolar, Katarina Kovacova, Lada Cejkova, Anna Misiachna, Kristina Hakenova, Lukas Gorecki, Martin Horak, Jan Korabecny, Ondrej Soukup, Karel Vales
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116821- (2024)
Therapeutic options for Alzheimer’s disease are limited. Dual compounds targeting two pathways concurrently may enable enhanced effect. The study focuses on tacrine derivatives inhibiting acetylcholinesterase (AChE) and simultaneously N-methyl-D-as
Externí odkaz:
https://doaj.org/article/ba09458e987a4172bb5b911d5bb2a16e
Autor:
Rafael Dolezal, Kristina Hakenova, Jiri Damborsky, Marharyta Kolcheva, Karel Vales, Jan Korabecny, Lada Cejkova, Marketa Chvojkova, Anna Misiachna, Martin Novák, Ondrej Soukup, Lukas Prchal, Lukas Gorecki, Jana Zdarova Karasova, Martin Horak, Stepan Kortus
Publikováno v:
European journal of medicinal chemistry. 219
Tacrine is a classic drug whose efficacy against neurodegenerative diseases is still shrouded in mystery. It seems that besides its inhibitory effect on cholinesterases, the clinical benefit is co-determined by NMDAR-antagonizing activity. Our previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfc3e0ae05793e4357ad120bae0352e
https://pubmed.ncbi.nlm.nih.gov/33892271
https://pubmed.ncbi.nlm.nih.gov/33892271