VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation

Autor: Kayvanpour, Elham, Wisdom, Michael, Lackner, Maximilian K., Sedaghat-Hamedani, Farbod, Boeckel, Jes-Niels, Müller, Marion, Eghbalian, Rose, Dudek, Jan, Doroudgar, Shirin, Maack, Christoph, Frey, Norbert, Meder, Benjamin

Mutations in mitochondrial aminoacyl-tRNA synthetases (mtARSs) have been reported in patients with mitochondriopathies: most commonly encephalopathy, but also cardiomyopathy. Through a GWAS, we showed possible associations between mitochondrial valyl

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VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation.

Autor: Kayvanpour E; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 10785 Berlin, Germany., Wisdom M; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 10785 Berlin, Germany., Lackner MK; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany., Sedaghat-Hamedani F; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 10785 Berlin, Germany., Boeckel JN; Clinic and Polyclinic for Cardiology, University of Leipzig, 04109 Leipzig, Germany., Müller M; Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, University Hospital of the Ruhr-Universität Bochum, 32545 Bad Oeynhausen, Germany., Eghbalian R; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 10785 Berlin, Germany., Dudek J; Comprehensive Heart Failure Center (CHFC), University Hospital, Julius-Maximilians University of Würzburg, 97070 Würzburg, Germany., Doroudgar S; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona-College of Medicine Phoenix, Phoenix, AZ 85004, USA., Maack C; Comprehensive Heart Failure Center (CHFC), University Hospital, Julius-Maximilians University of Würzburg, 97070 Würzburg, Germany., Frey N; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 10785 Berlin, Germany., Meder B; Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, 69120 Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, 10785 Berlin, Germany.; Klaus Tschira Institute for Computational Cardiology, 69120 Heidelberg, Germany.; Department of Medicine III, University of Heidelberg, INF 410, 69120 Heidelberg, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Jun 30; Vol. 23 (13). Date of Electronic Publication: 2022 Jun 30.