Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Lachlan Robert Gray"'
Autor:
Damian F. J. Purcell, Sharon R Lewin, Samantha Adikari, Wan-Jung Cheng, Michael A Moso, Anne Ellett, Georges Khoury, Lachlan Robert Gray, Judy Chang, John Zaunders, Jenny L. Anderson, Melissa J Churchill, Jonathan C. Jacobson, Paul U. Cameron, Suha Saleh, Hao K. Lu
Publikováno v:
AIDS. 33:199-209
OBJECTIVE To determine whether latency can be established and reversed in both proliferating and nonproliferating CD4+ T cells in the same model in vitro. METHODS Activated CD4+ T cells were infected with either a nonreplication competent, luciferase
Autor:
Marilyn Lewis, Mike Westby, Jacqueline K. Flynn, Jingling Zhou, Paula Clarisa Ellenberg, Sharon R Lewin, Melissa J Churchill, Anne Ellett, Kieran Cashin, Katharina Borm, Michael Roche, Becky Jubb, Renee C. Duncan, Lachlan Robert Gray, Jasminka Sterjovski, Paul R Gorry, Benhur Lee
Publikováno v:
AIDS Research and Human Retroviruses. 33:1220-1235
Maraviroc (MVC) is an allosteric inhibitor of human immunodeficiency virus type 1 (HIV-1) entry, and is the only CCR5 antagonist licensed for use as an anti-HIV-1 therapeutic. It acts by altering the conformation of the CCR5 extracellular loops, rend
Autor:
Ting Ting Lee, Anne Ellett, Ian P. Everall, Melissa J Churchill, Lachlan Robert Gray, Paul R Gorry, Gursharan Chana, Chad A. Bousman
Publikováno v:
Journal of NeuroVirology. 21:535-543
This investigation aimed to assess whether inhibition of cathecol-O-methyl transferase (COMT) by tolcapone could provide neuroprotection against HIV-associated neurodegenerative effects. This study was conducted based on a previous work, which showed
Autor:
Lucette A. Cysique, David M. Margolis, Melissa J Churchill, J V Garcia, Kevin Robertson, Edwina J. Wright, Joseph L. Mankowski, Brian Spencer, Jeymohan Joseph, Bruce J. Brew, Suzanne M. Crowe, Benjamin B. Gelman, Lachlan Robert Gray, Tory P. Johnson, Steven G. Deeks
Publikováno v:
Journal of Neurovirology
On 18 July 2014, the National Institute of Mental Health in collaboration with ViiV Health Care and Boehringer Ingelheim supported a symposium on HIV eradication and what it meant for the brain. The symposium was an affiliated event to the 20th Inter
Autor:
Lachlan Robert Gray, Jacqueline K. Flynn, Paul R Gorry, Melissa J Churchill, Steven Lodewyk Wesselingh, Michael Roche
Publikováno v:
Current Opinion in HIV and AIDS. 9:552-558
Purpose of review: To summarize the evidence in the literature that supports the central nervous system (CNS) as a viral reservoir for HIV-1 and to prioritize future research efforts. Recent findings: HIV-1 DNA has been detected in brain tissue of pa
Autor:
Steven Lodewyk Wesselingh, Lachlan Robert Gray, Melissa J Churchill, Casey Welsh, Emma Crespan, Paul R Gorry, Daniel Cowley, Charlene Mackenzie
Publikováno v:
AIDS Research and Human Retroviruses. 29:365-370
New evidence indicates that astrocytes of the central nervous system (CNS) are extensively infected with human immunodeficiency virus type 1 (HIV-1) in vivo. Although no new virus is produced, this nonproductive or restricted infection contributes to
Publikováno v:
Expert Opinion on Biological Therapy. 13:403-409
Introduction: There is increasing interest in the possibility of eradication of HIV, given the recent case reports. However, it is not clear to what extent brain involvement by HIV poses a challenge to systemic eradication strategies. Areas covered:
Autor:
Y. Li, Lachlan Robert Gray, Melissa J Churchill, Khamis Tomusange, Danushka K. Wijesundara, Eric J. Gowans, Branka Grubor-Bauk, Tamsin J. Garrod, Jason Gummow
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss, Pp 25-(2016)
Autor:
Danushka K. Wijesundara, Branka Grubor-Bauk, Khamis Tomusange, Eric J. Gowans, Jason Gummow, Tamsin J. Garrod, Yanrui Li, Lachlan Robert Gray, Melissa J Churchill
Publikováno v:
Scientific Reports
DNA vaccines are cost-effective to manufacture on a global scale and Tat-based DNA vaccines have yielded protective outcomes in preclinical and clinical models of human immunodeficiency virus (HIV), highlighting the potential of such vaccines. Howeve
Autor:
Paul A. Ramsland, Anne Ellett, Melissa J Churchill, Jasminka Sterjovski, Anthony L. Cunningham, Paul R Gorry, Michael Roche, Kieran Cashin, Lachlan Robert Gray
Publikováno v:
Journal of Virology. 85:10699-10709
Macrophage tropism of human immunodeficiency virus type 1 (HIV-1) is distinct from coreceptor specificity of the viral envelope glycoproteins (Env), but the virus-cell interactions that contribute to efficient HIV-1 entry into macrophages, particular