A central chaperone-like role for 14-3-3 proteins in human cells

Autor: Segal, Dmitri, Maier, Stefan, Mastromarco, Giovanni J., Qian, Wesley Wei, Nabeel-Shah, Syed, Lee, Hyunmin, Moore, Gaelen, Lacoste, Jessica, Larsen, Brett, Lin, Zhen-Yuan, Selvabaskaran, Abeeshan, Liu, Karen, Smibert, Craig, Zhang, Zhaolei, Greenblatt, Jack, Peng, Jian, Lee, Hyun O., Gingras, Anne-Claude, Taipale, Mikko

Publikováno v: In Molecular Cell 16 March 2023 83(6):974-993

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Pervasive mislocalization of pathogenic coding variants underlying human disorders.

Autor: Lacoste J; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada.; These authors contributed equally., Haghighi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; These authors contributed equally., Haider S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada., Segal D; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Reno C; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Qian WW; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Xiong X; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada., Shafqat-Abbasi H; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ryder PV; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Senft R; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cimini BA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Roth FP; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada., Calderwood M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Hill D; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Vidal M; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Yi SS; Livestrong Cancer Institutes, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.; Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX, USA.; Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, USA.; Interdisciplinary Life Sciences Graduate Programs (ILSGP), College of Natural Sciences, The University of Texas at Austin, Austin, TX, USA., Sahni N; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX, USA., Peng J; Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Gingras AC; Department of Molecular Genetics, University of Toronto, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada., Singh S; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Carpenter AE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Taipale M; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Canada.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 05. Date of Electronic Publication: 2023 Sep 05.