Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function.

Autor: Wanes D; Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany., Stellbrinck T; Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany., Marten LM; Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Göttingen, Germany., Santer R; Department of Pediatrics, University Medical Center Eppendorf, Hamburg, Germany., Naim HY; Department of Biochemistry, University of Veterinary Medicine Hannover, Hannover, Germany Hassan.Naim@tiho-hannover.de.

Publikováno v: Gut [Gut] 2024 Sep 09; Vol. 73 (10), pp. e16. Date of Electronic Publication: 2024 Sep 09.

Comparison of the developmental effects of lactase or bisphenol A antibody immobilized polycaprolactone/silk fibroin nanofibers on zebrafish embryos.

Autor: Sivas GG; Department of Biochemistry, Institute of Health Sciences, Marmara University, Istanbul, Turkey., Ünal İ; Department of Biochemistry, Institute of Health Sciences, Marmara University, Istanbul, Turkey., Gürel-Gökmen B; Department of Biochemistry, Institute of Health Sciences, Marmara University, Istanbul, Turkey., Emekli-Alturfan E; Department of Basic Medical Sciences, Faculty of Dentistry, Marmara University, Istanbul, Turkey., Tunalı Akbay T; Department of Basic Medical Sciences, Faculty of Dentistry, Marmara University, Istanbul, Turkey. Electronic address: ttunali@marmara.edu.tr.

Publikováno v: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Sep; Vol. 191, pp. 114871. Date of Electronic Publication: 2024 Jul 17.

Added Value of ¹³ C Analysis in Breath Tests in H 2 -Negative Subjects to Diagnose Lactose Malabsorption: A Proof of Concept Study.

Autor: Balsiger LM; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. lukasmichaja.balsiger@kuleuven.be., Houben E; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.; Department of Laboratory Medicine Cosis, University Hospitals Leuven, Leuven, Belgium., Vanuytsel T; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium., van Ranst M; Department of Laboratory Medicine Cosis, University Hospitals Leuven, Leuven, Belgium.; Laboratory of Clinical and Epidemiological Virology (Rega Institute), Leuven, Belgium., Tack J; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium., Verbeke K; Translational Research Center for Gastrointestinal Disorders, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Publikováno v: Digestive diseases and sciences [Dig Dis Sci] 2024 Jun; Vol. 69 (6), pp. 2147-2153. Date of Electronic Publication: 2024 Mar 18.

Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.

Autor: Han S; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Yao J; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Yamazaki H; Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8303, Japan.; Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University, Fukushima 960-1295, Japan., Streicher SA; Cancer Epidemiology Division, Population Sciences in the Pacific Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI 96813, USA., Rao J; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Nianogo RA; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Zhang Z; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Huang BZ; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

Publikováno v: Nutrients [Nutrients] 2024 Mar 12; Vol. 16 (6). Date of Electronic Publication: 2024 Mar 12.

Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes.

Autor: Luo K; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Chen GC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Nutrition and Food Hygiene, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China., Zhang Y; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Moon JY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Xing J; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Peters BA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Usyk M; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Wang Z; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Hu G; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Li J; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Rebholz CM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wang T; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Yu B; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Knight R; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Burk RD; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. qibin.qi@einsteinmed.edu.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. qibin.qi@einsteinmed.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 Jan; Vol. 6 (1), pp. 169-186. Date of Electronic Publication: 2024 Jan 22.