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Akademický článek

Synthesis and Preclinical Characterization of LY3154885, a Human Dopamine D1 Receptor Positive Allosteric Modulator with an Improved Nonclinical Drug-Drug Interaction Risk Profile.

Autor: Hao J, Beck J, Zhou X, Lackner GL, Johnston R, Reinhard M, Goldsmith P, Hollinshead S, Dehlinger V, Filla SA, Wang XS, Richardson J, Posada M, Mohutsky M, Schober D, Katner JS, Chen Q, Hu B, Remick DM, Coates DA, Mathes BM, Hawk MK, Svensson KA, Hembre E

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Mar 10; Vol. 65 (5), pp. 3786-3797. Date of Electronic Publication: 2022 Feb 17.

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Akademický článek

General Access to Concave-Substituted cis -Dioxabicyclo[3.3.0]octanones: Enantioselective Total Syntheses of Macfarlandin C and Dendrillolide A.

Autor: Allred TK; Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States., Dieskau AP; Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States., Zhao P; Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States., Lackner GL; Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States., Overman LE; Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2020 Dec 04; Vol. 85 (23), pp. 15532-15551. Date of Electronic Publication: 2020 Nov 16.

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Akademický článek

Enantioselective Total Synthesis of Macfarlandin C, a Spongian Diterpenoid Harboring a Concave-Substituted cis-Dioxabicyclo[3.3.0]octanone Fragment.

Autor: Allred TK; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA., Dieskau AP; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA., Zhao P; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA., Lackner GL; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA., Overman LE; Department of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, CA, 92697-2025, USA.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Apr 06; Vol. 59 (15), pp. 6268-6272. Date of Electronic Publication: 2020 Feb 19.

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Akademický článek

Short Enantioselective Total Syntheses of trans-Clerodane Diterpenoids: Convergent Fragment Coupling Using a trans-Decalin Tertiary Radical Generated from a Tertiary Alcohol Precursor.

Autor: Slutskyy Y; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Jamison CR; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Lackner GL; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Müller DS; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Dieskau AP; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Untiedt NL; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Overman LE; Department of Chemistry, University of California , 1102 Natural Sciences II, Irvine, California 92697-2025, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2016 Aug 19; Vol. 81 (16), pp. 7029-35. Date of Electronic Publication: 2016 Jun 02.

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Akademický článek

Constructing Quaternary Carbons from N-(Acyloxy)phthalimide Precursors of Tertiary Radicals Using Visible-Light Photocatalysis.

Autor: Pratsch G; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, United States., Lackner GL; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, United States., Overman LE; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2015 Jun 19; Vol. 80 (12), pp. 6025-36. Date of Electronic Publication: 2015 Jun 01.

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Akademický článek

Fragment Coupling and the Construction of Quaternary Carbons Using Tertiary Radicals Generated From tert-Alkyl N-Phthalimidoyl Oxalates By Visible-Light Photocatalysis.

Autor: Lackner GL; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025., Quasdorf KW; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025., Pratsch G; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025., Overman LE; Department of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2015 Jun 19; Vol. 80 (12), pp. 6012-24. Date of Electronic Publication: 2015 Jun 01.

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Correction to "constructing quaternary stereogenic centers using tertiary organocuprates and tertiary radicals. total synthesis of trans-clerodane natural products".

Autor: Müller DS, Untiedt NL, Dieskau AP, Lackner GL, Overman LE

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2015 Apr 15; Vol. 137 (14), pp. 4874. Date of Electronic Publication: 2015 Apr 02.

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Akademický článek

Constructing quaternary stereogenic centers using tertiary organocuprates and tertiary radicals. Total synthesis of trans-clerodane natural products.

Autor: Müller DS; Department of Chemistry, University of California, Irvine , 1102 Natural Sciences II, Irvine, California 92697-2025, United States., Untiedt NL, Dieskau AP, Lackner GL, Overman LE

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2015 Jan 21; Vol. 137 (2), pp. 660-3. Date of Electronic Publication: 2015 Jan 13.

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Akademický článek

Direct construction of quaternary carbons from tertiary alcohols via photoredox-catalyzed fragmentation of tert-alkyl N-phthalimidoyl oxalates.

Autor: Lackner GL; Department of Chemistry, University of California , Irvine, California 92697-2025, United States., Quasdorf KW, Overman LE

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2013 Oct 16; Vol. 135 (41), pp. 15342-5. Date of Electronic Publication: 2013 Oct 02.

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