Time-dependent biochemical effects of the promising anticancer drug 3-bromopyruvate and its biochemical analogs pyruvate and lactate (Warburg effect) on C6 glioma-induced H2O2 production

Autor: Salah Mohamed El Sayed

Publikováno v: SVU - International Journal of Medical Sciences, Vol 7, Iss 2, Pp 223-231 (2024)

Background: Pyruvate (an antioxidant) result from aerobic glucose oxidation (aerobic glycolysis) while lactate (a pro-oxidant metabolite in the tumor microenvironment) results from anaerobic glycolysis. Lactate is a structural analog to pyruvate (for

Externí odkaz: https://doaj.org/article/6d7963415c3e415aa4767422862bf20a

Sexual dimorphic effects of igf1 deficiency on metabolism in zebrafish

Autor: Ningmei Zeng, Jiankang Bao, TingTing Shu, Chuang Shi, Gang Zhai, Xia Jin, Jiangyan He, Qiyong Lou, Zhan Yin

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Insulin-like growth factor 1 (IGF1) is an essential effector of the growth hormone (GH)/IGF1 axis for somatic growth regulation in mammals. However, its functions have not been thoroughly investigated in zebrafish in vivo. In this study, the igf1-def

Externí odkaz: https://doaj.org/article/7b574afff5a5480298c9199a49cdf417

The investigation of the influence which is done as a result of macleaya cordata and biologically active additives on the carbohydrate metabolism in pigs

Autor: I. O. Zhukova, A. A. Molchanov, I. O. Kostiuk, O. M. Bobrytska, N. I. Lonhus, I. A. Ionov

Publikováno v: Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, Vol 21, Iss 93, Pp 137-142 (2019)

Pork production plays a significant role in meat balance of Ukraine. High productivity of pigs is accompanied with increased intensity of metabolic processes and intense functional activity of all organs and systems, which requires additional support

Externí odkaz: https://doaj.org/article/9ffa42593d034234b1c764818374d2e3

PRE-PERFUSION LACTATE LEVEL AND LACTATE-PYRUVATE RATIO AS A PROGNOSTIC CRITERION OF DEVELOPMENT OF POST-PERFUSION CARDIAC FAILURE DURING THE MYOCARDIAL REVASCULIZATION SURGERY WITH THE USE OF CARDIOPULMONARY BYPASS

Autor: Yu. S. Polushin, N. S. Molchan, A. A. Zhloba, M. Yu. Shiganov, A. E. Kobak, A. A. Khryapa

Publikováno v: Вестник анестезиологии и реаниматологии, Vol 13, Iss 4, Pp 19-28 (2018)

Goal of the study: to detect the correlation between lactate and pyruvate levels and their ratio (LPR) during ischemia/reperfusion with the post-operative increase of troponin I as a marker of myocardial lesion. Materials and methods. The study was p

Externí odkaz: https://doaj.org/article/26a5195687f74f6288d7edf7355f8dd9

IMPACT OF PYRUVATE CONCENTRATION IN BLOOD ON THE DEVELOPMENT OF POST-PERFUSION CARDIAC FAILURE IN MYOCARDIAL REVASCULIZATION SURGERY WITH CARDIOPULMONARY BYPASS

Autor: N. S. Molchan, A. A. Zhloba, Yu. S. Polushin, M. Yu. Shiganov, A. E. Kobak, A. A. Khryapa, I. V. Tretyakova

Publikováno v: Вестник анестезиологии и реаниматологии, Vol 13, Iss 6, Pp 23-30 (2018)

Goal of the study: to evaluate the capability of pyruvate which is endogenously produced during myocardium anoxia to prevent the post-perfusion cardiac failure in the patients undergoing revasculization surgery with cardiopulmonary bypass. Materials

Externí odkaz: https://doaj.org/article/792ab9788a924251b82d29511bb7b7f0