Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Lacy Daniels"'
Publikováno v:
Journal of Bacteriology. 198:2020-2028
Phthiocerol dimycocerosates (PDIM) are a group of cell surface-associated apolar lipids of Mycobacterium tuberculosis and closely related mycobacteria, such as Mycobacterium bovis and Mycobacterium leprae . A characteristic methoxy group of these lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71230e2f7e718c6b1ea751b045a3312b
https://doi.org/10.1128/jb.01035-15
https://doi.org/10.1128/jb.01035-15
Publikováno v:
Journal of Biological Chemistry. 285:19135-19144
Glucose 6-phosphate (G6P) is a metabolic intermediate with many possible cellular fates. In mycobacteria, G6P is a substrate for an enzyme, F420-dependent glucose-6-phosphate dehydrogenase (Fgd), found in few bacterial genera. Intracellular G6P level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8998101646650240f3c2cb4e94e035
https://doi.org/10.1074/jbc.m109.074310
https://doi.org/10.1074/jbc.m109.074310
Publikováno v:
Microbiology. 153:2724-2732
Mycobacteria can tolerate relatively high concentrations of triphenylmethane dyes such as malachite green and methyl violet. To identify mycobacterial genes involved in the decolorization of malachite green, a transposon mutant library of Mycobacteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977a0f043a9e1ad2937420cb005039b6
https://doi.org/10.1099/mic.0.2006/009241-0
https://doi.org/10.1099/mic.0.2006/009241-0
Autor:
Clifton E. Barry, Liang Zhang, Thomas Dick, Cynthia S. Dowd, Jason Norton, Lacy Daniels, Helena I. Boshoff, Siew Siew Pang, Thomas J. Albert, Ujjini H. Manjunatha
Publikováno v:
Proceedings of the National Academy of Sciences. 103:431-436
PA-824 is a promising new compound for the treatment of tuberculosis that is currently undergoing human trials. Like its progenitors metronidazole and CGI-17341, PA-824 is a prodrug of the nitroimidazole class, requiring bioreductive activation of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b7a764298d83c9af2f2136e57e4365
https://doi.org/10.1073/pnas.0508392103
https://doi.org/10.1073/pnas.0508392103
Autor:
Lacy Daniels
Publikováno v:
Journal of Life Science. 15:182-185
IS1096 transposon을 사용하여 결핵균군에 작용하는 항생제인 PA-824에 내성을 나타내는 Mycobacterium bovis BCG의 돌연변이 균주를 얻고자 하였고, 그 결과 24 종류의 서로 다른 돌연변이 균주를 얻을
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fed30fb55ee462149cb8889a01f1d9f8
https://doi.org/10.5352/jls.2005.15.2.182
https://doi.org/10.5352/jls.2005.15.2.182
Publikováno v:
Protein Expression and Purification. 35:171-180
The sequence of the gene from Nocardia sp. NRRL 5646 encoding GTP cyclohydrolase I (GCH), gch, and its adjacent regions was determined. The open reading frame of Nocardia gch contains 684 nucleotides, and the deduced amino acid sequence represents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0530bd83fb37d062e8dc56a0098e37
https://doi.org/10.1016/j.pep.2004.02.008
https://doi.org/10.1016/j.pep.2004.02.008
Publikováno v:
Applied and Environmental Microbiology. 70:1874-1881
We have cloned, sequenced, and expressed the gene for a unique ATP- and NADPH-dependent carboxylic acid reductase (CAR) from a Nocardia species that reduces carboxylic acids to their corresponding aldehydes. Recombinant CAR containing an N-terminal h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51a50e3a5596b117b47766b6b4fee59
https://doi.org/10.1128/aem.70.3.1874-1881.2004
https://doi.org/10.1128/aem.70.3.1874-1881.2004
Publikováno v:
Journal of Bacteriology. 184:2420-2428
Using the nitroimidazopyran-based antituberculosis drug PA-824 as a selective agent, transposon-generated Mycobacterium bovis strain BCG ( M. bovis ) mutants that could not make coenzyme F 420 were identified. Four independent mutants that could not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dce4da9a38691efb1743553cc95ee4
https://doi.org/10.1128/jb.184.9.2420-2428.2002
https://doi.org/10.1128/jb.184.9.2420-2428.2002
Publikováno v:
Journal of Bacteriology. 183:7058-7066
Three transposon Tn 5367 mutagenesis vectors (phAE94, pPR28, and pPR29) were used to create a collection of insertion mutants of Mycobacterium bovis strain BCG. A strategy to select for transposon-generated mutants that cannot make coenzyme F 420 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06100a9d5595ff7693b2db99c3a6b9ad
https://doi.org/10.1128/jb.183.24.7058-7066.2001
https://doi.org/10.1128/jb.183.24.7058-7066.2001