Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Lacy M, Simons"'
Autor:
Mark E. Becker, Laura Martin-Sancho, Lacy M. Simons, Michael D. McRaven, Sumit K. Chanda, Judd F. Hultquist, Thomas J. Hope
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate vi
Externí odkaz:
https://doaj.org/article/d1189d67a80f4aab97f5f561dc48a2af
Autor:
Estefany Rios-Guzman, Lacy M. Simons, Taylor J. Dean, Francesca Agnes, Anna Pawlowski, Arghavan Alisoltanidehkordi, Hannah H. Nam, Michael G. Ison, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Respiratory Syncytial Virus (RSV) is a leading cause of acute respiratory tract infection, with the greatest impact on infants, immunocompromised individuals, and older adults. RSV prevalence decreased substantially in the United States (US)
Externí odkaz:
https://doaj.org/article/7ddbb2f971d949b0bf23655c6a925a1c
Autor:
Jenai Quan, Qing Fan, Lacy M. Simons, Samuel N. Smukowski, Caitlin Pegg, Richard Longnecker, Jeffrey N. Savas, Judd F. Hultquist, Gregory A. Smith
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Neurotropic alphaherpesviruses, including herpes simplex virus type 1 and pseudorabies virus, establish a lifelong presence within the peripheral nervous system of their mammalian hosts. Upon entering cells, two conserved tegument proteins,
Externí odkaz:
https://doaj.org/article/c8acdaec5a534af7842134a5fb8c975a
Autor:
Arghavan Alisoltani, Lacy M. Simons, Maria Francesca Reyes Agnes, Taylor A. Heald-Sargent, William J. Muller, Larry K. Kociolek, Judd F. Hultquist, Ramon Lorenzo-Redondo, Egon A. Ozer
Publikováno v:
Virology Journal, Vol 20, Iss 1, Pp 1-12 (2023)
Abstract Background Persistent SARS-CoV-2 infection in immunocompromised hosts is thought to contribute to viral evolution by facilitating long-term natural selection and viral recombination in cases of viral co-infection or superinfection. However,
Externí odkaz:
https://doaj.org/article/4f9b28299fc94ce1b8fc949466b31f88
Autor:
Estefany Rios-Guzman, Alina G. Stancovici, Lacy M. Simons, Grace Barajas, Katia Glenn, Rachel T. Weber, Egon A. Ozer, Ramon Lorenzo-Redondo, Judd F. Hultquist, Maureen K. Bolon
Publikováno v:
Antimicrobial Stewardship & Healthcare Epidemiology, Vol 4 (2024)
Abstract Background: Inpatient behavioral health units (BHUs) had unique challenges in implementing interventions to mitigate coronavirus disease 2019 (COVID-19) transmission, in part due to socialization in BHU settings. The objective of this study
Externí odkaz:
https://doaj.org/article/bcaba3181d294923956d55bfc9c82796
Autor:
Mamadou Saliou Sow, Josue Togo, Lacy M. Simons, Souleymane Taran Diallo, Mohamed Lamine Magassouba, Mamadou Bhoye Keita, Anou Moise Somboro, Youssouf Coulibaly, Egon A. Ozer, Judd F. Hultquist, Robert Leo Murphy, Almoustapha Issiaka Maiga, Mamoudou Maiga, Ramon Lorenzo-Redondo
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/53e515eaa2f7482eac6a3a01ce2d26ee
Autor:
Ryan T. Behrens, Jyothi Krishnaswamy Rajashekar, James W. Bruce, Edward L. Evans, Amelia M. Hansen, Natalia Salazar-Quiroz, Lacy M. Simons, Paul Ahlquist, Judd F. Hultquist, Priti Kumar, Nathan M. Sherer
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT HIV-1 virion production is inefficient in cells derived from mice and other rodents reflecting cell-intrinsic defects to interactions between the HIV-1 auxiliary proteins Tat and Rev and host dependency factors CCNT1 (Cyclin T1) and XPO1 (ex
Externí odkaz:
https://doaj.org/article/e49508a9b94142c094747a11d2fbff48
Autor:
Sadia Samer, Yanique Thomas, Mariluz Araínga, Crystal Carter, Lisa M. Shirreff, Muhammad S. Arif, Juan M. Avita, Ines Frank, Michael D. McRaven, Christopher T. Thuruthiyil, Veli B. Heybeli, Meegan R. Anderson, Benjamin Owen, Arsen Gaisin, Deepanwita Bose, Lacy M. Simons, Judd F. Hultquist, James Arthos, Claudia Cicala, Irini Sereti, Philip J. Santangelo, Ramon Lorenzo-Redondo, Thomas J. Hope, Francois J. Villinger, Elena Martinelli
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2023)
TGF-β plays a critical role in maintaining immune cells in a resting state by inhibiting cell activation and proliferation. Resting HIV-1 target cells represent the main cellular reservoir after long-term antiretroviral therapy (ART). We hypothesize
Externí odkaz:
https://doaj.org/article/d91bfe3dac314d9ab922f0f232b2155b
Autor:
Joseph Hiatt, Judd F. Hultquist, Michael J. McGregor, Mehdi Bouhaddou, Ryan T. Leenay, Lacy M. Simons, Janet M. Young, Paige Haas, Theodore L. Roth, Victoria Tobin, Jason A. Wojcechowskyj, Jonathan M. Woo, Ujjwal Rathore, Devin A. Cavero, Eric Shifrut, Thong T. Nguyen, Kelsey M. Haas, Harmit S. Malik, Jennifer A. Doudna, Andrew P. May, Alexander Marson, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.
Externí odkaz:
https://doaj.org/article/4afe586db1e74b9e9e49556512d17fd5
Autor:
Egon A. Ozer, Lacy M. Simons, Olubusuyi M. Adewumi, Adeola A. Fowotade, Ewean C. Omoruyi, Johnson A. Adeniji, Oluseyi A. Olayinka, Taylor J. Dean, Janet Zayas, Pavan P. Bhimalli, Michelle K. Ash, Almoustapha I. Maiga, Anou M. Somboro, Mamoudou Maiga, Adam Godzik, Jeffrey R. Schneider, João I. Mamede, Babafemi O. Taiwo, Judd F. Hultquist, Ramon Lorenzo-Redondo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
SARS-CoV-2 genomic surveillance has been important for informing pandemic responses but many regions remain under-sampled, limiting knowledge of circulating strains. Here, the authors sequence 378 isolates from Nigeria and identify two strains that a
Externí odkaz:
https://doaj.org/article/60700a3299f04c3ca6c1112d62d4fc0a